Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 178 for “"cell interactions"”.
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Investigating Tumour-Immune Cell Interactions in Paediatric Malignancies
… particular, we lack a complete understanding of interactions between the patient’s immune system and tumour. We hypothesised that biological properties of tumours that do not respond to immunotherapy can be detected prior to treatment and serve as biomarkers for patient selection. Furthermore, we …
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Real-Time Bioluminescence Imaging Of Salmonella-Neoplastic Cell Interactions
… and replicate in host intestinal epithelial cells and macrophages. Interestingly, Salmonella is also capable of localizing to tumors in in vivo model systems, and while the typical route of Salmonella infection and pathogenesis has been thoroughly investigated, the behavior of Salmonella in …
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Probing the role of cell-cell interactions in hepatic ensembles
… is scarce. Alternatives such as engineered cell-based therapies aim to restore tissue-specific functions of solid organs, but leave much to be desired. Key challenges hindering the translation of cell-based therapies relate to (1) cell sourcing, (2) graft scale-up, and (3) vascularization, …
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Controlling cell-cell interactions in hepatic tissue engineering using microfabrication
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1997.
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Single-cell Analysis of Structural and Immune Cell Interactions in Periodontitis
… insight into inflammatory pathways, single-cell RNA sequencing (scRNA-seq) enables detailed characterization of cell-type–specific responses and coordinated interactions within the periodontal microenvironment. OBJECTIVE: This study aimed to compare the transcriptional landscapes of …
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Targeting bone-microenvironment-tumour cell interactions : IGF-1 receptor kinase inhibitors.
… to set up a model system for the study of tumour cell – bone cell interactions in vitro, ex vivo and in vivo and to use this system to test the efficacy of a novel therapeutic agent for the treatment of osteolytic bone disease. Co-culture or conditioned medium studies using human or mouse cancer …
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Imaging studies of glycan mediated breast cancer epithelial cell-endothelial cell interactions
… organs in the body. Aberrant glycosylation of cell surface glycoproteins in cancer cells has been implicated in promoting cancer metastasis and consequent poor survival of cancer patients. In particular, aberrant glycans terminating in α-N-acetylgalctosamine (GalNAc), specifically recognized by …
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Bidirectional Natural Killer Cell and Dendritic Cell Interactions in HIV-1 Pathogenesis
Natural killer (NK) and dendritic cell (DC) interactions are pivotal for the development of immune responses, which lead to bidirectional NK:DC activation. In HIV-1 infection, both NK cell and DC function are impaired, resulting in dysfunctional NK:DC crosstalk. We demonstrate that NK:DC …
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Profiling the neurovascular cell interactions in alcohol exposure and HIV-1 infection
… gp120) in the setting of interactive neuroimmune cell culture (brain endothelial cells, astrocytes, microglia, and neurons) with or without the presence of alcohol. The synergistic effect of alcohol on HIV associated neurotoxicity will pave the future research path to examine the unique mechanism …
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Analysis of Cell-Cell Interactions in the Formation of Drosophila Antennal Lobes
… Drosophila brain extends our knowledge of their cellular functions and helps to shed light on the pathology of human genetic diseases.
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Pericyte-Endothelial Cell Interactions during Blood Vessel Formation and in Diabetic Scenarios
… retina microvasculature. Specialized vascular cells known as pericytes (PCs) are lost or become dysfunctional during disease progression; a thickening of the extracellular matrix (ECM) composing the vascular basement membrane (vBM) and endothelial cell (EC) tight junction disruption are also …
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The Roles of daf-6 and Cell-Cell Interactions in Sensory Organ Morphogenesis
<p>The development of multicellular organs depends on the regulation of cell shape, position, and orientation. The genetic regulation of these morphogenetic processes is poorly understood. As a model for organ morphogenesis, I studied the development of the Caenorhabditis elegans amphid sensory …
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An improved in vitro model for the study of Mycobacterium leprae/Schwann cell interactions
… of Mycobacterium leprae infection. Schwann cells, the neural target of M. leprae, have a central role in leprosy histopathology including axonotrophy, altered myelin architecture and demyelination. The mechanisms of nerve damage have not been fully elucidated but appear to be the direct …
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Homeostatic mechanics for a synthetic cell: predictions on substrate anisotropies and cell-cell interactions
… one or more biological processes, which in cells are known to be highly coupled. This added complexity limits the control over the biocompatibility and biofunctionality of the designed tissues. Amongst the many degrees of freedom in question, substrate topological and mechanical properties, …
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In-vitro Modelling of Stromal and Immune Cell Interactions Following Surgical Bone Marrow Stimulation
… of a haematoma containing Bone Marrow Stromal Cells (BMSC) and immune cells at the joint surface, leading to repair. However, the quality of repair after marrow stimulation is, at present, sub-optimal. BMSC are known to interact with immune subpopulations during repair, although the …
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Dynamic Assessment of Nk Cell Interactions With Pediatric Tumor Cells to Predict Response to Immunotherapy
<p>Due to Natural Killer (NK) cells’ capacity to target tumor cells without prior sensitization, adoptive NK cell therapy represents a promising immunotherapy approach for pediatric cancer patients. Our laboratory has developed an NK cell expansion protocol that generates large quantities of NK …
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Molecular engineering of gold nanorod surfaces: towards improved physical properties and understanding nanoparticle-cell interactions
… in nanorods aggregation and toxicity to cultured cells. Herein, three surface-engineering approaches to enhance the colloidal physical stability and biocompatibility of gold nanorods have been examined: 1) electrostatic approach via overcoating with polyelectrolytes; 2) covalent approach via …
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The role of inherited determinants and embryonic-extraembryonic cell interactions in models of mammalian embryogenesis
… of an oocyte and a sperm to create the first cell of the newly developing embryo called the zygote. The mechanisms by which this single cell generates a fully formed organism have long been the subject of study of experimental biologists. Initially, embryonic development is reliant on …
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Molecular dissection of macrophage-tumour cell interactions to identify novel treatment strategies for pancreatic cancer
… radiation treatment and chemotherapy. PDAC cells are highly motile and invasive resulting in infiltrative PDAC with poorly defined borders. PDAC tumours are heavily infiltrated with fibroblasts and subpopulations of immune suppressive cells, macrophages, which we demonstrate to stimulate …
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