Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"cell senescence"”.
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Cell senescence and aging in carcinogenesis and liver repopulation
… We took advantage of a model of orthotopic cell transplantation to explore the basic question as to whether the contribution of aging to the risk of cancer is, at least in part, related to alterations in the tissue microenvironment. Previous investigations conducted by our research group had …
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THE IMPACT OF VASCULAR SMOOTH MUSCLE CELL SENESCENCE ON MITOCHONDRIA DYSFUNCTION AND ANGIOGENESIS
… all’età, caratterizzata dall’accumulo di cellule senescenti, in particolare di cellule muscolari lisce vascolari (VSMC). Queste cellule, pur mantenendo un’attività metabolica, mostrano importanti alterazioni morfologiche, disfunzioni mitocondriali e adottano un fenotipo secretorio …
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Mechanisms of cell senescence: p21 and DNA damage response in aging and longevity
… cyclin-dependent kinase inhibitor which triggers cell growth arrest associated with senescence and damage response and notably is involved in the up-regulation of multiple genes that have been associated with senescence or implicated in age-related . This PhD thesis project that has been performed …
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Effects of Stress Coping Mechanisms on Telomere length: A literature review.
… to exposure to stressors but strongly related to cell life cycle and cell senescence. Cell level stressors are related to reductions in telomere length as well as some social stressors showing moderate associations with telomere length. However, very little data has been produced in the arena of …
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A novel high-throughput in-cell Western assay for the quantitative measurement of signaling dynamics in DNA damage signaling networks : cell decision processes in response to DNA double strand breaks
Following exposure to DNA damage, cells initiate a stress response involving multiple protein kinase signaling cascades. The DNA damage response results in one of several possible cell-fate decisions, or cellular responses: induction of cell-cycle arrest, initiation of DNA repair, activation of …
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Functional role of GSK3β in p38MAPK mediated human amnion membrane senescence
… kinase (p38MAPK) activation and fetal membrane senescence are associated with parturition. Our study determined changes in multipotent pro-cell cycle regulator glycogen synthase kinase (GSK) 3β and its regulation by p38MAPK in effecting senescence to further delineate the molecular mechanism …
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Mechano-sensitivity of nuclear lamin proteins in endothelial cells
… Hutchinson Gilford Progeria Syndrome (HGPS) cells and aging cells, implicating dysfunctions of lamin A/C in aging process and atherosclerosis, as HGPS is caused by a mutated form of lamin A/C. Blood flow in arteries is generating shear stress that is mostly applied on endothelial cells that …
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Regulation mechanisms of Drosophila retinoblastoma protein stability and repression activity
… transcriptional corepressors involved in diverse cellular events. As a potent tumor suppressor, RB plays a variety of important roles including regulating cell cycle, promoting cellular differentiation, inducing cell senescence and balancing apoptotic death, many of which are controlled by …
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Enhancement of Carotenoid Biosynthesis and Antioxidant Responses in Diatoms by Light Modulation
… together with antioxidant molecules during cell senescence. More generally, the physiological state of the cells modulates the antioxidant and photoprotective network in diatoms.
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Mechanisms of microenvironmental paracrine signaling in cancer chemoresistance
… the context of a tissue environment, with cancer cells surrounded by many non-malignant cells that contribute to tumor growth and resistance to therapy. Yet much remains unknown about the tumor microenvironment and its impact on therapeutic response. The specific cell types and microenvironment …
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Stem cell matrix and cartilage regeneration
… due to its limited healing capacity. Current cell-based therapy using autologous chondrocyte implantation has been developed for decades and promising results have been observed in clinic. However, the shortage of autologous chondrocytes and their uncertain long-term effectiveness have led …
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Exploring Beta Cell NADPH production using Organelle-targeted Apollo-NADP+ Sensors
A major function of beta cells is the production and secretion of insulin to maintain glucose homeostasis. Loss of this function is directly linked to progression of diabetes. The loss of beta cell function is exacerbated by cellular senescence associated with natural aging. Senescence impacts …
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Microrna Regulation of Prostate Cancer Stem/Progenitor Cells and Prostate Cancer Development
<p>Most human tumors contain a population of cells with stem cell properties, called cancer stem cells (CSCs), which are believed to be responsible for tumor establishment, metastasis, and resistance to clinical therapy. It’s crucial to understand the regulatory mechanisms unique to CSCs, so that …
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ESPRESSIONE DI SEL1L NEL CARCINOMA MAMMARIO - CORRELAZIONI CLINICO PATOLOGICHE
Malignant cells exhibit an exceptional ability to maintain homeostasis in an hostile environment, upregulation of proteins involved in the stress response with an increase in the apoptosis resistance, and in diminishing cell senescence or permanent arrest of cell division. SEL1L is a member of …
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Utilization of fish for constitutional and acquired chromosomal abnormalities for diagnostic and prognostic purposes
… and clinical characteristics of small cell lung carcinoma (SCLC). The correlation between del(5q) and spindle cell morphology was found to be significant (p<0.025), but of unknown relevance. In the second study, FISH was used in conjunction with microarray analysis to define the …
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An investigation of insulin-like growth factor binding protein-5 (IGFBP-5) as a biomarker for the detection of early liver disease
… fibrosis of the lung. IGFBP-5 induces epithelial cell senescence, an important component in the failure to resolve healing which results in a compensatory fibrotic response. IGFBP-5 has also been identified as a tumour marker gene of interhepatic cholangiocarcinoma, a type of cancer of the bile …
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Investigating markers of accelerated aging in patients with Treatment Resistant Depression
… results from these studies suggest premature cell senescence in patients with severe depression, and that LTL and mtDNAcn may constitute disease biomarker for TRD. A potential implication of telomere dynamics in the ECT response can be suggested. Nevertheless, our limited understanding of the …
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Inhibition of pancreatic cancer progression through EMT inhibition and induction of ER stress
… metastatic and chemo-resistant nature. Cancer cell epithelial to mesenchymal transition (EMT) contributes importantly to cell invasion, metastasis, and drug resistance in pancreatic cancer. In addition, pancreatic cancer cells exhibit an elevated basal level of unfolded protein response (UPR) …
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A Tissue-Engineered Blood Vessel Model for Vascular Aging
… of atherosclerosis. In particular, endothelial cell senescence is implicated in age-related changes in vasoreactivity. Oxidative stress is considered the primary source of endothelial cell (EC) senescence in vivo. EC senescence leads to abnormal proliferation of vascular smooth muscle cells, …