Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"cell of origin"”.
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Utilization of deep learning to accurately determine cell of origin in canine follicular and medullary thyroid carcinomas on routinely processed, H&E-stained tissue sections
… published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
… chromosomal translocation is present in 5% of acute lymphoblastic leukemia (ALL) cases and leads to expression of the oncogenic transcription factor, E2A-PBX1. Although t(1;19) is exclusively associated with pre-B ALL in clinical cases, murine models produce myeloid or T-lymphoid leukemias, …
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Understanding the Role of Delta-catenin in Virus-Positive Merkel Cell Carcinoma
Merkel Cell Carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer often driven by the integration of Merkel cell polyomavirus (MCPyV) into the host genome and the persistent expression of its viral oncoproteins, small tumor (ST) antigen and truncated large tumor (t-LT) antigen. However, …
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Mouse models of lung cancer : understanding the molecular and cellular basis of lung tumorigenesis
Lung cancer is the leading cause of cancer deaths worldwide. Patients are typically diagnosed with advanced disease and have a high fatality:case ratio. Despite its prevalence, the identity of the cell of origin, precursor lesions and stages of disease progression have not been well characterized …
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The origin and properties of pro-oncogenic fields in the intestinal epithelium
… epithelium is maintained by intestinal stem cells that replace each other stochastically over time. Stem cells that are excluded from the stem cell pool will differentiate into the absorptive or secretory cell lineages. However, intestinal cell-fate specification is not always restrictive and …
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Automatic Tumour Typing based on Patterns of Somatic Passenger Mutations
In cancer, a tumour’s cell of origin is the strongest determinant of its clinical behaviour. While cell of origin is typically clear at the time of diagnosis, 3-5% of cancer patients present with a metastatic tumour and no obvious corresponding primary tumour. Despite advances in molecular testing, …
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Towards a blood-based biomarker for remyelination: Glial cell death and associated byproducts in demyelinating disease
Over the past few decades, an explosion of interest in the use of accessible biofluids to identify and track molecular disease has revolutionized the fields of oncology, prenatal medicine, and others. Technological advances in signal detection and epigenetic profiling have allowed for novel …
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Identification and Molecular Analysis of Dna In Exosomes
… its packaging into exosomes is dependent on the cell of origin. Furthermore, through a rigorous assessment of various isolation methods, we identify Size Exclusion Chromatography (SEC) as the best method for the isolation of exosomal DNA for downstream applications. Additionally, we evaluate the …
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Investigating the Role of ZNF384 Rearrangements in Acute Leukemia
… involving ZNF384 are the defining lesion in 5% of pediatric and adult B-cell acute lymphoblastic leukemia and tumors are characterized by aberrant myeloid marker expression. Additionally, ZNF384 rearrangements are the defining lesion in nearly half of pediatric B/myeloid mixed phenotype acute …
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Examining the roles of the pyruvate kinase isoforms, PKMI1 and PKM2, in systemic metabolism and tumor development
Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of pyruvate kinase, and PKM2 expression is closely linked to embryogenesis, tissue regeneration, and cancer. PKM1 expression, on the other hand, is restricted mostly to skeletal muscle, heart, and brain. To …
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Investigating The Role of The P63 Isoform Δnp63 In Lung Stem Cell Populations and Lung Cancer
<p>Cell of origin studies have determined separate populations of lung progenitor cells that give rise to lung adenocarcinoma and squamous cell carcinoma. ΔNp63 is known to regulate lung development but its role in lung cancer progression remains unclear. We utilized a ΔNp63-specific conditional …
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Insights into transcriptional regulation from natural and induced variation in closely related species
Despite years of research, numerous aspects of gene regulatory mechanisms and their contributions to shaping phenotypic characteristics remain elusive. In this thesis, I gain insights into mechanisms of transcriptional regulation, focusing particularly on the binding activity of transcription …
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Elucidating Targetable Genetic Vulnerabilities in Relapsed/Refractory Diffuse Large B-cell Lymphoma
Diffuse large B-cell lymphoma (DLBCL), the most prevalent form of non-Hodgkin lymphoma is marked by significant heterogeneity in its morphology, genetic irregularities, and clinical behavior. Current prognostic tools, including the International Prognostic Index and cell-of-origin transcriptional …
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Pocket protein family function in mesenchymal tissue development and tumorigenesis
pRB is a member of the pocket protein family, which includes the closely related proteins p107 and p130. The pocket proteins are critical regulators of the cell cycle and function to restrain proliferation by controlling the activity of the E2F family of transcription factors. The pocket proteins …
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Normal cell signals in human cancer transcriptomes
Cancer cells arise from normal cells, and may retain transcriptional patterns present in the cell of origin. Recent advances in single-cell transcriptomics have allowed us to profile both normal and cancer cells at a single cell resolution, enabling direct comparisons between the two. Such …
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Molecular signatures underlying the tumourigenic transformation in a CEBPA mutated model of leukaemia
Comprehensive genetic profiling and advances in sequencing studies have enabled the identi- fication of mutations and chromosomal rearrangements frequently found in Acute Myeloid Leukaemia (AML). However, understanding the individual and synergistic impacts of these aberrations on the development …
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Identification and Utility of Dna In Exosomes
… rates but remain unavailable for a majority of cancers due to a lack of sensitive biomarkers or numerous limitations associated with current diagnosis strategies. Approaches to develop “liquid biopsies” by detecting tumor cells or DNA in the blood have led to several breakthroughs and create …
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Prostate Cancer Stem Cells: Drug to lerance, Experimental Reconstitution and Castration Resistance
<p>Prostate cancer (PCa) is one of the leading malignancies affecting men in the Western world. Although tremendous effort has been made towards understanding PCa development and developing clinical treatments in the past decades, the exact mechanisms of PCa are still not clearly understood. …
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Deconvolution of Leukemic Evolution Through Initiation, Progression and Relapse
Significant advancements in the study of the genomic architecture of B-cell acute lymphoblastic leukemia (B-ALL) have been made, but our understanding of the mechanisms of leukemic initiation and progression remain limited. To gain clarity on these processes, a deeper understanding of the …
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Investigating the initiation and progression of small cell lung cancer
Small cell lung cancer (SCLC) comprises 18% of all lung cancer cases and is an aggressive disease with a five-year survival rate of less than 5%, mainly due to the advanced nature of the disease at the time of diagnosis. Despite the need to better understand this disease, the genetic lesions that …
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