Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 378 for “"cell signaling"”.
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Regulation of T-cell signaling networks
… of how biology carries information within cells, it is not sufficient to look at individual protein or gene interactions, but to understand these networks of interactions as a whole. The goal of this thesis is to understand various aspects of how cells in general and T-cells in particular …
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Stochastic processes in T-cell signaling
T cells are orchestrators for adaptive immunity. Antigen recognition by T cells is mediated by the interactions between T-cell receptors (TCRs) and peptide-MHC (pMHC) molecules. How T cells can translate stimulatory external cues (e.g., TCRpMHC interactions where the peptides are derived from …
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Tools to analyse cell signaling models
… qualitative and quantitative characteristics of cell-signaling models. The qualitative behavior of deterministic models is studied in the first part of this thesis and the quantitative behavior of stochastic models is studied in the second part. A kinetic model of cell signaling is a common …
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Cell Signaling Components of the Drosophila Circadian Pacemaker
… and are required in a specific set of pacemaker cells in the Drosophila brain for locomotor rhythms. These cells are divided into distinct subgroups and evidence suggests that subgroups of pacemaker cells may control distinct components of circadian behavior although these assignments are not …
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Molecular Mechanisms Of Pressure-Stimulated Cancer Cell Signaling
… MECHANISMS OF PRESSURE-STIMULATED CANCER CELL SIGNALING</p> <p>by</p> <p>CHRISTINA DOWNEY</p> <p>June 2010</p> <p>Advisor: Dr. Marc Basson, MD, PhD</p> <p>Major: Cancer Biology</p> <p>Degree: Doctor of Philosophy</p> <p> Increased extracellular pressure stimulates cancer cell adhesion by a …
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Host cell signaling in response to RSV infection
… mechanisms and consequences of RSV-induced host cell signaling. My dissertation project provides three major contributions to this field.\r\nFirstly, I found that retinoic acid-inducible gene I (RIG-I) and Toll like receptor 3 (TLR3) play distinct roles in mediating RSV-induced innate immune …
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Enzyme microspheres for biosensing and cell signaling perturbation
… a more precise control over site-specific cellular manipulation by delivering a particle, decorated with optimal amount of effectors, into specific location of a living cell using optical trapping. In our approach, alkaline phosphatase (ALP) was used as an effector to generate product …
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Mathematical Modeling and Computational Studies for Cell Signaling
… mammals play a pivotal role in many aspects of cellular functions. The mating decision in yeast is a switch-like or bistability response that allows cells to filter out weak pheromone signals or avoiding improper mating when a mate is sufficiently close. In many cases, scaffold proteins are …
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Mechanically-Induced Osteocyte-Th17-Cell Signaling and Osteoclastogenesis
… of bone resorbing osteoclasts. However, the extracellular signals involved in the initiation of targeted bone remodeling are still unknown. While apoptosis is commonly referred to as a non-inflammatory event, inflammatory cytokines have been shown to be mediators of the bone remodeling process. To …
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Relating topology and dynamics in cell signaling networks
Cells are constantly bombarded with stimuli that they must sense, process, and interpret to make decisions. This capability is provided by interconnected signaling pathways. Many of the components and interactions within pathways have been identified, and it is becoming clear that the precise …
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Stochastic and spatiotemporal effects in T-cell signaling
… and the physical sciences to understand how T cells balance the risks of autoimmunity and infection. (1) What features of proteins do T cells search for that correlate with pathogenicity, distinguishing self from foreign? Two contrasting theories have emerged that attempt to describe T cell …
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Protein-Protein Interactions and Muscle cell Signaling Via Syntrophin
… oligomerization and its interactions with the cell signaling components <em>in vitro</em> in skeletal muscle were investigated.</p> <p>Mouse a1-syntrophin sequences, produced as chimeric fusion proteins in bacteria, als o oligomerize and in a micromolar Ca<sup>2+</sup>-dependent manner. …
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O-GlcNAc-Mediated Protein-Protein Interactions in Cell Signaling
… β-N-acetylglucosamine (O-GlcNAc) is an essential signaling mechanism that affects diverse processes such as cell cycle, metabolism, and death. Aberrant signaling has been implicated in numerous human diseases including cancer and neurodegeneration. However, major aspects of O-GlcNAc signaling are …
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Engineered hydrogels for tracking cell signaling from the outside-in
… therapies involves the conversion of somatic cells back into an embryonic stem cell (ES)-like state, termed induced pluripotent stem cells (iPS). iPS cells have the same potential for differentiation as ES cells and hold immense promise for tissue engineering, regenerative medicine, and …
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Quantitative studies of EGFR autocrine induced cell signaling and migration
… factor (EGF) receptor autocrine and/or paracrine signaling plays an important role in normal epithelial cell proliferation, survival, adhesion and migration. Aberrant expression of the EGF receptor and its cognate ligands have been implicated in various types of cancers, hence EGF receptor …
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The roles of clustered membrane proteins in T-cell signaling
… that can respond to diverse pathogens. Mature T cells, one of the most important immune cells generated from the thymus through a rigorous selection processes, are key orchestrators of the immune responses. Although many of the key signaling molecules in T cells have been discovered, the …
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The Role of Piezo1 in Mediating Chondrocyte Cell Signaling and Senescence
… been implicated in OA progression via calcium signaling in chondrocytes. This study investigates the role of conditional Piezo channel knockout (cKO) in modulating calcium signaling and senescence in OA, particularly under the supra-physiologic inflammatory condition of a high-fat diet (HFD). …
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Immunocytochemistry, Mass Spectrometry and Microengineering for the Study of Cell Signaling
… of physiological and behavioral aspects of cell signaling mediated by neuropeptide transmitters in the brain of Aplysia californica . This combination of techniques provides complementary qualitative information on the peptide structural identity, localization and action within a particular …
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Discovering angiogenic cell signaling landscapes: Quantitative mapping through experiment and computation
… control, because angiogenesis involves other signaling axes, such as the PDGFs. In cancer, for example, anti- angiogenic therapeutics primarily target the VEGF signaling family, but their success is limited by the development of drug resistance. These challenges in VEGF targeting, and recent …
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