Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"cell junctions"”.
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Mechanical regulation of cell-cell junctions
Cadherins are cell-cell adhesion proteins that mediate cell recognition, segregation, and signaling in many tissues. Recent findings demonstrated that type I classical cadherin complexes are mechanosensitive. Mechanical forces in the tissue environment play a profound role in the growth, …
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E-cadherin mechanotransduction beyond cell-cell junctions
… and integrin receptors form crucial extracellular adhesive connections with, respectively, adjacent cells and the extracellular matrix, and transduce mechanical signals across cell membranes. The role of adhesive complexes in diseases, cardiomyopathies, atherosclerosis, cancer, stem cell …
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Flow-induced mechanotransduction in cell-cell junctions of endothelial cells
Endothelial cells show an unexpected behavior shortly after the onset of laminar flow: their crawling speed decreases ~40% within the first 30 min, but only in a confluent monolayer of endothelial cells, not in subconfluent cultures, where cell-cell interactions are limited. This led us to study …
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Regulation of cadherin adhesion at intercellular junctions
Adhesion proteins maintain cell-cell interactions, which are critical for tissue formation and the hierarchical organization of all multicellular organisms, and among them, cadherins are the major transmembrane cell-cell adhesion proteins in all vertebrate tissues. Regulation of cadherin mediated …
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The role of PAK6 in HGF-induced prostate cancer cell migration
Cell migration plays a significant role in carcinoma metastasis in which cancer cells move from the primary site and establish tumours at a secondary location. During tumour progression cancer cells can assume a migratory phenotype which is characterised by cell-cell dissociation and single cells …
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Photonic Tweezers for Optical Manipulation of Cells and Tissues
… on applying optical tweezers for the study of cell-cell junctions in tissues.<br/><br/>Typical values for optical tweezers forces range between tenths to hundreds of pN, with only few examples of tweezers reaching nN forces. I synthesised photonically structured probes and obtained tweezers …
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HUMAN CLCA2 IS A P53-DEPENDENT ZINC METALLOPROTEASE AND ITS INTERACTION WITH EVA1 MAINTAINS DIFFERENTIATION OF HUMAN MAMMARY EPITHELIAL CELLS
… or purified protein from CLCA2-transfected cells, we show here that CLCA2 cleavage is catalyzed by zinc and inhibited by metal chelator EDTA. Moreover, an E165Q mutation in the metal binding site abolished processing without affecting stability or trafficking. The mutant could be cleaved by …
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Tumor cell extravasation in an in vitro microvascular network platform
A deeper understanding of the mechanisms of tumor cell extravasation is essential in creating therapies that target this crucial step in cancer metastasis. Extravasation assays exist, but with limitations; data from in vivo models are frequently inferred from low-resolution end-point assays while …
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VE-cadherin mechanotransduction signaling and its regulation by extracellular matrix
… that regulate the integrity of inter endothelial junctions in response to mechanical perturbations. The vascular endothelium forms a natural barrier between blood and tissues and its disruption leads to blood leakage and serious pathological consequences. VE-cadherin—the primary adhesion molecule …
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The Localization of β-catenin During Xenopus Kidney Development: A Look into β-catenin's Role in Kidney Development
<p>Wnt signaling is a conserved cell communication system that drives embryonic development. Wnt pathways regulate a variety of developmental processes, including cell migration, proliferation, and fate determination. Dysregulation of Wnt signaling can lead to developmental disorders and diseases. …
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Role of Sodium Arsenite in Atherogenesis
… isotypes, α and β, in human aortic endothelial cells (HAECs) and (3) determining the effects of activation of PKC isotypes, α and β, on the endothelial barrier. Accordingly, exposure of ApoE-/- /LDLr-/- mice to As(III) in drinking water showed an increasing trend in atherosclerotic plaque …
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Role of Sodium Arsenite in Atherogenesis
… isotypes, α and β, in human aortic endothelial cells (HAECs) and (3) determining the effects of activation of PKC isotypes, α and β, on the endothelial barrier. Accordingly, exposure of ApoE-/- /LDLr-/- mice to As(III) in drinking water showed an increasing trend in atherosclerotic plaque …
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Mena 11a-isoform specific regulation of actin cytoskeleton organization and cell behavior
… of actin regulatory proteins that modulate cell motility and morphology by altering actin dynamics. Mena, an EnaNASP protein, is alternatively spliced, producing protein isoforms with distinct functions. Here, we characterize the expression, function, and regulation of the Mena11a splice …
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Function of Spectrin cytoskeleton in regulating epithelial architecture.
Epithelial cells surround every organ of the human body and about 85% of cancers arise from epithelial cells. These cells are highly polarized having distinct apical and basolateral sides; they are tightly connected to each other through cell-cell junctions. Epithelial morphogenesis is important …
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Mechanisms of Intercellular Communication During Breast Cancer Progression Through Metastasis
… cancer patient deaths. While the role of intercellular communication in metastasis, either among cancer cells, or between cancer cells and the tumor microenvironment is well established, additional research on specific molecular and cellular mechanisms underlying these interactions is necessary …
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The Role of Wnt Signaling in Bone Mechanotransduction
… are more poorly defined. One important intracellular signal transduction node in the Wnt cascade is β- catenin, which modulates gene expression and cell-cell junctions, among other functions. During periods of disuse, β-catenin is degraded, leading to inhibition of Wnt targets. Here, I …
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A Novel Function For 12-Lipoxygenase In C-Met And Integrin β4 Axis Crosstalk
<p>Cancer cell metastasis is the single most threatening occurrence of tumor progression and predicts patient prognosis as well as survival. Invasion can be regulated by the Met receptor tyrosine kinase (c-Met), integrin beta4, and the lipid enzyme, 12-Lipoxygenase (12-LOX). Therefore we sought to …
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Understanding Human Astrovirus from Pathogenesis to Treatment
… with a down regulation of CDH1 and OCLN, loss of cell-cell junctions most notably at 18 hours post-infection (hpi), and loss of cellular polarity by 24 hpi. While active transforming growth factor- (TGF-) increases during HAstV infection, inhibition of TGF- signaling does not hinder EMT …
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Identifying factors that promote tensional homeostasis in endothelial cells
Various types of mammalian cells have an exceptional ability to adapt to externally applied mechanical stresses and strains. Because of this adaptation, cells can maintain their endogenous cytoskeletal stress at a preferred (homeostatic) state. This homeostasis of mechanical stress in cells, also …
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Regulation of Blood Vessel Development via Rho Family GTPase Signaling
… has been shown to be required in endothelial cells (ECs) during blood vessel formation. However, the underlying cellular events controlled by different GTPases remain unclear. Here, we assess the cellular mechanisms by which Rho family GTPase proteins and their regulators regulate mammalian …
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