Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"cell rolling"”.
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A microvillus based approach to model cell rolling
Cell rolling is a physiological phenomenon, which allows leukocytes to attach to activated vascular endothelium and reach sites of inflammation. A novel approach to model cell rolling is presented in this thesis. The model incorporates all the aspects known to be important to rolling in a …
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Experimental methods by optical trapping for investigation of leukocyte cell rolling mechanics
… the mechanical behavior of the leukocyte cell membrane as it undergoes cell rolling. Membrane tethers extracted from the cell during rolling function to slow the cell down and to maintain contact with the endothelial wall. Understanding the dynamic behavior of the leukocyte membrane during …
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The effect of P-selectin pattern width on HL-60 cell rolling behavior
… the width of P-selectin band patterns on the rolling behavior of HL- 60 myeloid cells along edges of the band patterns was studied. The P-selectin and polyethylene glycol (PEG) pattern was produced via microcontact printing using a polydimethylsiloxane (PDMS) stamp. HL-60 cells were flowed …
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Development of biomimetic microfluidic adhesive substrates for cell separation
Cell separation is important in medical, biological research, clinical therapy, diagnostics and many other areas. The conventional methods of cell sorting have limited applications due to sophisticated equipment settings, high costs, or time-intensive and labor-intensive processing steps. Inspired …
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Biomolecularly and mechanically instructive materials for guiding cell-substrate interactions
… advance our understanding and ability to guide cell fate and function. Benzophenone (BP) photolithography is uniquely suited to generating chemically and mechanically tailored materials because of its molecularly general and spatially modulated characteristics. Here, we describe the application …
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Antibody-functionalized nanoporous surfaces enable high throughput specific cell capture
Adhesion-based cell capture on surfaces in microfluidic devices forms the basis of numerous biomedical diagnostics and in vitro assays. Solid surface microfluidic platforms have been widely explored for biomedical diagnostics since samples can be precisely and reproducibly manipulated under …
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Affinity Flow Fractionation for label-free cell sorting
Capture and isolation of flowing cells from body fluids such as peripheral blood, bone marrow or pleural effusion has enormous implications in diagnosis, disease monitoring, and drug testing. However, in many situations the conventional methods of cell sorting are of limited use due to complex …
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Molecular Mechanisms of Circulating Tumor Cell Adhesion in Breast Cancer Metastasis
During hematogenous metastasis, tumor cells dissociate from a primary tumor, migrate through the tissue space, and enter the circulatory system. The circulating tumor cells (CTCs), once bloodborne, travel to distant sites, where they adhere to the endothelial cells lining the vessel wall, …