Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"cell labelling"”.
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Development of 89Zirconium-PET Tracers for Immune Cell Imaging
The use of cell-based therapies as a living drug have gained considerable attention for the treatment of a range of conditions such as genetic diseases, autoimmune disorders and cancer. The emergence of genetically engineered T cells expressing chimeric antigen receptors (CAR T-cells), together …
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MODIFIED BODIPY PROBES TO EXPLORE PEROXISOME FUNCTION
… to measure biological function within a plant cell. In particular developing BODIPY fluors with emission at near-infrared and long wavelength that provides considerable benefit for specific organelle monitoring will be explored. The work described in this thesis was mainly focused on the …
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Tracing clonal cell plasticity in the microenvironment of pancreatic ductal adenocarcinoma
The pancreas may regenerate without stem cells by induction of cellular plasticity between differentiated cells. Although essential for the remarkable capacity for pancreas regeneration, this property entails a vulnerability to cancer through acinar-to-ductal metaplasia and dedifferentiation by …
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Shape dependent iron oxide nanoparticles for simultaneous imaging and therapy
… contrast agents. Furthermore, we explored the cellular uptake behaviors of the subnanometer ultrasmall nanoparticles and ultrathin nanowires. The nanoparticles were functionalized with tannic acid and incubated with HepG2 cells. The shape dependent cellular uptake was quantified, and the …
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Synthesis of Cadmium Selenide Quantum Dots and Their Cytotoxicity
… areas through different methods such as cell labelling and drug delivery (Chapter1). This study aims to test the optical and biological properties of CdSe NPs so that its applications can be improved in these areas in the future. Three types of CdSe NPs have been synthesised using a wet …
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Microfluidic Methods for Investigating Cell Migration and Cell Mechanics
… topology of the environment that surrounds the cell. Additionally, I sought to develop a microfluidic device able to measure mechanical properties of single cells with a sufficient throughput to account for the inherent heterogeneity of biological samples. Throughout this thesis I made use of …
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STUDY OF PHYSIO-PATHOLOGICAL MECHANISMS AT THE BASE OF SCHWANNOMA DEVELOPMENT
… consisting of a clonal population of Schwann cells (SCs), which often undergo cystic and degenerative changes. Most cases are sporadic, however, some are associated with neurofibromatosis type 2 (NF2), schwannomatosis (SCH) or the pathology called Carney's complex. The schwannoma affecting the …
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The effect of AAV1/2 mediated delivery of brain-derived neurotrophic factor and fibroblast growth factor-2 on adult rodent neurogenesis
… integrated neurons are generated from progenitor cells. In the adult mammalian brain two sites of high density cell division have been identified that contain neural progenitor cells retaining the ability to generate new neurons: the subgranular zone of the hippocampus (SGZ) and the subventricular …
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IN VIVO IMAGING OF STEM CELL MEDIATED TREATMENT IN A MOUSE MODEL OF SPINAL CORD INJURY
Introduction: The use of adult stem cells in cell-mediated therapies is an area of considerable interest within tissue regeneration research. However, important variables such as the distribution of the injected cells, cell survival, target organ localisation cell proliferation and differentiation …