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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"cell plasticity"”.
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Mechanical and epigenetic regulation of cell plasticity and tumorigenicity
Made available in DSpace on 2015-09-29T21:08:15Z (GMT). No. of bitstreams: 2 SINGH-THESIS-2015.pdf: 283696 bytes, checksum: 0f7e963da95634dafa16e9e9a970da45 (MD5) LICENSE.txt: 4208 bytes, checksum: dd735d55c1189c6cc1ef21be4dc1ab2c (MD5) Previous issue date: 2015-07-22
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Epithelial cell plasticity in chronic liver disease (MASLD/NAFLD)
… direct differentiation or via a progenitor cell population (Michalopoulos & Khan, 2015). However, the reality of this process in a disease context especially in human remains to be fully demonstrated while the molecular mechanisms involved have not been investigated in detail. Here, I …
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Tracing clonal cell plasticity in the microenvironment of pancreatic ductal adenocarcinoma
The pancreas may regenerate without stem cells by induction of cellular plasticity between differentiated cells. Although essential for the remarkable capacity for pancreas regeneration, this property entails a vulnerability to cancer through acinar-to-ductal metaplasia and dedifferentiation by …
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A genome-wide, single-cell analysis of vascular smooth muscle cell plasticity
Vascular smooth muscle cells (VSMCs) possess a remarkable capacity to change phenotype in response to injury or inflammation. In healthy arteries, VSMCs exist in a contractile state, but upon vascular inflammation or injury, they can switch into an activated state, in which they downregulate the …
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Dissecting adult epithelial cell plasticity using a model of oesophageal-to-skin lineage conversion
Epithelial cells possess a remarkable capacity to rapidly adapt their cell fate programme in response to changing tissue demands. Upon tissue injury or environmental perturbations, adult committed cells can reacquire stem cell properties, thereby expanding the pool of cells that contribute to …
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Endothelial cell plasticity as a marker of vascular disease and predictor of adverse outcomes to stress
Endothelial cells (ECs) dynamically sense and adapt to their local biomechanical and biochemical environments, a process crucial for maintaining vascular homeostasis. Loss of this plasticity is implicated in vascular diseases, where endothelial dysfunction and maladaptive responses exacerbate …
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Understanding tumor cell plasticity in spatial transcriptomics with graph attention networks and walk-based pseudotime analysis
Tumor cell plasticity in cancer is a key driver in tumor progression, heterogeneity, metastasis, and treatment resistance. Tumor cells change states from the conventionally easier to treat epithelial state to the more resistant mesenchymal state. Understanding the transition dynamics of these …
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Molecular mechanisms of neural stem cell plasticity and neuro-regeneration in an Alzheimer’s-like neurodegeneration model of adult zebrafish
… and neurogenic ability of neural stem cells (NSCs), which normally produce neurons, albeit rather a limited lineage. Recently, in AD patients, neurogenic outcome was shown to reduce dramatically (Moreno-Jimenez et al., 2019; Tobin et al., 2019). This lack of neurogenic input from NSCs …
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The Role of the Transcription Factor CEBPA in Regulating Lung Alveolar Type 2 Cell Fate In Vivo
<p>Cell plasticity can extend across all possible cell types, yet it naturally diminishes as cells progress through differentiation. This plasticity can be reactivated during injury repair, engaging developmental flexibility. Our investigations reveal the critical role of the transcription factor …
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Integrative multi-omics dissection of cancer cell states and susceptibility
Cancer cells are characterized by a broad spectrum of unique genetic, epigenetic and transcriptional states, which are often concomitant with high degrees of plasticity in cell identity. These cell states and the fluidity therein are a major source of resistance to both chemotherapy and targeted …
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The oligodendrocyte lineage of the median eminence in the adaptation to diet-induced obesity
… resides a population of oligodendrocyte lineage cells which display a uniquely high degree of plasticity; Typically, populations of oligodendrocytes are long-lived, supporting their role in myelinating neuronal axons and providing trophic support to neurons. Meanwhile, oligodendrocyte progenitor …
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Role of ATRX in colorectal cancer metastasis
… established by the Myant lab as a mediator of plasticity and non-canonical cell states, TGFβ-induced epithelial-to-mesenchymal transition (EMT), and invasion in CRC. These characteristics are thought to promote aggressive and metastatic disease; therefore, the first aim of my project was to …
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Molecular Mechanisms and Antigen Receptor Requirements for Lymphocyte Adaptation to Intestinal Tissues
… excretion. It contains the most populous immune cell reservoir in the body and is continuously exposed to a large and diverse number of diet- and microbiota- derived antigens. The highly stimulating luminal environment is separated from the core of the body, the lamina propria (LP), by just a …
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PROBABILISTIC AND DEEP LEARNING APPROACHES TO MODELING BIOLOGICAL SYSTEMS
… patterns. The second part deals with single-cell and multi-omic data integration, as well as the study of cancer cell plasticity and resistance to therapy. I present MIDAA, a deep archetypal analysis method that provides interpretable latent representations and show its performance on two …
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CROSSTALK BETWEEN PRC1 AND PRC2 IN INTESTINAL LINEAGE COMMITMENT AND CELL IDENTITY
… Complexes 1 and 2 (PRC1 and PRC2) control cell identity by establishing facultative heterochromatin repressive domains at common sets of target genes, from the early stages of development to adulthood. How they functionally preserve transcriptional silencing has been deeply explored in …
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ASCL2 Positive Tumor Cells Modulate the Response of Metastatic Colorectal Cancer to MAPK-Targeting Therapy
… revealed a dynamic, proliferative, stem-like cell state with increased tolerance to MAPKi therapy. Additionally, MAPKi therapy resulted in tumor cell induction of ASCL2<sup>+</sup> phenotype resulting in enrichment of ASCL2<sup>+</sup> cells. Finally, depletion of the ASCL2<sup>+</sup> …
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Identification of the role of transcription factor ETV7 in breast cancer aggressiveness
… of ETV7 in promoting breast cancer stem-like cell (BCSC) plasticity and resistance to chemotherapy in BC cells. We observed that ETV7 repressed a large panel of interferon response genes and increased BCSC cell plasticity, leading to resistance to 5-fluorouracil. Then, we investigated the role …
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Discovery of microenvironment drivers of cell states, plasticity and drug response
Cell state can be influenced by both intrinsic and extrinsic factors with functional consequences. Illustratively, in cancer, intrinsic genome level alterations or extrinsic microenvironmental immune cell activity can drive tumorigenesis. Similarly, in viral infections like COVID-19, the responses …
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Dissecting cell-autonomous and microenvironmental factors governing lymphatic metastasis in breast cancer
… or lymphatic system. The presence of tumour cells in the draining lymph node (lymph node involvement) represents the most important prognostic factor for breast cancer patients. Despite its clinical implications, the mechanisms governing lymphatic metastasis remain poorly understood. This …
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