Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"cell signal"”.
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Bayesian causal inference of cell signal transduction from proteomics experiments
<p>Cell signal transduction describes how a cell senses and processes signals from the environment using networks of interacting proteins. In computational systems biology, investigators apply machine learning methods for causal inference to develop causal Bayesian network models of signal …
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Development of the in vivo flow cytometer
… detection and quantification of circulating cells containing fluorescent proteins or labeled with fluorochrome molecules in live animals, without the need to extract blood samples. A stationary laser beam is focused by a cylindrical lens to a slit of light that is then demagnified and focused …
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The Role of Dna Methylation and Hydroxymethylation In Smooth Muscle Cell Phenotypic Change During Atherogenesis
… atherogenesis, lipid deposits, inflammation, and cells accumulate within the walls of arteries, ultimately leading to a buildup of fatty plaques and occlusion of the arterial lumen. In a multifactorial disease like atherosclerosis there are complex interplays between environmental, genetic and …
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Physiological and cellular characterization of a plant natriuretic peptide
… capacity to survive. Plants can use multiple signaling pathways and signals to mediate their response; for example, at least four different signal pathways have been identified for water-deficit stress (Shinozaki and Yamaguchi-Shinozaki, 1997; Xiong et al., 2002). Different forms of stress may …
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The surface electromyography-force relationship during isometric dorsiflexion in males and females
… the action of the dorsiflexors. The surface EMG signal was amplified (lOOOx), band-pass filtered (10-500Hz), and sampled at 2048 Hz. The load cell signal was low-passed filtered at 100 Hz and sampled at the same rate. Males were stronger than females {P <0.05). However, there was no significant …
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High speed internet access using cellular infrastructure
… such as WiFi, WiMAX, MBWA, satellite and cell phone networks. This thesis examines the potential usage of providing Internet access through cellular infrastructure. The cellular evolution path from first generation (1G) to third generation (3G) and fourth generation (4G) systems is studied …
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Disulfide Bridging the Gap between Src and Cortactin: A New Paradigm in SH2 Domain-mediated Signaling
… tyrosine kinase that also regulates normal cell homeostasis through phosphorylation of multiple downstream substrates. Cortactin is an actin binding protein and nucleation promoting factor that promotes the formation of stable branching networks within the actin cytoskeleton. Together, these …
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Nuclear magnetic resonance microscopy and diffusion
… neuron physiology and activation in vivo at near cellular resolution. Using biocompatible crosslinked Hemoglobin (xHb) as a contrast agent, we demonstrated partial local oxygen pressure (pO₂) monitoring in vivo with a home-built high resolution microscopy imaging probe. It is one of the most …
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Modularity of signaling cycle architectures
… Phosphorylation cycles are ubiquitous in cell signal-transduction systems. Single phosphorylation cycles have been found to have insulating properties that reduce the effect of downstream loads. The analysis of these cycles is thus important in understanding their role in signaling systems …
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Localization and Function of Bacterial Type III and IV Effector Proteins
Eukaryotic cell signal transduction networks are highly dynamic and complex systems largely composed of signaling enzymes with modular protein interaction domains and subcellular localization motifs. These sophisticated regulatory mechanisms are crucial to the fidelity and efficacy of information …
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Analysis and Interpretation of Complex Biological Signal Transduction Networks
Cellular signaling is a complex system of biological communication that coordinates cellular activities via biochemical reactions. The passing of an extracellular signal across a cell membrane to intracellular signaling molecules is referred to as signal transduction. Signals transduced across a …
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Actin Regulatory Dynamics Required for T Cell Activation: A Quantitative and Systems-Level Perspective
T cell activation occurs through interaction with an antigen-presenting cell (APC). Upon activation, signaling ensues with the coordination of dozens of diverse signaling molecules in space and time, a feature of cell signaling we call ‘spatiotemporal patterning’. We performed a systems-scale …
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Optimizing Multi-Well Micro-Electrode Array (MW-MEA) Design to Study the Electrophysiology of Neurons
… improve the recording efficiency from a group of cells in an area to have a better understanding of what is happening over a larger network. This study included three phases: investigating the effectiveness of a preliminary version of multi-well MEA design with two electrode types featuring a …
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Cellular and Molecular Aspects Of Naïve T cell Priming for Adoptive Immunotherapy
… in the advancement of immunotherapy. Adoptive cell therapy (ACT) is a modality that aims to generate a robust tumour-directed response by the infusion of tumour specific, ex vivo expanded, autologous cells. In this thesis we examine aspects of naïve T cell culture with the aim of improving …
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TLR4 endogenous ligand S100A8/A9 levels in adult-onset Still’s disease and their association with disease activity and clinical manifestations
… Peripheral blood mononuclear cells (PBMC) from active AOSD and HC were evaluated for IL-1β release, and in vitro study with PBMC and THP-1 cell line was done for cell signal of S100A8/A9. Results: Serum S100A8/A9 in AOSD patients was higher than those of RA patients and HC. …
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Effect of Anti-fibrotic Drug (Pirfenidone) on TGF-β Signaling Pathway in Ocular Fibrotic Disorders
… in transforming retinal pigment epithelial (RPE) cells into mesenchymal fibroblastic cells, which are implicated in fibrotic disorders of the retina. Herein, the effect of pirfenidone, a novel anti-fibrotic agent, on TGF-β1-mediated fibrogenesis in the human RPE cell line (ARPE)-19 was tested. …
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Modulation of CD8+ T Cell Function by Beta2-Adrenergic Receptor Signaling
… upon stimulation, which can modulate immune cell function primarily through the beta2-adrenergic receptor (ADRB2). Our previous work has demonstrated that various subsets of CD8+ T cells have differential expression of the ADRB2 transcript. The role of ADRB2 signaling on the differentiation …
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Sympathetic Neural Control of Inflammation by ADRB2-Mediated IL-10 Secretion
… nervous system to communicate with immune cells through adrenergic receptors (ADR). Although, the effects of adrenergic signaling has been studied in multiple cell types, its role in modulation of innate immune cells is relatively unknown. Here, I demonstrate a novel role for the beta2-ADR …