Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"cell mechanical properties"”.
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Microfluidic devices for analysis of red blood cell mechanical properties
Decreased deformability of human red blood cells (RBCs) is both a cause of disease and biomarker for disease (1). To traverse blood capillaries, the biconcave disk-shaped RBC must deform dramatically, since the diameter of the unconstrained RBC is larger than that of the capillaries. If the RBC …
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Quantitative correlations among human mesenchymal stem cell mechanical properties and biological function
Mesenchymal stem cells (MSCs) are derived from bone marrow, and are capable of proliferating and differentiating along multiple pathways such as osteoblasts, chondrocytes and adipocytes. MSCs offer the means for regenerative therapies not possible with conventional small molecule/antibody/ nucleic …
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Breast Cancer Cell Mechanical Properties and Migration on Collagen I Matrices with Tunable Elasticity
Unlike their normal counterparts, breast cancer cells break free from epithelia and invade the underlying stroma, leading to deadly metastases. Cell migration requires mechanical interactions between the intracellular cytoskeleton and the extracellular matrix. The goals of this work were to compare …
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Developmental Alterations in the Distribution of Specific Lateral Wall Proteins Modify Outer Hair Cell Mechanical Properties
In the mammalian cochlea, specialized outer hair cells (OHCs) housed within the organ of Corti exhibit nonlinear, mechanical responses to auditory stimulation [1]. These electromotile responses increase hearing sensitivity 100-fold (40 dB) and are responsible for frequency selectivity in the …
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Technology assessment and feasibility study of high-throughput single cell force spectroscopy
In the last decade, the field of single cell mechanics has emerged with the development of high resolution experimental and computational methods, providing significant amount of information about individual cells instead of the averaged characteristics provided by classical assays from large …
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Hydrodynamic resistance and sorting of deformable particles in microfluidic circuits
… applications in science and technology, from cell analysis to sample purification for biomaterials, photonics, and drug delivery. Methods used for particle separation relied only on procedures that involved sedimentation, filtration through porous material or other physical procedures that …
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On the theory of the optical stretcher : optics, mechanics, and thermal effects
… deforming micron-sized particles or biological cells. It can be employed to measure cell-mechanical properties and, thus, to monitor physiological changes, such as differentiation, and to diagnose diseases that affect the structural integrity of cells, like cancer and sickle-cell anemia. To …
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Application of a Novel Quasi-3D Microscopy Technique to Investigate Early Osteocyte Mechanotransduction Events
… thesis is to observe and characterize the early mechanical and biochemical events in osteocyte mechanotransduction. Physical forces have been increasingly implicated in normal physiological and pathological cellular activities of osteocytes. The mechanotransduction process in osteocytes involves …
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Combining optical and hydrodynamic forces for single cell characterization, isolation and delivery
With the existence and emerging importance of cellular heterogeneity there has been a push in the microbiology community for new tools to study at the individual cells. To meet the need to identify, characterize and isolate single cells of interest from bulk samples, precise and directed forces on …
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Dynamical models, chemo-mechanical coupling and numerical recipes for some soft biological systems
Living cells actively sense and respond to a vast variety of biochemical and mechanical signals whose strong interplay regulates most of cellular physical properties. Advances in the field of mechanobiology suggest that changes in cell mechanics, ECM structure, or molecular mechanisms by which …