Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"cell labeling"”.
-
Controlled metabolic cell labeling and bioorthogonal click chemistry for cancer targeting
… of unnatural sugar-mediated controlled metabolic cell labeling and bioorthogonal Click chemistry. By controlling the metabolic glycoengineering processes of unnatural sugars via rational chemistry designs, I was able to design a library of trigger-activatable sugar precursors that can label cell …
-
Technology Development for the Functional and Structural Analysis of the Brain
… brain. In functional studies, methods to study cell dynamics have relied on the use of electrodes or dyes. Genetically encoded indicators have gained popularity because they are non-invasive and targetable. We focus on potassium as it’s proposed its homeostasis in the brain is supported by glia, …
-
Polymer-coated iron oxide nanoparticles for medical imaging
… A FH-based nanoparticle that can be used for cell loading is synthesized by covalently combining Feraheme with protamine, a pharmaceutical that also acts as a membrane translocating agent. A rhodamine-protamine conjugate is synthesized and then covalently bound to amino-FH using carbodiimide …
-
Synthesis, Characterization, and Evaluation of Silica-Nanosphere-Based Contrast Agents for Biomedical Application
… by MPMS indicated that these spheres show excellent magnetization values and high T2 relaxation time for MRI measurements, making them suitable as dual modality contrast agents and further applications for cell-labeling/tracking when they are conjugated with other bio-molecules such as …
-
COMPARISON OF EQUINE BONE MARROW-, UMBILICAL CORD MATRIX-, AMNIOTIC FLUID- AND TENDON-DERIVED PROGENITOR CELLS
Mesenchymal stem cells have been recently investigated for their potential use in regenerative medicine. It has been suggested that there may be a stem cell population within both umbilical cord matrix and amniotic fluid. However, little knowledge exists about the characteristics of these …
-
Convective intracellular macromolecule delivery for cell engineering applications
Efficient intracellular delivery of target macromolecules remains a major obstacle in cell engineering, cell labeling, and other biomedical applications. Current standard methods of intracellular delivery, such as viral transduction and electroporation, do not meet the growing needs in the cell …
-
Bioinspired soft matter self-assembly and its use in biomedical applications
… matter, and many biomedical products, such as 3D cell culture platforms or nanocarriers for drug and imaging agent delivery, often consist mostly of soft matter. Despite advances in these fields, concerns still exist regarding the function, reproducibility, and cost of soft matter systems for …
-
Syntheses of biocompatible luminescent nanocrystals for visible and short-wave infrared imaging applications
… (QY), narrow photoluminescence spectra, and excellent photostability. However, challenges remain to be solved to transfer the as-synthesized hydrophobic QD to aqueous solutions while maintaining the high QY and a compact size. This study involves the design and synthesis of a novel ligand that …
-
Stem cell membrane engineering: an approach for modulating cell-biomaterial interactions
Cell membrane engineering is an emerging approach in the field of tissue engineering which aims to exploit the modification of cell membranes for a variety of applications including cell homing and retention, stem cell-tethered biosensors, and cell-mediated drug delivery. Compared to procedures …
-
hyaluronic acid networks in wound healing
… often involve an abnormal accumulation of extracellular matrix (ECM)–a network of molecules occupying the space outside of cells. Beyond structural support, the ECM plays a crucial role in directing cell behavior through biomechanical and biochemical signals. However, the very process of wound …
-
Development of fluorescent semi-conductor nanocrystal conjugates for in vitro and in vivo imaging applications
… broad absorption, high quantum yield (QY), excellent photostability, and a large two-photon absorption cross section. However, unlike other imaging probes, the surface ligands determine the solubility, stability, quantum yield (QY), biocompatibility, and derivatizability of QDs. Therefore, to …
-
Design and synthesis of biocompatible fluorescent semi-conductor nanocrystals for in-vivo and in-vitro imaging/sensing applications
… QDs that exhibit low non-specific binding to cells, small hydrodynamic diameter (HD), tunable surface charge, high quantum yield, and good solution stability across a wide pH range. These ligands feature dihydrolipoic acid for tight binding to the QD surface, a short poly(ethylene glycol) …
-
Simultaneous Immersion Mirau Interferometry
… no-UV vibration-insensitive imaging of live cells in an epi-illumination geometry. This technique can be implemented in a variety of imaging applications. For example, it can be used for cell targeting as a part of a platform for targeted cell irradiations - single-cell microbeam. The goal of …
-
Development of leg motor neurons in drosophila melanogaster
… and dendritic morphologies by using single cell labeling methods. Each motor neuron that has unique axonal targeting and dendritic architecture is born in a stereotypic birth order from a specific lineage. Leg motor neurons targeting similar muscles share dendritic territory in the CNS and …
-
Next generation multi-color carbon dots: A comprehensive understanding of their photophysical properties and subsequent use for biomedical applications
… strong optical properties, water solubility, excellent biocompatibility, and easy synthetic procedures. These remarkable properties of CDs have resulted in utilizing them for a wide variety of biomedical application ranging from bioimaging, cell labeling, drug delivery, and sensors. For …