Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 130 for “"cell invasion"”.
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Cancer cell invasion: Guidance in interstitial and muscle tissue
Contains fulltext : 250082.pdf (Publisher’s version ) (Open Access)
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Regulation of Cell Invasion by the Podosome/Invadopod Protein Tks5
… and their impact on the invasive phenotype of cells. The podosomes of macrophages enable tissue invasion during immunosurveillance and wound healing. Using model THP1 macrophages, my studies have shown that Tks5 can directly control podosome-associated matrix degradation and invasion through …
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Abelson Kinase Based Regulation of Tumor Cell Invasion in HNSCC
Nearly 40,000 new cases of head and neck squamous cell carcinoma (HNSCC) are annually diagnosed in the United States. The current standard of care for HNSCC patients consists of chemoradiation often combined with targeted therapeutic agents. However, the five-year survival rate for patients that …
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Modulation of mesenchymal stem cell invasion into decellularized engineered tissues
… the organization and alignment of the extracellular matrix (ECM) in developing and mature tissues, where the organization gives the tissue its unique functional properties. This dissertation will discuss research that is fundamental to the understanding of the interaction of cells with the …
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Cellular Plasticity And Heterogeneity: Implications In Tumor Cell Invasion And Metastasis
The existence of heterogenous subpopulations of cells in cancer has been shown to arise via natural evolution or through movement between cellular states collectively known as “cellular plasticity.” This heterogeneity and plasticity are critical drivers of phenotypic diversity culminating in many …
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A NOVEL PRO-OXIDANT ROLE OF GELSOLIN IN CANCER CELL INVASION
Although gelsolin is often implicated in cancer cell invasion, the mechanisms remain poorly understood. We have identified a new role of gelsolin in creating a pro-oxidant milieu thereby enhancing cancer cell invasion. Increased gelsolin expression in HCT116 results in heightened ROS levels, …
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Fatty Acid-Mediated Inhibition of Host Cell Invasion by Cryptosporidium Parvum
… that inhibits Cryptosporidium parvum sporozoite invasion of host cells in vitro. A panel of similar lipids with varying chain lengths and degrees of saturation were tested for evidence of inhibitory activity in order to determine the range of specificity. We identified a subset of inhibitory …
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Effect of broccoli bioactives on prostate cancer cell invasion in vitro
… that broccoli bioactive components inhibit invasion of human prostate cancer cell line, DU145, in an in vitro model system. DU145 cells were plated into Matrigel invasion chambers placed in 24-well plates with complete growth medium as a chemo-attractant. In the chambers, cells were treated …
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MECHANISMS BY WHICH XRCC3 MEDIATES BREAST CANCER CELL INVASION VIA CYCLOPHILIN A
… 3 (XRCC3), has been shown to increase breast cell invasiveness. This raises the question of whether XRCC3 is a positive modulator of invasion or whether overexpressed XRCC3 is trapped in non-functional complexes, resulting in a dominant negative effect. To address this we transiently …
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Identification and Characterization of Determinants of Head and Neck Tumor Cell Invasion
<p>Head and neck squamous cell carcinoma (HNSCC) is a common malignant disease with poor prognosis. The majority of patients die from local invasion or lymphatic metastasis. The mechanism(s) underlining the invasiveness of HNSCC are poorly understood. Utilizing a panel of HNSCC cell lines …
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Microrna-200 Regulates Ecm-Dependent Β1-Integrin/Fak Signaling and Cancer Cell Invasion
… have shown that the miR-200/Zeb1 axis regulates cell-cell and cell-matrix interactions, but it has also been demonstrated that cell-intrinsic changes are insufficient to drive cancer cell invasion, leading us to focus on specific cell-matrix interactions required to activate tumor cell invasion …
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Bone Marrow Stromal Cell Invasion and Bone Regeneration in Enzymatically-Degradable Osteoinductive Hydrogels
… In the first part, the effect of conjugation of cell adhesion RGD peptide and osteogenic peptide KIPKA SSVPT ELSAI STLYL to a model biodegradable hydrogel on osteogenic differentiation of BMS cells and production of mineralized matrix was studied. RGD peptide was grafted to the hydrogel by adding …
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Src Kinase Regulates TGFβ And Hyaluronan Induced Epicardial Cell Invasion, Differentiation And Migration
… relies on growth factor as well as extracellular matrix (ECM) influences on cells of the epicardium that regulate proliferation, motility, invasion and differentiation. The Transforming Growth Factor β (TGFβ) family of receptors have been well described in regulating cardiovascular …
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A study of the mechanism of action of novel inhibitors of tumour cell invasion
… cause of death in cancer patients. Tumour invasion and migration are critical aspects of metastatic progression. A forward chemical genetics project was initiated in an effort to identify novel compounds that inhibit tumour invasion. After screening a natural extract library, two novel …
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Invesitagating the role of the guanine nucleotide exchange factor P-Rex1 in cell invasion
Cell invasion is a critical step in cancer metastasis. Rho family GTPases are key regulators of cell motility, regulating the form and function of the actin cytoskeleton. P-Rex1, a Rac guanine nucleotide exchange factor (GEF), was previously identified in this lab in a transcriptional screen for …
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The hypoxic tumor microenvironment regulates the LPA signaling axis to promote cancer cell invasion and metastasis
… tumeurs solides, est fortement impliquée dans l'invasion cellulaire et le développement des métastases, mais les mécanismes sous-jacents demeurent méconnus. La signalisation du LPA joue un rôle important au cours de la tumorigenèse et du développement des métastases, les membres de cette voie …
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Αvβ8 Integrin Interacts With Rhogdi1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion
… Adhesion and signaling pathways that drive GBM cell invasion remain largely uncharacterized. Here we have utilized human GBM cell lines, primary patient samples, and pre-clinical mouse models to demonstrate that integrin αvβ8 is a major driver of GBM cell invasion. β8 integrin is overexpressed …
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The Regulatory Role of Mixed Lineage Kinase 4 Beta in MAPK Signaling and Ovarian Cancer Cell Invasion
… kinase (MAPK), which in turn regulates different cellular processes including proliferation and invasion. Here, we show that the beta form of MLK4 (MLK4beta), unlike its close relative, MLK3, and other known MAP3Ks, negatively regulates the activities of the MAPKs, p38, ERK and JNK, even in …
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