Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"cell patterning"”.
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Cell Patterning: Building Living Neural Networks
… growth can be controlled in vitro by plating cells at low density and by differential adhesion between the cell and substrate. This principle was used to develop a technology to pattern neurons in reduced networks consistent with recording from extracellular electrode arrays. The goals were to …
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Cell patterning technology for controlling the stem cell microenvironment
Embryonic stem cells serve as powerful models for the study of development and disease and hold enormous potential for future therapeutics. Yet, over two decades after mouse embryonic stem cells (mESCs) were first isolated, there is still little known about the role of cell-cell signaling in …
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Evaluation of layer-by-layer assembly of polyelectrolyte multilayers in cell patterning technology
… in controlling the spatial adhesion of living cells. An overview is presented on current developments and competing technologies within research and industry with respect to cell patterning and cell-based devices. Interviewed individuals in research and industry suggested a variety of potential …
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Abnormal cell patterning at the cortical gray-white matter boundary in autism spectrum disorders
… columnar organization indicates the presence of cell patterning alterations within the cerebral cortex of individuals with autism spectrum disorders (ASD). These patterning abnormalities include irregularities at the gray-white matter boundary and may implicate early neurodevelopmental events …
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Additive Manufacturing for Robust and Affordable Medical Devices
… to reduce the cost of lab-based technologies. Cell patterning technology is a target of interest for applying more cost-effective technologies, as elucidation of the variables defining cell patterning and motility may help explain the mechanics of cancer and other diseases. Through the use of a …
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Effects of stiffness gradient and hydrostatic pressure on cell migratory behaviors
… explores the effects of mechanical stimuli on cell patterning and behavior, which may influence our understanding of in vivo processes such as morphogenesis, wound healing, disease progression, tumor formation, and metastatic events. We begin by looking at the effects of a stiffness gradient in …
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Design of a microscopy-based screening method for stomatal development genes in <i>arabidopsis thaliana</i>
… stomata are also useful for research into cell patterning, differentiation, and development. The purpose of this project was to create a reverse genetics, microscopy-based screening method to identify Arabidopsis genes important in guard cell development. It was hypothesized that gene …
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System to study colony-colony interactions in embryonic stem cells
… involved in self-renewal of embryonic stem cells (ESCs). Recent studies suggested that different autocrine factors exist in murine ESCs (mESCs) and can influence their self-renewal and proliferation, predominantly in deficiency conditions. These observations were investigated based on a …
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A general method for studying autocrine signaling and its impact on cancer cell growth
… self-sustaining growth signals to cancer cells. Since the introduction of the autocrine hypothesis in 1980s, the contribution of autocrine signaling in cancer medicine has been limited to cancer tissues with adequately characterized mitogenic pathways. Its closed-loop nature and complex …
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From developmental biology to tissue-engineering: printing blood vessels
… and interfere with, rather than guide, direct cellcell interaction as well as assembly and alignment of cell-produced extracellular matrix. Understanding the physical principles of biological self-assembly is thus essential for developing efficient strategies to build living tissues and organs. …
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Biological applications of weal polyelectrolyte multilayers
… multilayers with specific emphasis on cell patterning, drug delivery, and antibacterial coatings. All of these very different applications were studied using three different polymers - polyacrylic acid (PAA), poly(allylamine hydrochloride) (PAH), polyacrylamide (PAAm). The first part of …
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Exploring the diversity of epidermal pavement cell shapes
Pavement cells in the leaf epidermis can exhibit a wide variety of shapes. Undulations in the anticlinal cell wall are a particularly interesting feature present in many model species: for example, Arabidopsis thaliana, tobacco and maize; but absent in others, like Brachypodium distachyon. …
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In vivo imaging and morphogenesis of butterfly scale development
… label-free, in vivo visualization of scale cell growth in Vanessa cardui pupae throughout pupal development. This continuous visualization of scale cells establishes a clear phenomenological timeline of scale morphogenesis that was previously limited by the discrete nature of ex vivo studies …
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Investigations on the influence of CO2 on leaf epidermal development in Arabidopsis thaliana
… the growth cycle. During leaf development, cell patterning, cytological features and epicuticular wax deposition respond dynamically to environmental factors including CO2 concentrations (p[CO2]). Gas exchange is controlled by stomata, epidermal pores flanked by a pair of guard cells that …
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Engineering and optimizing physiological cell isolation via the secondary anchor targeted cell release system
… and differences in biomarker expression on cells. Quantification of these biomarkers, then, would allow a methodology for designing personalized treatments and regimens that the patients would no longer be resistant to. However, techniques designed to purify or isolate cells to quantify …
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Exploiting the Interplay of Acoustic Waves and Fluid Motion for Particle Manipulation
… Especially when handling small objects, e.g., cells, nanoparticles, C. elegans, and zebrafish larvae, the native environment involved is mainly liquid. During the acoustic propagation inside the liquid, fluid motion will also be initiated and will influence the object movement in addition to …