Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1326 for “"cell proliferation"”.
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Bioenergetics and metabolism of eukaryotic cell proliferation
Cellular growth and proliferation necessitates the transformation of cell-external nutrients into biomass. Strategies of biomass accumulation across the kingdoms of life are diverse and range from carbon fixation by autotrophic organisms to direct biomass incorporation of consumed nutrients by …
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Active Inhibition of T Cell Proliferation by Monocytes
… well described in their ability to inhibit T cell activation. The most current model is that anti-class II mAb interfere directly with the T cell receptor-major histocompatibility complex crosslinking which is necessary for T cell activation. The anti-CD3 mAb, OKT3, is an MHC class II …
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Regulation of Breast Cancer Cell Proliferation by APRIL
… cause of death from cancer among women. “A proliferation-inducing ligand” (APRIL) is seen in the stroma of approximately 38% of breast cancer patients. APRIL is a tumor necrosis factor superfamily member that is implicated in lymphoid cell survival, proliferation and apoptosis. APRIL studies …
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The role of respiration in supporting cell proliferation
Compared to non-proliferating cells, proliferating cells such as cancer cells have additional metabolic requirements for generating biomass. However, despite these additional requirements the components of the mammalian metabolic network in both proliferating and non-proliferating cells are largely …
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Impact of delta-tocotrienol on human melanoma cell proliferation
… of HMG CoA reductase, suppresses the proliferation of marine B16 melanoma cells and human blood, breast, cervix, colon, liver, lung, lymph gland, nerve, pancreas, and prostate tumor cells. Dietary d-δ-tocotrienol suppresses the growth of implanted B16 melanomas without toxicity to host …
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Modeling cell proliferation in a perfusion tissue engineering bioreactor
… takes place in a bioreactor in which a cell seeded porous scaffold is placed, and the scaffold experiences a perfused flow of a nutrient-rich culture medium. The goal of the model is to assist experimentalists in evaluation of different parameter scenarios as the time needed to simulate …
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T-type calcium channels and human mesangial cell proliferation
Aberrant proliferation of human mesangial cells (MC) is a critical step in the pathogenesis of mesangioproliferative renal diseases. The T-type calcium channel (T-CaCN) has been proposed to play an important role in the proliferation of a number of non-excitable cell types, but T-CaCN expression …
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Systemic and local signalling regulating neural stem cell proliferation
Neural stem cells (NSCs) in the brain can be reactivated to exit quiescence and generate new cells in response to injury or disease. Determining the specific signals involved in NSC reactivation is essential to understanding neural regeneration. Investigating NSCs in *Drosophila melanogaster* …
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Inhibition of Cell Proliferation through Regulated Intramembrane Proteolysis of CREB3L1
CREB3L1/OASIS is a cellular transcription factor synthesized as a membrane- bound precursor and activated by regulated intramembrane proteolysis in response to stimuli like ER stress. By comparing gene expression between Huh7 subclones that are permissive for hepatitis C virus (HCV) replication …
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Targeted Epigenetic Editing to Increase Adult Pancreatic Β-Cell Proliferation
β-cell replacement therapy is potentially a curative approach in treating diabetes, as demonstrated by the success of pancreatic islet transplantation in type 1 diabetes. However, there are an insufficient number of organ donors to meet the demand of this disease, which is increasing in prevalence. …
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Modulation of hepatic cell proliferation in 2-Butoxyethanol treated mice
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Estrogenic and Antiestrogenic Regulation of Cell Proliferation and Tissue Growth
… were investigated in human breast cancer cells and in the rat uterus. I studied the regulation of ornithine decarboxylase (ODC) activity and polyamine concentrations by E2 and antiestrogens (AE) as an aid to understanding the dissimilar effects of E2 and AE on uterine growth. Both E2 and …
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Novel Roles of Gastrin and Cholecystokinin in Islet Beta Cell Proliferation
… share a common theme: an insufficient beta cell mass to maintain glucose homeostasis. In Type 1 diabetes this deficiency arises from autoimmune destruction of the beta cells. In the latter stages of Type 2 diabetes, there is a precipitous drop in beta cell mass, resulting from the …
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Inhibition of MCF-7 Breast Cancer Cell Proliferation by Diarylthiourea Analogs
<p>No abstract available</p>
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The role of phosphoglycerate dehydrogenase in cell proliferation and tumor progression
The metabolic needs of proliferating cells are distinct from those of quiescent, terminally differentiated cells. Cancer is a disease of inappropriate cell proliferation, and tumor cells require a unique metabolic program to support proliferation. Phosphoglycerate dehydrogenase (PHGDH) catalyzes …
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The Role of Oxytocin in Bovine Satellite Cell Proliferation and Differentiation
… that OXT may play essential roles in satellite cell (SC) proliferation and differentiation, which further contribute to skeletal muscle development and growth. In this dissertation, we tested this hypothesis with in-vivo and in-vitro studies in intrauterine growth restriction (IUGR) sheep, …
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Mechanism of genistein in the regulation of pancreatic beta-cell proliferation
… derived primarily from legumes, on pancreatic β-cell proliferation and the related molecular mechanisms. Diabetes mellitus is a major and growing public health problem worldwide. Both in type 1 (T1D) and type 2 diabetes (T2D), the deterioration of glycemic control over time is primarily caused by …
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Investigating the role of Notch signalling during mesoderm development and cell proliferation
Communication among cells drives organismal development and homeostasis in all multicellular organisms. Understanding how cells communicate with one another is critical to understanding mechanisms underlying developmental and diseases processes. The Notch signalling pathway is a …
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Nutrient-induced intestinal epithelial stem cell proliferation and its effect in obesity
The student, Weinan Zhou, accepted the attached license on 2018-06-27 at 20:50.
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