Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 80 for “"cell physiology"”.
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Cell physiology based pharmacodynamic modeling of antimicrobial drug combinations
… these models typically lack a representation of cellular processes and cell physiology, the mechanistic integration of drug action is not possible on the cellular level. The cellular mechanisms of drug action, however, are particularly relevant for the prediction, analysis and understanding of …
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Place cell physiology in a transgenic mouse model of Alzheimer's disease
… impairments (Selkoe, 2001). Hippocampal place cells are a well understood candidate for the neural basis of one type of memory in rodents; these cells identify the animal's location in an environment and are crucial for spatial memory and navigation. This PhD project aims to clarify the …
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Mechanical influence of pressure, topography, and diffusion on cell physiology and function
… of pressure, topography, and diffusion on cellular function and physiology. Pressure is one form of mechanical stimuli that occurs naturally within a cellular microenvironment yet is largely overlooked in day to day cell culture. Here we present two different pressurized incubation chambers …
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IDENTIFICATION OF MICROBIAL FUNCTIONS INTERFERING WITH HOST-CELL PHYSIOLOGY: A QUICK VIEW INTO STREPTOCOCCUS THERMOPHILUS METABOLIC POTENTIAL
… biomass production phase, without compromising cell viability. Within just 30 minutes, activated cells exhibited up to a 30% increase in lactose conversion, compared to not-activated cells. Interestingly, in the presence of both urea and a carbon source, lactic acid release was significantly …
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Control of Neuroendocrine Cell Physiology by a Single Transcription Factor, Drosophila Basic Helix Loop Helix Regulator DIMMED
<p>Neuroendocrine cells feature a large capacity for the processing, accumulation and regulated release of bioactive peptides and peptide hormones. The ultrastructural correlate of this regulated secretory pathway is a specialized organelle, called a dense core vesicle: DCV). DCVs are typically …
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Identifying the molecular components that matter: a statistical modelling approach to linking functional genomics data to cell physiology
… are predictive of the physiological state of a cell or tissue. In this thesis, a truly multivariate variable selection framework using diverse functional genomics data has been developed, characterized, and tested. This framework has also been used to prove that it is possible to predict the …
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Investigating the Enteroendocrine - Brain Axis: Ghrelin Cell and ECL Cell Physiology and Ghrelin Action on Mood and Complex Eating
… on mood and complex eating behaviors. At the cellular level, little is known about the ghrelin cell's transcriptional profile, its secretory products other than ghrelin, and its relationship to other gastric endocrine cells, such as the histamine producing enterochromaffin-like cell. My …
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Relationship of Helicobacter pylori virulence to gastric pathology in the Western Cape
… virulent fingerprint to alterations in gastric cell physiology and cell cycle events. Initially, the "virulence profile" of 109 isolates from 86 patients with a spectrum of clinically significant gastroduodenal diseases was investigated.
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Optimising microalgal lipid productivity for biodiesel production
… limitation, and different N culture regimes, on cell physiology and lipid productivity in Chlorella vulgaris.
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FUNCTIONAL DISSECTION OF ADIPOKINETIC HORMONE PRODUCING CELLS
… action, however, little work has explored AKH cell physiology and the mechanisms that govern AKH release.
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Regulation of Ammonia Assimilating Enzymes in the Ruminal Bacteria Selenomonas Ruminantium and Succinivibrio Dextrinosolvens
… dilution rate and growth-limiting nutrients on cell physiology, efficiency of growth and ammonia assimilating enzymes. Culture viability was decreased at low dilution rates for both growth-limiting conditions, but the decrease in viability was more severe in glucose-limited cultures. Cell …
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Determining how variations in cell and nuclear size contribute to mitosis and tumorigenicity in cancer cells that undergo whole genome doubling
… leads to the accumulation of aneuploidy in human cells and is sufficient to induce tumorigenesis in mice. While the genomic effects of WGD are well established, the morphological alterations that accompany WGD, such as changes to cell and nuclear size, and their functional consequences are less …
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The function and structure of the entorhinal cortex in mild cognitive impairment
… tests. The basis of such tests on single cell physiology and their comparability with behavioural tasks used in animal models of disease, confers additional advantages for translational research aimed at understanding the mechanisms linking pathological spread, disruption of cell …
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Gluconeogenic FBP1 plays a key metabolic role in activated T cells
… is active in liver, kidney and skeletal muscle cells. This study suggests that FBP1 plays a novel non-gluconeogenic role in T cells. Targeted metabolomics using [13C]-6-glucose revealed a labeling pattern of F6P in stimulated CD3+ T cells that could only have resulted from FBP1 enzymatic …
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FREQUENCY AND AMPLITUDE CONTROL OF CORTICAL OSCILLATIONS BY LIPID METABOLISM
… of signaling factors are of great importance to cell physiology in single and multicellular systems. Currently, majority of the studies focus primarily on cytoskeleton-dependent feedbacks. In contrast, information on signaling mechanisms upstream of the actin cytoskeleton remains unclear. In my …
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Interaction of zinc with the yeast <i>Saccharomyces cerevisiae</i>
… example, it activates many enzymes, acts as a cellular membrane stabiliser and is a constituent of the zinc finger proteins that bind specific DNA sequences, playing a critical role in gene expression and genome modification. The present study has focused on the influence of zinc on cell …
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The influence of zinc on the physiology of industrial strains of <i>Saccharomyces cerevisiae</i>
… whereby the ions are associated with the cell wall. This stage of uptake is often referred to as biosorption and zinc uptake is influenced by temperature, pH, biomass concentration and the presence of competing ions. The second phase of zinc uptake (metabolism-dependent metal ion …
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DECODING CELLULAR AND TEMPORAL VARIABILITY IN HUMAN CORTICAL DEVELOPMENT. INTEGRATING SINGLE-CELL TRANSCRIPTOMICS ACROSS DEVELOPMENTAL STAGES AND EXPERIMENTAL MODELS.
… and representation. Recent advances in single-cell profiling have provided a wealth of data on fetal and adult human cortex cells, but extracting insights from this information remains a significant hurdle. To address this challenge, we present NeuRoDev, an innovative analytical and data …
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Detection of SK2 Channels on Hippocampal Neurons
… 2008). Despite the recent progress on SK channel physiology, the precise spatial organization of SK channels in neurons has remained unknown. Such knowledge is critical as the subcellular distribution of SK channels is an important determinant of neuronal excitability. Currently, there are no …
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Characterisation of the expression profile and endothelial function of Rho GTPase RhoJ
… molecular switches that regulate many aspects of cell physiology. A number of Rho GTPases are essential for the formation of new vessels from pre-existing ones, a process known as angiogenesis. RhoJ/TCL belongs to the Cdc42 subfamily of Rho GTPases. Previous bioinformatic and primary cell line …
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