Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"cell membrane integrity"”.
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AN INVESTIGATION OP POSSIBLE IN VITRO METHODS FOR STUDYING EYE IRRITANCY POTENTIAL
… procedures, namely the measurement of cell membrane integrity using fluorescein diacetate and ethidium bromide, and the quantitation of the release and activity of a cell membrane-bound enzyme, alkaline phospha1ase,were used to assess the qytotoxicity of a range of cationic, anionic and …
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The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease
… of protein synthesis and disruption of cell membrane integrity. Principal use is in treatment of Gram negative infection although aminoglycosides have activity against some Gram positive organisms including staphylococci. Aminoglycosides are inactive against anaerobes. Acquired …
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Effect of cinnamon oil nano-emulsion to control the foodborne bacteria Salmonella spp. on mung beans and sprouts
… efficacy of cinnamon oil nanoemulsion. Cell-membrane integrity has been performed to confirm the results of MIC and MBC. The minimum inhibitory concentration (MIC) of cinnamon oil nanoemulsion for salmonella was 0.03125%. The minimum bactericidal concentration was MIC i.e., 0.3125%. …
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Characterization of C. Elegans Pat-9 and Frg-1, Genes Critical for Body Wall Muscle Development
… by attaching the muscle fiber to the muscle cell membrane and the surrounding extracellular matrix (ECM). Thus, dense bodies are functionally similar to the vertebrate Z-disk and contain homologs of many of the same Z-disk proteins. Many other types of muscular dystrophy, such as Duchenne, …
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Functional Imaging to enable more accurate localisation and characterisation of prostate tumours
… MRI can offer functional information reflecting cell membrane integrity and cell viability. Chapter 5 evaluates whether the PET/CT tracer 11C-acetate can offer additive information on primary prostate tumours. Tristan Barrett
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St John's Wort photomedicine for Melonoma
… light and molecular oxygen. Following cellular uptake of the photosensitizer, its activation by light produces reactive oxygen species in the presence of oxygen. The resulting cytotoxic oxidative stress elicits cancer cell death by various mechanisms including apoptosis, necrosis and …
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Novel polyamine based anticancer agents: evaluation of the mode of action.
… in colon, breast and leukaemia cancer cell lines. The most active compound, BNIPSpd exhibits 24-hour IC50 values ranging from 0.47-2.40 mu M in Caco-2 and HT29 colon cancer cells and MCF7 breast cancer cells. Onset of action of these novel compounds is faster than similar compounds, …
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Modulation of bovine preimplantation embryonic development and pregnancy by FGF2, LIF, and IGF1
… first recognized for its role in embryonic stem cell derivation and then for improvements to in vitro porcine embryo production. These same three cytokines have been identified as embryokines in the cow and have the potential to improve in vitro bovine embryo production. Thus, the central goal of …
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Factors regulating the production of STX-2 in Escherichia coli O157:H7
… of stx2 and those antibiotics that disrupt cell membrane integrity. However, these antibiotics did not increase the overall levels of Stx-2 released from E. coli O157:H7. The probiotic microorganisms Lactobacillus casei and L. plantarum were found to decrease both stx2 expression and Stx-2 …
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Characterization of C. elegans PAT-9 and FRG-1, which are critical for body wall muscle development
… biological processes including apoptosis, the cell cycle, gene regulation, cell polarity, metabolism, aging, and development. Transgenic C. elegans have been broadly utilized as a human disease model to study mechanisms of pathology for diseases such as obesity, diabetes, cancer, Duchenne’s …
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Investigating the physiological and metabolomic effects of Ecklonia maxima-derived biostimulant foliar application in ameliorating the effects of heat shock in tomato plants
… to physical damage, structural damage to plant cell walls and membranes and the overproduction of reactive oxygen species (ROS) also cause metabolic and cellular disturbances. Concurrently, there has been a growing demand for sustainable and affordable agricultural practices using eco-friendly …
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Dissecting the molecular responses of Sorghum bicolor to Macrophomina phaseolina infection
… (ROS) and nitrogen species (RNS)-mediated host cell death. The paradoxical hormonal regulation observed in pathogen-inoculated Tx7000 was characterized by strongly upregulated salicylic acid and down-regulated jasmonic acid pathways. These findings provided useful insights into induced host …
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Nitric oxide and peroxynitrite-induced cellular damage
… it the potential to cause considerable damage to cells and tissues in its vicinity. Although excess production of NO' can lead to damage and toxicity, the precise mechanisms underlying NO'⁻induced cellular toxicity are still very unclear. One of the objectives of this study was to analyze in …
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Magnetic resonance spectroscopy quality assessment at CUBIC and application to the study of the cerebellar deep nuclei in children with fetal alcohol spectrum disorder
… deficient calcium signalling or decreased cell membrane integrity ' both of which can explain the compromised cerebellar learning in FASD subjects.
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Characterisation and Screening of secondary metabolites from Commiphora viminea (Burtt Davy, Burseraceae) Engl. for antifungal properties against Candida auris
… to the antifungal activity by disrupting fungal cell membrane integrity and inhibiting essential enzymes. The water extracts exhibited weaker antifungal effects, likely due to the poor membrane permeability of highly polar compounds. The findings align with reports that Commiphora species possess …