Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"cell junction"”.
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The Cytoskeletal Mechanisms of Cell-Cell Junction formation in Endothelial Cells
Intercellular adhesions are essential for compartmentalization and integrity of tissues in an organism, cell-cell communication, and morphogenesis. The actin cytoskeleton and associated proteins play a vital role in establishing and maintaining cell-cell adhesion. However, the procedure by which …
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Cell-Cell Junction Signaling Regulating DNA Double-Strand Break Repair In Breast Cells
… invasiveness through the basement membrane extracellular matrix (ECM) are two major processes for epithelial cell malignancy in breast cancer. DNA double-strand break repair (DSBR) is one of the processes that get misregulated during breast cancer progression. In addition, radiation induced …
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The Effects of Blast-Induced Neurotrauma on Blood-Brain Barrier Permeability, Cell-Cell Junction Protein Levels and the Role of Peroxynitrite
… of blast exposure are not well defined on a cellular level, there is still a need for effective interventions and therapeutics. Here we will discuss a novel rodent model for the study of blast-induced neurotrauma, which we used to investigate the effects of BINT on the blood-brain barrier, …
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A simple coarse-grained model to predict infectious disease outbreak statistics and the consequences of glycolysis inhibition on cell junction mechanics
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms
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Attributes of Astrocyte Response to Mechano-Stimulation by High-Rate Overpressure
… loading. When subjected to such insult, brain cells undergo characteristic injury responses which include neuroinflammation, oxidative stress, edema and persistent glial activation. These features of the injury have emerged as important mediators of the chronic brain damage that results from …
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Cadherin specificity in adhesion and mechanotransduction
Cadherins mediate Ca2+ dependent cell-cell junction in all animal tissues. Tight regulation of cadherin adhesion plays critical roles in diverse biological processes. Differential binding between cadherin subtypes is widely believed to mediate cell sorting during embryogenesis. However, a …
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The role of cad,flash and fam129b in cancer cell survial and apoptosis
… However, apoptosis is desregulated in cancer cells. Most cancer cells gain resistance to apoptosis, leading to uncontrolled proliferation. In this dissertation, we identified three proteins, associated with apoptosis pathway. 1) CAD, a large multifunctional complex that is invariably elevated …
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Dual-Colour STED-microscopy on the Nanoscale
… of biological samples, including proteins of cell-junction and focal adhesion, or a neurofilamental protein from the human brain. Finally, the extension to a Dual-colour STED-microscope was achieved to provide nanoscale precise colocalization ability of individual protein clusters in cell …
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The Novel Role of Dnmbp In Kidney Development
… formation of stable cadherin-mediated adhesion junctions is essential for maintaining cell-cell contacts. To understand the cell behaviors underlying abnormalities in renal morphology and cyst formation and to facilitate the application of novel treatments for congenital birth defects, a better …
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Defining the mechanism(s) of Hepatitis C virus (HCV) entry
… Scavenger receptor BI (SR-BI), and the tight junction (TJ) proteins Claudin-1 and Occludin. Primary HCV strains cannot be efficiently cultured in vitro, making the evaluation of potential antiviral compounds in a biologically relevant context extremely difficult. Despite being suitable for …
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Flow-induced mechanotransduction in cell-cell junctions of endothelial cells
Endothelial cells show an unexpected behavior shortly after the onset of laminar flow: their crawling speed decreases ~40% within the first 30 min, but only in a confluent monolayer of endothelial cells, not in subconfluent cultures, where cell-cell interactions are limited. This led us to study …
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Effects of Liver Extracellular Matrix Gel Stiffness on Primary Hepatocyte Function
The extracellular matrix is a complex environment of mechanical and chemical cues vital to individual cell growth, tissue formation, and ultimately complete organ function. The field of regenerative medicine aims to recreate the unique biological properties found in specific tissue types and to …
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Mechanisms Underlying Variation in Insect Chill Tolerance: The Role of Ion and Water Transport
… and hindgut structural (cytoskeletal and cell junction) genes. Rectal macromorphology and rectal pad scalariform complex ultrastructure were unchanged (suggesting that modified permeability does not involve these structural elements), however cytoskeletal modifications do protect rectal …
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Internally Translated Cx43 Isoform GJA1-20k Affects Epithelial to Mesenchymal Transition and Metastatic Cancer Cell Behavior
… during cancer progression. During this process, cells undergo complex changes at the transcriptional and translational levels leading to dissolution of cell-cell junctions, loss of apical-basal polarity, and cytoskeleton reorganization. Transforming Growth Factor-β (TGF-β) is well-established in …
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Mechanism of CASK-linked ophthalmological disorders
… scaffolding, gene expression regulation, and cell junction formation. CASK is essential for survival in mammals. Heterozygous mutations in the CASK gene (in females) produce X-linked intellectual disability (XLID) and mental retardation and microcephaly with pontine and cerebellar hypoplasia …
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NF1 AS A REGULATOR OF CYTOSKELETON DYNAMICS AND BIOMARKER FOR DECISION-MAKING IN HER2-POSITIVE BREAST CANCER
… process. We generated NF1 knockout (KO) HER2+ BC cells (i.e.: BT-474, SK-BR-3, HCC1954) by CRISPR/Cas9. NF1KO cells demonstrated exquisite sensitivity to the antibody-drug conjugate (ADC) trastuzumab emtansine (T-DM1). This hypersensitivity was specific to the mertansine MT-targeting component …
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Reexamining actin polymerization in maintaining cadherin mediated cell-cell adhesion
Inhibiting actin polymerization disrupts the cell-cell junction showing that continuous actin polymerization is required for maintaining tissue cohesion. The actin cytoskeleton maintains cell-cell cohesion by converting weak homophilic bonds between the cadherin cell adhesion molecules into strong …
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Identification of Cell Biomechanical Signatures Using Three Dimensional Isotropic Microstructures
… biology (BioMEMS) enables precise control of the cellular microenvironments and offers high throughput systems. The focus of this research was to develop three dimensional (3-D) isotropic microstructures for comprehensive analysis on cell-substrate interactions. The aim was to investigate whether …
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ESTABLISHING IN VITRO INTESTINAL EPITHELIAL CELL MODELS IN TRANSLATIONAL ANIMAL NUTRITION
… the effects of n-3 PUFA in porcine IPEC-J2 cell line under (LPS) stress conditions underpinning pig nutrition, combining the state-of-the-art cell-based assays and bioinformatic analysis. The second part of our study was directed towards establishing a primary intestinal epithelial cell …
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Genetic and Biochemical Analysis of the Bryan Strain of Rous Sarcoma Virus
… fibroblast clones were obtained and the provirus-cell junction fragments were mapped by restriction endonuclease cleavage and Southern blotting analyses. We found that expression of the viral genes could occur after proviral integration at many sites on the chicken genome and that there was no …
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