Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"cell processes"”.
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Maguk Scaffolds Organize A Key Synaptic Complex In Horizontal Cell Processes Contacting Photoreceptors
<p>Synaptic processes and plasticity of synapses are mediated by large suites of proteins. In most cases, many of these proteins are tethered together by synaptic scaffold proteins. Scaffold proteins have a large number and typically a variety of protein interaction domains that allow many …
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Electron microscopic studies of mitotic chromosomes in yeast
… to determine many of the components involved in cell processes such as cell cycle control and secretion. One of the unresolved problems in yeast cell biology is whether or not the chromosomes of the yeast, Saccharomyces cerevisiae, condense during mitosis and, if they do, to what extent they are …
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A potential biologic role for the meniscus in the development of osteoarthritis.
… characterized the alterations in meniscus cell processes between normal and osteoarthritic menisci, and explored potential pathways involved in osteoarthritis pathogenesis including a novel pathway proposed to mediate osteoarthritis development.
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Aquaporin 4 and Kir4.1 Distribution in Retinal Glial Cells of Normal Macaque Eyes and Eyes with Experimental Glaucoma
… to glutamine synthetase (GS, a marker for Müller cells), and a polyclonal antibody to glial fibrillary acidic protein (GFAP, a marker for astrocytes and reactive Müller cells). Antibody binding in retina was visualized with the appropriate secondary antibody conjugate of fluorescein, Cy3 and Cy5. …
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Triggerable ligand presentation using caged-RGD
Cells rely on time-dependent binding and activation by the ECM to initiate downstream signal transduction. It is unknown whether adhesion to a ligand is required throughout various cell processes, or only during a specified time period ("temporal threshold”). Current approaches to ligand …
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Genome-wide microscopy screening identifies links across processes including a conserved connection between DNA damage control and the microtubule cytoskeleton
… high-content microscopy screening of a cell library consisting of over 3000 single mutant strains of the fission yeast, Schizosaccharomyces pombe. Each strain has one nonessential gene knocked-out, allowing investigation of the resulting phenotypes. I report the implementation and …
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Product and host engineering for low-cost manufacturing of therapeutic proteins in the yeast Komagataella phaffii
… proteins are manufactured in either bacterial cell processes, which require bespoke purification processes to separate the product from cellular lysates, or in mammalian cell processes, which require long development timelines, stringent sterility requirements, and expensive feedstocks, all of …
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Development of Specific and Potent α-Helical Inhibitors and Probes of Cysteine Proteases
… interest due to their diverse roles in cellular processes and diseases. However, it has been difficult to design inhibitors for use in determining their individual roles due to the conserved active site. Interestingly, each protease has an endogenous inhibitor that forms an α-helix at …
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Global Existence of solutions to Reaction-Diffusion Systems with Mass Transport type Boundary Conditions
… type of system arises in mathematical models for cell processes.
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Modeling and simulation of the equilibrium and nonequilibrium dynamics of DNA
… and transfer of genetic information in living cells. The cell processes by which genetic information is stored, copied or transcribed induce forces and torques in DNA that alter its structure. These structural changes are dynamic and are capable of both inhibiting and facilitating some of these …
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Regulation of Inverted Formin-1 (INF1) by Microtubule-Affinity Regulating Kinase 2 (MARK2)
… plays a critical role in the establishment of cell polarity. Cell processes like mitosis and migration rely on the reorganization of the cytoskeleton to properly function. One driver of cell polarity is the formin, Inverted Formin-1 (INF1). INF1 is able to induce F-actin formation, activate the …
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Analyse verschiedener Netzhautkulturmodelle an der Netzhaut vom adulten Hausschwein
… as well as glial interactions and molecular processes. In the present work different retina tissue culture systems from the adult porcine eyes were examined by immunohistology and results compared to freshly isolated retina as positive control. The control retina displays histological …
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Development of microfluidic devices to maintain and interrogate tissue biopsies - biomedical applications
Currently most cell-based methodologies in microfluidic systems utilize homogeneous or heterogeneous cell populations. However, these systems do not present an accurate representation of in vivo dynamics. A microfluidic based experimental methodology has been developed that offers a biomimetic …
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Endotelinių mikrodalelių tyrimas pirminėje ląstelių kultūroje /
… shed from activated or apoptotic endothelial cells and carry inside a variety of proteins and genetic material that may influence the cell processes. They play a role in coagulation, inflammation, endothelial function, and angiogenesis and thus may be marker for early vascular diseases. In the …
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Repair of DNA-protein crosslinks in mammalian cells
… repair of DNA-protein crosslinks in mammalian cells. DNA-protein crosslinks (DPCs) are bulky lesions which disrupt important cell processes such as transcription and replication. They are formed by endogenous molecules such as formaldehyde and exogenous damaging agents such as ionizing …
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ADDUCINS AFFECT CORTICAL NEUROGENESIS BY REGULATING PROGENITORS¿ MORPHOLOGY AND FATE
… embryogenesis with the main neural progenitor cells, classified as apical (APs) and basal progenitors (BPs). BPs are significantly enriched and highly proliferating in gyrencephalic species compared to lissencephalic, leading to an increased neuronal outcome and to cortical folding. BPs are a …
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Interaction of the DNA -Bound Estrogen Receptor With Coregulatory Proteins
… complexes reveal proteins involved in several cell processes including, transcription, DNA repair and replication, G-protein modulation, and scavengers of superoxide radicals. Investigation of the association of ERalpha with the DNA repair protein, 3-methyadenine DNA glycosylase (MPG) reveals …
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Toxoplasma gondii-mediated Host Cell Transcriptional Changes Lead to Metabolic Alterations Akin to the Warburg Effect
Toxoplasma gondii is an obligate intracellular parasite, that is able to infect any nucleated cell. An important global pathogen, T. gondii can cycle between primary and secondary hosts, thus enabling widespread penetrance. Within its intracellular niche – a membrane-bound parasitophorous vacuole – …
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Identification and characterization of rickettsial proteins at the host-pathogen interface
Bacterial pathogens subvert host cell processes during infection by secreting protein effectors that manipulate host machinery. Cataloging such effectors has enabled a deeper exploration of the molecular basis of disease for numerous pathogens. Members of the Rickettsia genus are obligate …
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Differentiating noise and modulators in artificial neural networks
… to fine-grain representations of neurons and cell processes. One feature that the different approaches share, is that they are all in relative infancy. Thus, most research concentrates on gross aspects of neural communication and methods of computational simulation. Recently, some clues have …
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