Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"cell nuclei"”.
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Initiation and organization of the DNA replication in mammalian cell nuclei
Contains fulltext : mmubn000001_049070746.pdf (Publisher’s version ) (Open Access)
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The isolation of syaptic myonuclei and Schwann cell nuclei for DNA analysis from human skeletal muscle
… alterations in gene expression of synaptic myonuclei and terminal Schwann cells and the development of a highly-regulated synaptic structure. To understand neuromuscular junction abnormalities associated with cerebral palsy, a method for assessing the regulation of gene expression in …
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Topology of Genes in Mammalian Cell Nuclei with Special Emphasis on the MLL Gene and Its Translocation Partners
… partners in the interphase nucleus of various cells cultured under different conditions, as well as in cell lines carrying translocation involving these genes. An analysis procedure was developed to precisely determine gene positions in the 3D space of the spherical interphase nucleus of …
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Ribose nucleic acid and the cell nucleus
1. Methods of estimation of ribose nucleic acid are discussed and a reliable method for the estimation of that substance in isolated cell nuclei described.
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A flow cytometry-based method for gene expression profiling of CNS cell types
… for profiling gene expression of specific cell types in the central nervous system (CNS), called fluorescence activated nuclei sorting (FANS). FANS utilizes flow cytometry to isolate cell nuclei from CNS subtypes and microarray analysis of nuclear mRNA. When compared to an existing …
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Effects of Stress, Circadian Rhythms, and Dietary Sodium on Brain Cell-Nuclear Uptake of Aldosterone and Corticosterone (Steroid Receptors)
… (ALD) and corticosterone (CORT) in brain cell-nuclei has been implicated as a necessary step in the behavioral and physiological actions of these hormones. In vivo uptake of radioactively labeled ALD and CORT in adrenalectomized (ADX) rats indicates a strong cell-nuclear localization of …
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Change in the Number of Fibers and Nuclei in the Rat Soleus Muscle During Normal Development and Increased Work Load Exercise
… to demonstrate in animals that skeletal muscle cells and corresponding deoxyribonucleic acid (DNA) increased with exercise, clinical studies on the upper lip would be in order.</p> <p>Male Sprague Dawley albino rats were used to study the effects of exercise and normal development. Increased …
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A cell level automated approach for quantifying antibody staining in immunohistochemistry images. A structural approach for quantifying antibody staining in colonic cancer spheroid images by integrating image processing and machine learning towards the implementation of computer aided scoring of cancer markers.
… quantification of antibody inside stained cell nuclei in immunohistochemistry images is proposed and demonstrated in this research. The system is based on a cellular level approach, where each nucleus is individually analyzed to observe the effects of protein antibodies inside the nuclei. …
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Reversible Germline Dynamics of Caenorhabditis elegans During Exposure to Pathogenic Bacteria
… reduction in gonad size and the number of nuclei in the germline. I define two processes that are induced that contribute to the decrease in the number of germ cell nuclei. First, I observe that infection with P. aeruginosa leads to the induction of programmed germ cell death. Second, I …
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Biochemical and structural studies of histone and associated proteins from chick and human nuclei
… during the interphases and S phase of the cell cycle. It is found inside cell nuclei in eukaryotic cells. There are many important proteins in the nuclei which are involved in DNA replication, gene expression, DNA repair, etc. Core histones, linker histones and HMGs are the most important …
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Submicron-resolution Photoacoustic Microscopy of Endogenous Light-absorbing Biomolecules
… imaging of blood vasculature and red blood cells in vivo. Any molecules which absorb sufficient light at certain wavelengths can potentially be imaged by PAM. Compared with pure optical imaging, which typically targets fluorescent markers, label-free PAM avoids the major concerns that the …
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Early diagnosis of cancer using light scattering spectroscopy
… component of light scattered by epithelial cells to obtain information about subcellular structures, such as cell nuclei. Since nuclear atypia is one of the hallmarks of precancerous and cancerous changes in most human tissues, the technique has the potential to provide a broadly applicable …
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CellVisualizer : exploring hierarchical, multi-dimensional data with applications to high-throughput microscopy
… by high-throughput microscopy and processed by CellProfiler, an open-source system jointly developed by researchers at MIT CSAIL and the White-head Institute. A typical high-throughput microscopy experiment produces thousands of images, with thousands of objects in each image. CellProfiler then …
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Temporal changes in unisexual and sexual Ambystoma salamander populations in southeast Michigan
… Michigan’s E. S. George Reserve using epidermal cell nuclei measurements and microsatellite loci. I found that population composition has shifted away from the more northern-distributed <em>A. laterale</em> and toward populations dominated by unisexuals in five out of six ponds. There was a …
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Deep Learning-Based Comprehensive Pathology Image Analysis
… based HD-Staining models were used to identify cell nuclei of different tissue layers in oral epithelium, and novel Onion Peeling algorithm was developed to count the cell layer numbers. Overall, the deep learning tools in this dissertation serve as aids to pathology evaluation process and can …
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Volumetric Optical Imaging of Tissue Microstructure for Grading of Dysplasia In Vivo
… increases in sizes and densities of epithelial nuclei with the progression of esophageal dysplasia. In this thesis research, we investigate the application of novel signal processing methods and custom OCT hardware to uncover biomarkers of dysplasia based on these pathological changes in cell …
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Motor neurone and muscle nuclear changes in development and disease
… study of the developing anterior horn cell nucleus during fetal life was undertaken. The result suggested that the 12th to 14th week period is critical for the differentiation of the spinal motor neurone. 2. In contrast to this, a similar study of the deve¬ loping muscle cell nuclei …
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Unexpected mechanical properties of nucleic acids
Mechanical deformations of nucleic acids (NA) play a very important role in many biological life processes. The bending persistence length of DNA is of specific interest, because so much eukaryotic DNA that stores genetic information is tightly packed inside cell nuclei, even though DNA is …
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Ehrlichia chaffeensis Type 1 Secreted Effector TRP47 is a Novel SUMOylated Nucleomodulin
… immunoprotective protein effectors into the host cell using a type I secretion system. The best-characterized of these effectors are the tandem repeat proteins (TRPs). In this study, E. chaffeensis TRP47 was identified as a target for host cell SUMOylation and as a novel nucleomodulin with …
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Approaching the Three-Dimensional Organization of the Human Genome
… and three-dimensional organization of the human cell nucleus, the structural-, scaling- and dynamic properties of interphase chromosomes and cell nuclei were simulated on the 30 nm chromatin fiber level with Monte Carlo, Brownian Dynamics and parallel computing methods. Differences between used …
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