Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 109 for “"cell metabolism"”.
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Ionic Mechanism of Lysosomal Function and Cell Metabolism
… to impair vesicle trafficking, autophagy and cell metabolism control; however, the detailed mechanism remains largely unknown. In this study, I show that TPCs are critical for appropriate cargo delivery to the lysosomes and deletion of either TPC1 or TPC2 leads to delayed clearance of …
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ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM
… proliferative and migratory activities in cancer cells. Strong evidence suggests that LPA production and expression of its receptors are dysregulated in multiple human malignancies. The mechanism behind LPA-mediated tumor cell growth and oncogenesis remains poorly understood. In this thesis …
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The effects of culture conditions on cell metabolism and function
… profoundly affects the capacity of cell culture to model physiological and pathophysiological states. Central to the modern optimisation of cell culture is the development of physiologic media, which highlight the major impact that specific nutrients can have on a variety of cellular …
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Targeting Unique Domains of Lsd1 Regulates Pediatric Glioma Innate Immunity and Nk Cell Metabolism
… of chromatin accessibility is a key mechanism of cellular identity, allowing different tissues to develop using the same DNA template. Cancers will often hijack these epigenetic pathways, reactivating developmental genes to drive growth and deactivating tumor suppressor and immune recognition …
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Investigating the effects of Wnt/β-catenin Signalling on Melanoma Cell Metabolism and Mitochondrial Dynamics
… pivotal roles in embryonic development, stem cell biology and a number of disease states including cancer. Most Wnts signal through a pathway that results in the stabilisation of an intracellular signalling molecule called β-catenin. In melanoma cells, Wnt/β-catenin signalling has been …
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Characterization of shear stiffness and cell metabolism in chondrocyte-sealed self-assembling peptide hydrogel scaffolds
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2003.
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Mitochondria, Inflammation, and T-Cell Metabolism in a Rat Model of Pediatric Mild Traumatic Brain Injury
… of mitochondrial function, inflammation, and T-cell metabolism. First, we documented females having greater mitochondrial oxygen consumption in brain cells 21 days after a single mTBI, offering insight into one mechanism for persistent impairments in females following pediatric mTBI. Second, we …
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Computational methods for multi-omic models of cell metabolism and their importance for theoretical computer science
… abstraction tools for metabolic networks. Cell metabolism is the set of chemical reactions taking place in a cell, with the aim of maintaining the living state of the cell. Due to the intrinsic complexity of metabolic networks, predicting the phenotypic traits resulting from a given …
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Testing the reliability and selectivity of different bone-cell-specific Cre- expressing mouse models for studying bone cell metabolism
… focuses on the reliability of different bone cell specific Cre models in the Cre/loxP system. In this study, DMP1-Cre transgenic mouse which has a transgene driven by DMP1 promotor that allows Cre-expression only in late stage osteoblasts and osteocytes was used. Ctsk-Cre mouse with a driven …
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The Physiological Effects of CD38 in Prostate Cancer: A multifunctional NAD'ase capable of regulating cell metabolism, gene expression, and therapeutic response
Deregulation of cellular metabolism is a critical step during oncogenesis. Tumor cells rely heavily on changes to cell metabolism to support increased macromolecule biosynthesis, sustain membrane biogenesis, and cell survival. Nicotinamide adenine dinucleotide (NAD+) is linked all aspects of cell …
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Broad Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β-cell Metabolism in the Absence of Dietary Overnutrition
… protein deacetylase purported to influence cellular and systemic metabolism through modulation of the mitochondrial acetylproteome. Fuel-stimulated insulin secretion from pancreatic islets involves mitochondrial metabolism and might be susceptible to SIRT3-mediated effects. To investigate …
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Metabolic Mechanisms of Nutritionally Regulated Hormone Signaling on T Helper Cell Function
… hormones communicate nutritional status to cells and tissues throughout the body. In the case of overnutrition or obesity, levels of leptin, insulin, and insulin like growth factor 1 (IGF-1) are increased, whereas they are decreased in the setting of undernutrition. Either undernutrition or …
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The Role of Metabolism and Epigenetics in Regulating Cellular Plasticity
Eukaryotic cells encode genetic information in the form of DNA. However within our genetic code, only a subset of these genes are expressed in a given cell—giving rise to different cell types. The regulation of what genes are expressed is dictated by epigenetics. Epigenetics is the punctuation of …
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EXPLORING THE ALLOSTERIC INHIBITION MECHANISM OF HUMAN KIDNEY TYPE GLUTAMINASE TO ARREST CANCER CELL PROLIFERATION AND INVESTIGATING HAKAI MEDIATED UBIQUITINATION TOWARDS CONTROLLING CANCER CELL MIGRATION
… hallmarks. Two among them are the altered cell metabolism (Warburg effect), and cancer cell invasion/progression mediated by post-translational modulation of cell signaling. In this thesis we have attempted to explore these two hallmarks towards understanding different avenues to arrest …
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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
Cancer cells display oncogene-driven rewiring of metabolism to produce energy and macromolecules for growth. Inhibition of growth-promoting metabolic pathways may prove to be a useful therapeutic strategy in cancer. However, neither the full breadth of cancer cell metabolic diversity, nor the …
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Mycoplasma Pneumoniae Infections - Role of Nucleotide Metabolism in the Mechanism of Pathogenesis
… induces a cytopathic effect (CPE) in host cells is not clearly defined. This study was designed to delineate some of the factors involved in the mechanism of pathogenesis of M. pneumoniae infection. Two major areas affecting the host-parasite interaction were studied. These included the …
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Metabolism of Two Model Xenobiotics in Cultured Plant Cells
Plant cells in culture were found to oxygenate two model xenobiotics. Para-chlorophenyl methyl sulfide was S-oxidized by carrot, cotton, tobacco, alfalfa, and blacknightshade cell cultures. The rates of S-oxygenation by cultured plant cells were comparable to the rates in animal tissue …
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