Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"cell painting"”.
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Using Cell Painting and Chemical Data for Small-molecule Bioactivity and Toxicity Prediction
… predictions. The most popular among them is the Cell Painting assay, has been used alone or in combination with other - omics data to decipher the mechanism of action of a compound, its toxicity profile, and many other biological effects. Traditional approaches in drug discovery primarily rely on …
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Using Heterogeneous Information Sources for Understanding and Predicting Biological Effects of Compounds
… chapter, “Comparison of Structural Chemical and Cell Morphology Information for Multitask Bioactivity Predictions”, provided insights in which type of compound information is more useful in target prediction across 224 targets. The comparison was performed using cell morphology information (in …
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Cross-Modality Profiling of High-Content Microscopy Images with Deep Learning
… in high-content phenotypic screening of cells treated with compounds or genetic perturbations produces a large amount of high-dimensional data. One example which we focus on in this thesis is Cell Painting, a standardized pipeline used to capture rich cell morphology. Typically, …
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High throughput measurement and perturbation of tissues and tissue-derived cellular models
Human tissues are composed of trillions of cells whose states and interactions drive health and disease. Deciphering which cells and interactions are associated with any given disease is challenging due to the vast complexity of a tissue. Successfully doing so requires a suite of tools for …
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Using Chemical Probes to Examine Cellular Activities
… are valuable tools for investigating rapid cellular processes, such as anaphase in cell division, by allowing for the modulation of protein activity over the course of minutes. In addition, resistance to chemical probes by mutation can provide insight into inhibitor binding interactions and …