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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 121 for “"cell mass"”.
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Defining the contributors to mammalian cell mass
… many biosynthetic processes. To proliferate, a cell must not only physically divide but must also newly synthesize each of its components as it progresses through the cell cycle. Metabolism allows a cell to meet these demands. Metabolic alterations associated with proliferating cells have been …
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Method for single-cell mass and electrophoretic mobility measurement
Analysis of single cells using flow cytometry techniques has created a wealth of knowledge about cellular phenomena that could not be obtained by population average measurements. As these techniques are integrated with others to increase the number of parameters that can be measured on single cells …
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Muscle Strength and Body Cell Mass in Postmenopausal Women
… associated with a decline in muscle strength and mass. It has also been observed that total body potassium and intracellular water (ICW) decrease with age, reflecting a loss of body cell mass (BCM), 60% of which is the skeletal muscle. It is generally accepted that traditional high-intensity …
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Single-cell mass measurements for drug susceptibility testing in cancer
… resonator (SMR) is a sensor that measures the mass of individual micron-scale particles by detecting a shift in resonance frequency as particles flow through a hollow resonating micro-cantilever beam. While SMRs offer extreme precision for measuring mass, their applications have been limited by …
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Molecular Thermodynamics and Knudsen Cell - Mass Spectrometer Studies of Liquid Metal Mixtures
Made available in DSpace on 2014-12-13T18:55:34Z (GMT). No. of bitstreams: 1 7709140.pdf: 5295489 bytes, checksum: 35b97660db8ded30f6f94b9965342212 (MD5) Previous issue date: 1976
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DEVELOPMENT OF SINGLE-CELL MASS SPECTROMETRY TOOLS TO INVESTIGATE METABOLIC REORGANIZATION DURING EARLY EMBRYOGENESIS
Measurement of metabolism in single cells holds the potential to advance our understanding of fundamental biological processes during cell differentiation and development. However, to characterize the metabolic state of single cells, further technological advances are still required. This …
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Development of high-Q micromechanical cell mass sensor (optimizing parameters for in-plane mass sensors)
… a strong correlation between the behavior of a cell, its physical properties, and its surrounding environment. Biomechanics has led to an improved understanding of the way diseases evolve and their progression cycle, providing methods targeted towards curing these diseases. Moreover, many …
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The Role of Amino Acids and the Threonine-SAM Pathway in the Development of Bovine Inner Cell Mass and Pluripotency
Pluripotent stem cells (PSCs) are the foundation of all cell types in the body including functional gametes. They are derived either from the inner cell mass (ICM) of preimplantation mouse and rat embryos, known as embryonic pluripotent stem cells (ePSCs) or embryonic stem cells (ESCs) or via …
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Ranolazine: a Potential Anti-diabetic Drug
… 24 million Americans. Loss of pancreatic beta-cell mass and function is central to the development of both type 1 (T1D) and type 2 diabetes (T2D). Therefore, preservation or regeneration of functional beta-cell mass is one of the essential strategies to treat diabetes [1]. In my study, I tested …
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Proteomic Characterization of Human Multipotent Stromal Cells Secreted Proteins with Therapeutic Potential for β-cell Regeneration
Novel strategies to stimulate the expansion of β-cell mass in situ are warranted for diabetes therapy. Cell-replacement therapies for the treatment of diabetes have become a focal point in recent years. Endogenous regeneration of β-cell mass has been demonstrated using human multipotent stromal …
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Stress-inducible Mig6 promotes pancreatic beta cell destruction in the pathogenesis of diabetes
Pancreatic insulin-secreting beta cell failure is central to the development of diabetes. Therapeutic applications targeted at understanding and manipulating beta cell destruction mechanisms should enhance the preservation of functional beta cell mass and prevent diabetes. To this end, we have …
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Using resonant MEMS pedestal sensors and filtering techniques to determine the growth curve of MDA-MB-231, metastatic breast cancer cells
Studying cells at the individual level is incredibly important for understanding underlying mechanisms for growth, cell cycle control, cell mass, cell adhesion to surfaces, and ultimately the nature of cancer cells. A resonant pedestal sensor was used to study single, adherent cells non-invasively. …
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Mathematical analysis of fractional-order chemostat model with time delay
… there will be some change in amount of the cell mass concentration whether increase or decrease when the system is unstable, so chemostat system can be well controlled in order to be suitable for cell mass production. Other than that, the convergence speed of nearby trajectories increased …
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Utilization of a Microbubble Dispersion to Increase Oxygen Transfer in Pilot-Scale Baker's Yeast Fermentation Unit
… the MBD method considerably improved the cell mass yield, growth rate and power consumption in the 50-liter fermentor. Cell mass production in the MBD system at agitation rate of 150 rpm was about the same as those obtained for a conventional air-sparged system agitatid at 500 rpm. Power …
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The non-canonical NF-kappaB pathway as a novel player in beta cell dysfunction in diabetes
Loss of pancreatic β cell mass and function is a feature of both type-1 and type-2 diabetes. The non-canonical NF-κB pathway has recently garnered attention at being involved in the development of peripheral insulin resistance (liver, muscle) in diabetes. Whether pancreatic β cell non-canonical …
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Evaluation of resting energy expenditure in sarcoma patients with localized disease
… body potassium (40K) as an indicator of body cell mass. and calculation of body surface area. Resting energy expenditure was measured by indirect calorimetry in an enclosed plexiglass hood and compared to predicted resting energy expenditure as determined by the Harris and Benedict formulae. …
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Overproduction of xylose isomerase in recombinant Escherichia coli
… were compared, based on parameters of cell metabolism and inducible enzyme activity in shake flask cultures. E. coli strain LE392 (pRK248/pTXI-l) performed the best with respect to nearly all of the parameters tested. The stability of the overproducing plasmids was tested in prolonged …
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Detection of mass, growth rate, and stiffness of single breast cancer cells using micromechanical sensors
… stems from a number of different mutations in a cell. These mutations often control the cellular growth and proliferation, a hallmark of cancer, and give rise to many altered biophysical properties. There exists a complex relationship between the behavior of a cell, its physical properties, and …
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