Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"cell mediated immunity"”.
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Humoral and cell-mediated immunity in vitamin A-deficient lambs
Antigen-specific and polyclonal serum immunoglobulin G (IgG) concentrations were measured in control (Con), vitamin A-deficient (A-def), and vitamin A-repleted (A-rep) lambs. In Trial, I ewe lambs were injected with primary and secondary antigenic challenges of ovalbumin (1mg) and lysozyme (.1mg). …
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Splenic Regulation Of Cell Mediated Immunity To Listeria Monocytogenes: Suppression Of Macrophages
… investigated. To determine if suppression was cellular or humoral, splenectomized mice were reconstituted with normal syngeneic spleen cells and normal plasma from Listeria-stimulated normal donors. Mice receiving spleen cells showed no decreased resistance by mice receiving plasma showed …
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Model systems for the retargeting of T cell-mediated immunity to tumor antigens
B cells and T cells are involved in the response against foreign antigens. Specificity of B cells is determined by antibodies while the specificity of T cells is determined by similar proteins called T-cell receptors. One function of T cells is surveillance against tumor cells. Progressing tumors …
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The potential role of interleukin-2 in impaired cell-mediated immunity of iron deficiency
Iron deficiency impairs cell-mediated immunity, which is primarily dependent on T-lymphocyte functions including production of the cytokine, interleukin 2 (IL-2). The potential role of IL-2 production and responsiveness in impaired cell-mediated immunity of iron deficiency was investigated in a …
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The role of cell-mediated immunity during coronavirus infections in cats : opportunities for therapeutic avenues?
… De focus werd daarom geplaatst op NK cellen, T lymfocyten en regulatorische T cellen (Tregs), die elk cruciaal zijn in respectievelijk de adaptieve, aangeboren en regulatorische immuunresponsen.
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Cell-mediated immunity in Marek's disease virus-infected chickens genetically selected for high and low levels of plasma corticosterone
… stress, HPC chickens demonstrated a decreased cell-mediated cytotoxicity (CMC) in comparison with LPC chickens. In both steroid lines, CMC decreased with the onset and severity of tumors. The impaired CMI seen in the HPC line corresponded with an increased tumor incidence and a greater …
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Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells
<p>Conventional dendritic cells (cDCs) are an essential immune population, responsible for controlling adaptive immunity and tolerance. Recently, type I cDCs (cDC1s) have been delineated as a distinct cDC subset, uniquely responsible for coordinating T cell-mediated immunity against pathogens and …
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Analysis of Porcine Immunity in PRRS Virus
… the immune response to PRRSV with emphasis on cell-mediated immunity. Analysis of immune responses amongst pigs following either inoculation with virulent or attenuated PRRSV indicated that this immunity was weak and protracted. These results were confirmed in additional experiments designed to …
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Immunological and hematological biomarkers for contaminants in fish-eating birds of the Great Lakes
… antibody production and alters white blood cell (WBC) counts. This study investigated whether persistent contaminants alter immunocompetence in Great Lakes herring gulls (Larus argentatus) and Caspian terns (Sterna caspia). It also evaluated the use of various immunological tests as …
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REGULATION OF T CELLS AND TISSUE INFLAMMATION BY SHORT CHAIN FATTY ACIDS
… investigated the roles of SCFAs in regulating T cell differentiation and tissue inflammation. We found that SCFAs regulate T cell differentiation and T cell-mediated immunity. SCFAs enhanced both IL-10+ T cell and Th1/Th17 effector T cell differentiation. SCFAs inhibited histone deacetylase …
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Effects of heat stress and fescue toxicosis on the immune system and other physiological parameters
… was less severe with adaptation. However, cell mediated immunity was compromised, which makes animals susceptible to invading pathogens. This research identified adaptive responses to fescue toxicosis that highlighted shifts in immune function.
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Studies on the Possible Regulatory Function of Dietary Alpha-Linolenic Acid in Prostaglandin Synthesis by Immunocompetent Cells
… fatty acid (EFA), and therefore of PGs, in cell-mediated immunity has increasingly become of interest. Prostaglandins have been implicated in many areas of the immune response. Three studies were conducted examining both in vivo and in vitro rat immune models to study the regulatory …
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Transcriptional Regulation of the Inducible Costimulator (ICOS) in T Cells
… molecules and plays a central role in T-cell-mediated immunity. In this study, we investigated the molecular regulation of ICOS expression during early activation of CD4+ T cells by T cell receptor and CD28 co-engagement as well as during the differentiation of these cells into Th1 and …
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A Study on the Effectiveness of Activated Murine Peritoneal Macrophages in Killing Candida Albicans Hyphae
… organism to evade normal host defenses. Since cell-mediated immunity plays a vital role in resistance to candidosis, macrophages, phagocytic cells of the immune system, are particularly important in elimination of Candida. When activated, macrophages exhibit increased candidaciadal activity. …
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The Effect of Dietary Fat Level on Tumor Development and Immunity in BALB/C Mice Fed Casein of Wheat Gluten as Protein and Challenged with Herpes Type 2-transformed Cells
… with herpes simplex Type 2-transformed mouse cells (H238), the effects of a diet which greatly enhanced tumor growth was compared with one which restricted tumor growth. The latter, a low (5%) fat, low protein diet, in which the protein was casein, was also found to produce a higher cell …
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The use of whole blood cell cultures as a model for assessing the effects of SeptilinTM on the immune system.
… and IFN? as biomarkers for inflammation, humoral immunity, and cell mediated immunity, respectively. Results show that the presence of SeptilinTM in LPS stimulated WBC has no effect on the release of IL-6 and IFN? production but stimulated IL-10 production. SeptilinTM in unstimulated WBC has no …
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The immune-modulating activity of Sutherlandia frutescens
… frutescens on the inflammatory response and T cell differentiation in vitro using cytokines as biomarkers. Whole blood cells containing various concentrations of Sutherlandia frutescens were stimulated in vitro with either Lipopolysaccharide (LPS) or Phytohaemagglutinin (PHA). Results show that …
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Protective Immunity in Mice Immunized with the Nfa1 Protein for Pathogenic Naegleria fowleri Infection
… In the present study, to examine the protective immunity of the Nfa1 protein for N. fowleri infection in a mouse model, BALB/c mice were immunized with the Nfa1 protein either by intraperitoneal or intranasal route, and then infected intranasally with N. fowleri trophozoites. In regardless of the …
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CROSS-REACTIVITY BETWEEN MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN AND ROUS SARCOMA VIRUS-INDUCED TUMOR ANTIGEN IN CHICKENS
… of either viable or lysed white blood cells (WBC) or viable red blood cells (REC) from B5B5 chickens had a significantly higher incidence of tumor progression than untreated, phosphate buffered saline treated, or B2B2 WBC inoculated B2B2 chickens. The criteria of tolerance were absence …
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Toxic effects of dietary methylmercury on immune system structure, function, and development in the American kestrel (Falco sparverius)
… kestrels. Immunological endpoints included cell-mediated immunity (CMI) using the phytohemagglutinin (PHA) skin-swelling assay and antibody-mediated immune function using the sheep red blood cell (SRBC) hemagglutination assay. Hematology profiles were evaluated over time in adult males and …
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