Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"cell recognition"”.
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Influence of randomness in mathematical models for diffraction and T-cell recognition
… range interaction. The second part deals with recognition in the immune system. In this part the main focus lies in the probabilistic modeling itself, preparation of the mathematical tools, and the analysis to show the ability of the models to explain the reliable recognition of foreign …
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CD4+ T cell recognition of Epstein-Barr virus nuclear antigen (EBNA) - 1 in the Chinese population
… expression of EBV antigens in NPC tumour cells and the presence of EBV-specific T cells at the tumour site. More importantly, studies in other EBV-associated diseases strongly indicated that CD8+ T cell based immunotherapy targeting EBV antigens could control EBV infection and also tumour …
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Cellular and Molecular Mechanisms of Retinal Neuron Spatial Patterning
<p>During development, cell-cell recognition events mediate crucial steps in the formation of organized cellular patterns critical for tissue function. In the nervous system, cell recognition cues guide migrating neurons during development to appropriate terminal locations and sculpt their …
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Effect of heat stress of the cell wall of the yeast, Saccharomyces cerevisiae : phosphorylation of ribosomal protein S10-B brought about by enzymes of the glycolytic pathways
The cell wall is a dynamic and elastic structure that provides osmotic and physical protection to the yeast cell (l). As such, it forms the immediate site of contact between the yeast cell and its environment (2), and is essential for maintaining cell integrity and shape. Cell growth and …
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NKG2D Ligands in Cancer
<p>NK cell transplantation has been increasingly used to treat cancers that are resistant to chemotherapy. However, not all cancers are susceptible to NK cell killing. The prevalence and mechanisms of NK cell resistance have not been well elucidated. Because NKG2D is a major activating receptor on …
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The cloning , expression and characterisation of bacterial chitin-binding proteins from pseudomonas aeruginosa , serratia marcescens, photorhabdus luminescens and photorhabdus asymbiotica.
… proteins. The majority of proteins secreted by cells are modified by the attachment of oligosaccharide chains. This glycosylation event has been shown to impact correct protein folding, protein stability, solubility, to aid in cell recognition and to help regulate cell processes. In order to …
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Immunology and virology of HIV-1 infection in Cameroon
… consensus M sequences resulted in their broad recognition, but failed to identify highly immunodominant peptides between homogeneous and diverse HIV epidemics. Further refinement of these immunogens may contribute to the development of a globally relevant vaccine. Finally, the use of PTE …
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Building a Consistent Neuronetwork: Defining Molecular Cues Involved in the Synaptic Target Recognition of Drosophila Melanogaster
… synaptogenesis begins with ""synaptic target recognition"", a cell-cell recognition event in which a neuron and its target stably adhere. Herein I describe two transmembrane molecules present on a subset of muscles in the Drosophila embryonic neuromuscular system, Fas3 and Toll, that affect …
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Oncolytic viruses enhance long-term NK cell anti-tumor cytotoxicity through AP-1 and IRF pathway activation
<p>Natural killer (NK) cell therapeutics have emerged as a promising strategy in adoptive cellular therapy. While genetic modifications of NK cells can enhance their antitumor activity, modulating the tumor to augment NK cell recognition and function remains underexplored. In this study, we …
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Structure studies of the human class II major histocompatibility complex protein HLA-DR1
… in the form of short peptides within the cell and present them to the T cell receptors on the surface T cells. In this thesis work, the structural aspects of the human class II MHC protein HLA-DR1 in complex with different peptides and also in the peptide-free form were investigated. …
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The Development and Application of a Hemolytic Plaque Forming Cell Assay (PFC) and a Cytotoxic T-Lymphocyte Assay (CTL) in Tilapia (Oreochromis niloticus) for Immunotoxicity Risk Assessment of Environmental Contaminants
… testing series are the hemolytic plaque forming cell (PFC) and the cytotoxic T-lymphocyte (CTL) assays, quantitative indicators of antibody production and cell-mediated activity, respectively. The assays were modified in consideration of specific tilapian immune parameters, then tested using …
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Deconvolution of Membrane Protein-Detergent Complex Interactions
… important in many biological functions such as cell-cell recognition, transport, and signaling; yet the study of these proteins is stunted due to their excessive aggregation in aqueous solutions. Detergents have been extensively exploited to mitigate this aggregation, and accomplish this by …
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Molecular mechanisms and complete antigen formation in allergic contact dermatitis
Allergic contact dermatitis (ACD) is a common T cell mediated skin disease. Small reactive organic molecules called haptens induce ACD. Haptens are not recognized by themselves, but need to bond to endogenous proteins in the skin, and processed further into complete antigens. Antigen specific T …
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Identifying a common cause of the loser cell status in Drosophila melanogaster.
Cell competition is the process whereby less fit cells termed “losers” are selectively eliminated from a tissue by their fitter neighbors – or “ winners.” This sacrifice of aberrant cells is thought to have evolved at the advent of multicellularity to enforce cell co-operativity and ensure the …
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Statistical physics of T cell receptor development and antigen specificity
… made in understanding pertinent molecular and cellular phenomena, the mechanistic principles that govern many aspects of an immune response are not known. In this thesis, I illustrate how complementary approaches from the physical and life sciences can help confront this challenge. …
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Development of a Nanoparticle Vaccine Delivery System with Polymeric Oral Adjuvants for Poultry
… would enhance viral uptake and stimulate immune cells to produce protective immunity. This would allow the safer killed form of each virus to be used in place of modified live (MLV) viruses and avoid undesirable side effects like immunosuppression. The research objectives were to 1. Fabricate and …
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Engineering human single-chain T cell receptors
The alpha-beta T cell receptor (TCR) is responsible for mediating T cell recognition of self and non-self tissues, through recognition between a complex of a peptide and a product of the major histocompatibility complex (pepMHC) on target cells. In the immune response to cancerous tissue, the …
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Transcriptional Regulation of Clr-b (Clec2d) in Health and Disease
… disease and cancer. Natural killer (NK) cells are innate lymphocytes that recognize and eliminate pathological cells. Target cell recognition is facilitated by germline-encoded NK cell receptors, including the NKR-P1B inhibitory receptor. The NKR-P1B-ligand, Clr-b, is broadly expressed by …
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Overcoming dendritic cell-mediated suppression of T cell responses in a prostate tumor environment
… therapy is limited by the tolerization of CD8⁺ T cells in tumors, rapidly abrogating anti-tumor responses. In order to better understand the factors necessary to induce, maintain and promote productive T cell responses against cancer, this research has focused on understanding and interrupting …
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