Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"cell lineage tracing"”.
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Single-Cell Lineage Tracing Of Cancer Metastasis
… macsGESTALT, an inducible CRISPR-Cas9-based lineage recorder with highly efficient single-cell capture of both transcriptional and phylogenetic information. Applying macsGESTALT to a mouse model of metastatic pancreatic cancer, we recover ~380,000 CRISPR target sites and reconstruct …
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Development and Evolution of the Skull-Neck Boundary: Insights from Amphibian Model Species
… the occiput, in A. mexicanum and X. laevis using cell-lineage tracing techniques to track somitic contributions to the skull, hypoglossal nerve complex morphological data, and traditional whole-mount cartilage and bone staining techniques. Finally, I perturbed Hox gene expression patterns to …
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The Regulatory Mechanism of Dietary Pattern in TMJ Condyle Growth
… of chondrocyte transdifferentiation into bone cells during postnatal condylar growth is unknown. Purpose: To quantify the effects of dietary loading on condylar chondrocyte transdifferentiation. Research Design: Chondrocyte tracing was performed in 21 Aggrecan-Cre;R26Tomato;2.3Col1a1-GFP mice. …
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DEVELOPMENT OF SINGLE-CELL MASS SPECTROMETRY TOOLS TO INVESTIGATE METABOLIC REORGANIZATION DURING EARLY EMBRYOGENESIS
Measurement of metabolism in single cells holds the potential to advance our understanding of fundamental biological processes during cell differentiation and development. However, to characterize the metabolic state of single cells, further technological advances are still required. This …
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Axial patterning of the chondrichthyan pharyngeal endoskeleton and the origin of the jaw
… 2nd pharyngeal) arch. I demonstrate here, by cell lineage tracing, that the pseudobranch is, in fact, mandibular arch derived, that it shares gene expression features with developing gills, and that its supporting spiracular cartilage develops under the influence of a shh-expressing signalling …
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MITO: ROBUST INFERENCE OF MITOCHONDRIAL PHYLOGENIES AND CLONES
Somatic evolution, the process by which cells acquire genetic and epigenetic changes throughout an individual’s lifetime, underlies both normal development and diseases like cancer. Single-cell lineage tracing (scLT) has emerged as a powerful approach to study these cellular dynamics, especially in …
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Determine the developmental dynamics of primordial follicles in the mouse ovary
… gradually in later life. The time-lapse tracing study has shown that the first wave of primordial follicles exist in the ovaries for about 3 months and contribute to the onset of puberty and to early fertility, whereas the adult primordial follicles gradually replace the first wave and …