Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 126 for “"cell infiltration"”.
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Anti-VEGF Therapy Modulates Immune Cell Infiltration and Function in Multiple Breast Cancer Models
… cancer is initiated when mammary epithelial cells acquire mutations in genes that regulate cell proliferation, survival, polarity, and differentiation. However, a growing body of evidence indicates that the stromal cell response to these malignant cells participates in tumorigenesis and is …
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Electrospun Blends of Polydioxanone and Fibrinogen for Urological Applications
… characterized, as well as mechanical strength. Cell proliferation assays for 1 and 7 day cultures were preformed, and a histological evaluation was performed to determine how favorable the various blends were to cell infiltration and proliferation. Some ratios of blends were identified that …
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Preparation and Characterization of Electrospun rGO-Poly(ester amide) Tissue Engineering Scaffolds
… relevant stimuli and through successful cell infiltration. External electrical stimulation is particularly relevant for cardiac and neural applications, and requires conductive scaffolds to propagate electrical signals; cell infiltration is only possible with scaffolds that have …
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Histopathology of livers and native organs of recipients following genetically-engineered pig-to-baboon liver xenotransplantation
… in liver sinusoids, and vascular endothelial cell hypertrophy. Immunohistochemistry showed minimal deposition of IgM, and almost absence of IgG, C3, C4d, C5b-9, and of a cellular infiltrate, suggesting that neither antibody- nor cell-mediated rejection played a major role. In project 2, when …
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HEPATOCYTES COORDINATE A SYSTEMIC ENDOCRINE NETWORK IN CANCER
T cell infiltration into tumors is a favorable prognostic feature. However, the majority of solid tumors lack productive tumor T cell immunity, and the mechanisms that coordinate T cell exclusion remain incompletely understood. Accumulating evidence suggests that while cancer cell intrinsic and …
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Modulation of the tumor microenvironment by the CXCR4 antagonist AMD3100 in pancreatic and colorectal adenocarcinoma
… genetically engineered mouse model of PDAC, T cells are excluded from tumour nests and this effect is related to the chemokine CXCL12 produced by FAP+ stromal cells. Targeting the CXCL12/CXCR4 pathway with AMD3100, a CXCR4 antagonist, resulted T cell infiltration and tumor regression with …
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Investigating the protective effects of intestinal GABA[subscript A] receptor activation on an animal model of Multiple Sclerosis
… are found not only in the CNS, but also in T cells and within the intestines. Past studies have indicated that GABA can have an anti-inflammatory effect and production of GABA by gut bacteria decreases in patients with multiple sclerosis (MS). We examined whether administration of a positive …
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Effect of Electrospun Mesh Diameter, Mesh Alignment, and Mechanical Stretch on Bone Marrow Stromal Cells for Ligament Tissue Engineering
… three steps: seeding bone marrow stromal cells (BMSCs) onto electrospun scaffolds, processing them into cords that allow cell infiltration, and conditioning them with uniaxial cyclic stretch. These steps were addressed in three complimentary studies to establish new methods to engineer a …
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Role of Slit2 in Reducing Complications after Surgical Brain Injury
… and plasma proteins as well as peripheral immune cell infiltration into the brain parenchyma that further potentiates brain edema and worsens post-operative neurological function. Activated resident immune cells and infiltrated peripheral immune cells release inflammatory mediators and promote …
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Investigation of local South African avipoxviruses as potential vaccine vectors
… use as vaccine vectors as a result of their excellent safety profile and host range restriction. In this study, 8 novel South African (SA) avipoxvirus isolates were characterized. They could be divided into five groups, according to gross pathology and pock appearance on CAMs. Histopathology …
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Absence of Enhancer of Zeste Homolog 2 Promotes the Progression of KRAS-Driven Pancreatic Ductal Adenocarcinoma
… but did affect progression, and reduced immune cell infiltration, suggesting a role for EZH2 in limiting early progression of KRASG12D-mediated PDAC.
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Pre-operative ablative radiotherapy in combination with immunotherapy and novel agents in pancreatic cancer
… with immune checkpoint blockade can enhance T cell infiltration and T cell mediated tumour cell death. However, the potential for RT to modulate the tumour immune micro-environment in PDAC, using clinically relevant RT doses is unknown. The aim of this project was to investigate the potential …
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Characterization of Immune Cell Populations in White Adipose Tissue of Wild Type and Bovine Growth Hormone Transgenic Mice
… mostly of adipocytes, but contains other cell types, including a variety of immune cells such as macrophages, T cells, Natural Killer T cells (NK), and depot specific differences in cellular composition and endocrine output. Growth hormone (GH) has been shown to impact immune function as …
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Factors contributing to T cell persistence in a tolerizing tumor environment
… chemotherapy and immunotherapy. CD8[+] T cells are adaptive immune cells responsible for eradicating tumor cells. However, these T cells can be rendered ineffective through tolerance. Yet in various mouse models and human patients, tolerant T cells persist. The aim of this project is to …
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Strategies for the Fabrication of Cellularized Micro-Fiber/Hydrogel Composites for Ligament Tissue Engineering
… growth and differentiation of mesenchymal stem cells toward many tissue lineages including ligament. However, these micro-fiber networks do not possess suitable sizes and shapes for a ligament application and cannot support cell infiltration. The objective of this work was to develop techniques …
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Investigating The Role of Abro1 In Dna Damage-Induced Immune Response
… such as enlarged spleens, increased numbers of T cells and B cells, elevated levels of IL6 and TNF-alpha in the blood, and increased immune cell infiltration in major organs. Recently, it has been shown that genomic instability can trigger cGAS/STING pathway , inducing activation of the innate …
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Myeloid cells induce neurofibromatosis type 1 aneurysm formation through inflammation and oxidative stress
… activity in both hematopoietic and vascular wall cells, which are critical for maintaining blood vessel homeostasis. NF1 patients are predisposed to chronic inflammation and premature cardiovascular disease, including development of large arterial aneurysms, which may result in sudden death …
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Imaging Glioblastoma metabolism using mass spectrometry imaging
… such as proliferation rate, immune cell infiltration, hypoxia, or vascularisation. Growing cells outside the primary tumour as primary cell lines and then implanting them orthotopically into rodent brains did not change their metabolic phenotype. In addition, modulation of the …
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Role of peroxisome proliferator-activated receptors in mechanisms of rejection in heart transplantation
… graft IFN[gamma] expression and inflammatory cell infiltration, thereby augmenting PR without ameliorating TxAA. Congenital deficiency of PPARα confirmed that the receptor plays a regulatory role in IFN[gamma] expression but is not necessary for graft infiltration by inflammatory cells. The …
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Potentiation of The Immune Checkpoint Blockade Response By Metabolic Modulation Is Predictable Using Molecular Imaging
<p>Unregulated cell division is a hallmark of cancer. The high metabolic needs of the tumor cells result in nutrient depletion and produce a hostile tumor microenvironment (TME) for antitumor immune cells, protecting the tumor from immune cell-mediated control and immunotherapy. Two of these …
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