Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 249 for “"cell model"”.
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Metabifurcation analysis of a phenomenological ventricular cell model
… Karma(1998)[10] came up with the Fenton-Karma model (the F-K model) with three variables and 13 parameters that is a relatively simple and basic model that including information on alternans. Our research is based on the F-K model at the cell level rather than the tissue level. We study the …
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Cell model of DJ-1-associated Parkinson’s Disease
… is the creation of biologically relevant cell models of PD. The goal of this work was to design a representative cell model of DJ-1-associated PD in order to further study DJ-1 with the intention of elucidating its relevant function in relation of PD pathogenesis.
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Mitochondrial dysfunction in a cell model of thyroid oncocytoma
… A peculiar characteristic of thyroid oncocytic cells is the presence of an abnormally large number of mitochondria in the cytoplasm. Such mitochondrial hyperplasia has also been observed in cells derived from patients suffering from mitochondrial encephalomyopathies, where mutations in the …
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Microphysical-dynamical processes and interactions in a precipitating cumulus cell model.
Thesis. 1977. Sc.D.--Massachusetts Institute of Technology. Dept. of Meteorology.
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Quantified phenotype analysis in a cell model for Autosomal Dominant Retinitis Pigmentosa
Modern cell biology relies greatly on microscopy to assess distribution and dynamics of fluorescently labelled cellular proteins. Quantified image analysis allows not only measurement of clear differences between individual phenotypes and time points, but also discovery of subtle changes which are …
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Modified alginates as a matrix for gene transfection in a HeLa cell model
… 'therapeutic' genetic material into the cell. These approaches have the distinct advantage over viral vectors in being relatively non-immunogenic and noninfective. Though the efficiency of this procedure is poor compared to viruses, developing an effective and safe delivery system is a …
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Cell model of a fluid with hard-core repulsive long-range attractive potential
"A model of a one-dimensional fluid is investigated in which the praticles [sic] are embedded in a cellular space grid and interact with a modified Lennart-Jones potential. It is shown that with an appropriate change in the potential function the model is also suitable for a two- or …
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Effects of CXCL8 Overexpression on Tumor Cell Proliferation and Migration in an HNSCC Cell Model
Head and neck squamous cell carcinoma is the 6th most common malignancyworldwide. Recently, a link between cancer and inflammation has been found. Mediatingthis relationship are the chemotactic cytokines known as chemokines. CXCL8 (Interleukin-8), a CXC ELR+ Chemokine mainly responsible for …
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Investigation of a SPH-based sub-cell homogenization for PHWR using a multi-cell model
… computer codes. Previous work found that single-cell SPH applied to Pressurized Heavy Water Reactors (PHWR) yields virtually no improvement compared to single-cell standard homogenization. This work attempts to improve those results by accounting for neutron leakage across cell boundaries by …
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Ice Recrystallization Inhibition as a Mechanism for Reducing Cryopreservation Injury in a Hematopoietic Stem Cell Model
… applications, such as hematopoeitic stem cell transplantation and sperm banking, sometimes require the use of cryopreserved cells. Cryopreservation, however, can induce cell injury and reduce the yields of viable functional cells. Ice recrystallization is a mechanism of cryopreservation …
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Numerical simulation of bubble columns by integration of bubble cell model into the population balance framework
… wide application can be attributed to the excellent rates of heat and mass transfer that are achieved between the dispersed and continuous phases in such reactors. Although these types of contactors possess the properties that make them attractive for many applications, there still remain …
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Development of a SCA7 patient-derived lymphoblast cell model for testing RNAi knock-down of the disease-causing gene
… this approach has been tested in an artificial cellbased model of SCA7, focus has shifted towards testing the therapy in SCA7 patient-derived transformed lymphoblast cell lines
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The effects of periodic and non-periodic inputs on the dynamics of a medial entorhinal cortex layer II stellate cell model
… that medial entorhinal cortex layer II stellate cells (SCs) exhibit sub-threshold and firing frequency resonance in the theta frequency band (4 - 10 Hz). In this thesis we seek to understand the biophysical and dynamic mechanism underlying these phenomena and how they are related. We studied the …
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ESTABLISHING PTERIDINE METABOLISM IN A BREAST CANCER CELL MODEL AND QUANTIFICATION OF SILVER NANOPARTICLE INTERACTIONS WITH YEAST CELLS USING MASS SPECTROMETRY
… quantitative insights that can be gleaned from cellular analyses, with applications in cancer and nanoparticle research. In the first part of the research presented, a recently developed HPLC-MS/MS method was advanced to elucidate pteridine metabolism in an isogenic progressive MCF10A breast …
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Building an In-vitro Cell Model to Study Cellular Basis of Maturation Timing: A Proof of 3D Cell Culture Methodology in Atlantic Salmon Adipose Tissue
Three-dimensional (3D) cellular cultures have been shown to represent tissue formations and functions more accurately than two-dimensional (2D) cultures and have been successfully utilized more accurately in model organisms, e.g., to understand cellular modular functions. However, the applications …
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Study of apoptotic deletion mediated by Bifidobacterium longum with construction of recombinant strains for Serpin encoding gene and phenotypes comparison in a pig cell model
… to induce apoptosis in “damaged” intestinal cells. Adhesion and apoptosis are the two process that we want to study to better understand the role of an adhesion protein that we have previously identified and that have top scores homologies with the recent serpin encoding gene identified in B. …
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