Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 43 for “"cell regulation"”.
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Dendritic cell regulation of immunity to Leishmania donovani
Dendritic cells lie at the interface of innate and adaptive immunity, critically contributing to the generation of an antigen-specific immune response. Although the mechanisms by which they initiate protective immunity are well characterised, their precise contribution to the subsequent regulation …
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Mechanism of Spermatogonial Stem Cell Regulation by ETV2
… is the process through which male germ cells give rise to spermatozoa. Spermatogenesis is initiated from spermatogonial stem cells (SSCs) which self-renew or differentiate to give rise to differentiated progenies of germ cells. Hence understanding of SSC biology is essential to …
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Dendritic Cell Regulation of Peripheral Tolerance in Polyclonal T Cell Repertoires
<p>Dendritic cells (DCs) play a pivotal role in determining whether the outcome of the immune system's encounter with antigen will be immunity or tolerance. Using an antibody against the DEC-205 receptor, antigens have been delivered specifically to DCs in vivo. Under steady state conditions, such …
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A model of sinoatrial node cell regulation by the autonomic nervous system
… of cardiac contractions, which are initiated by cells in the sinoatrial node, the "pacemaker" of the heart. The oscillation rate of these spontaneously active cells is tightly regulated by the sympathetic and parasympathetic branches of the autonomic nervous system. Our understanding of …
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Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome
… therapies available. Human Mesenchymal Stromal Cells (hMSCs) are a promising candidate therapy which are currently being investigated in clinical trials for ARDS. However their mechanisms of effects in lung injury are not fully elucidated. A fuller understanding of these mechanisms may highlight …
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Guard Cell Regulation of Stomatal Response: Chloroplast Function and Abscisic Acid Metabolism in Guard Cells of Commelina Communis and Vicia Faba
… evaluated for obtaining viable, purified guard cells by sonication of epidermal peels of Vicia faba L. and by treatment at pH 4 of epidermal peels of Commelina communis L. The guard cells were free of mesophyll cells and chloroplasts and of living epidermal cells as shown by fluorescence …
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Regulation of Galactosylceramide Biosynthesis
… thesis is to better understand the mechanisms of cell regulation determining galactosylceramide synthesis.
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PD-1 AND PD-1 LIGAND REGULATION OF NATURAL ANTIBODY SPECIFICITIES AND THE ADAPTIVE RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES
… increased in the past three decades. Programmed cell death-1 (PD-1) is a surface-expressed receptor of the B7/CD28 superfamily and the subject of considerable study since its discovery in 1992 [1]. The available literature lacks an in-depth understanding of the role of PD-1 and PD-1 ligands …
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Assessing Crosstalk Between Calcium and cAMP in Pancreatic Alpha Cells
… between insulin and glucagon. Pancreatic alpha cells release glucagon in response to a drop in blood sugar. Pancreatic alpha cells appear to be regulated through multiple signaling pathways. One potential method of regulation occurs from α-MSH or epinephrine stimulated production of the …
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Spatial and temporal control of lipid-membrane morphology induced by sphingomyelinase
… has been shown to be involved in a variety of cell regulation processes. It can convert sphingomyelin (SM) to ceramide (Cer) and has been suggested to influence the cellular processes by reorganizing the cell membrane morphology. This thesis aims at a more comprehensive understanding of how …
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Development of a single-cell fluorescence-based sensor to investigate Myc protein stability
The transcription factor Myc is expressed in cells in response to pro-growth signals and drives expression of a plethora of genes that promote proliferation. This pleiotropic activity renders loss of Myc regulation highly beneficial to tumour cells and, in fact, Myc is deregulated in most human …
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A Structure-Activity Relationship Study with Isoquinolinone Compounds and Stromal Antigen 2 Mutant Ewing’s Sarcoma Cells and Synthesis of Small Molecules for Anticancer Activity Through TEAD Palmitoylation Inhibition
… molecules that inhibit the growth of cancer cells through the Hippo signaling pathway. Ewing’s sarcoma is the second most commonly diagnosed pediatric bone cancer. While there are common forms of general treatment available, there are little to no treatments for recurrent cases, as well as …
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On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine
… regulatory enzymes in signal transduction and in cell regulation. Understanding inhibition mechanisms of kinases is important for the further development of new therapies for cancer and inflammatory diseases. I have developed a statistical approach based on the Mantel test to find the relationship …
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Ontogenic Resistance To Uncinula Necator In Developing Berries Of Grapevine (Vitis Spp.): Using Germplasm Diversity To Study The Mechanism
… for biological functions involved in metabolism, cell regulation and proteolysis. Fifty-five sequences in the newly released V. vinifera genome were also newly annotated for function, further improving this emerging genetic resource. The studies into the development of the berry cuticle as it …
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Somatic Stem Cell Populations and Studies on the Functional Role and Regulation of ABCG2
… that was identified in breast cancer cells due to its ability to efflux chemotherapeutic drugs. Abcg2 can also efflux Hoechst 33342, resulting in a side population phenotype when stained cells are sorted by FACS. Recent studies have suggested that Abcg2 may be a marker for stem and …
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Pathogenic impact of immune-related cells in Batten disease
… we examined the role of adaptive immune cells in mouse models of Infantile NCL (Ppt1-/- mice) and Juvenile NCL (Cln3-/- mice) by identifying, localising, and subsequently genetically removing immune components. Characterising the adaptive immune response within Ppt1-/- and Cln3-/- mice, …
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Catalytic and non-catalytic mechanisms involved in Glutathione S-transferase Pi mediated cytoprotection
… to antioxidant defence in the mammalian cell. Among GST, the Pi class (GSTP1) is the most prominent extrahepatic isoform in humans, and it is well documented that increased expression of this enzyme is present in human tumours and can contribute to anticancer drug resistance, involving …
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The Role of Angiopoietin-2 in Signaling Through the Endothelial Receptor Tyrosine Kinase Tie1
… shown to exhibit essential roles in endothelial cell sprouting and quiescence, the mechanistic details of Tie interactions and the effects of their associations with the Angiopoietins have not been elucidated. Studies in this thesis investigated the effects of Ang2 on Tie1 activation, signaling, …
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