Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 181 for “"cell imaging"”.
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Evaluation of radiotracers for beta cell imaging
Contains fulltext : 169275.pdf (Publisher’s version ) (Open Access)
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Fluorogenic probes for live-cell imaging of biomolecules
… application of these probes to study dynamic cell transport processes. Chapter 1. Enzyme-Activated Fluorogenic Probes for Live-Cell and In Vivo Imaging. Chapter 1 reviews recent advances in enzyme-activated fluorogenic probes for biological imaging, organized by enzyme classification. This …
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DEVLOPEMNT OF FLUORESCENT IMAGING TOOLS FOR LIVE CELL IMAGING
… there is a growing interest to understand cellular processes and behaviors in real time. Fluorescent live cell imaging presents an appealing approach to learn about cell dynamics and function by providing specificity and high resolution. However, one of the biggest limitations of these …
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Development of 89Zirconium-PET Tracers for Immune Cell Imaging
The use of cell-based therapies as a living drug have gained considerable attention for the treatment of a range of conditions such as genetic diseases, autoimmune disorders and cancer. The emergence of genetically engineered T cells expressing chimeric antigen receptors (CAR T-cells), together …
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Advancing Fluorescence Microscopy Techniques for Volumetric Whole-cell Imaging
… the last decade has been the application of new imaging methods to modern biology, revealing new insights into cellular structure and dynamics. However, imaging methods capable of three-dimensional (3D) imaging at high spatial and temporal resolution are still lacking. This thesis describes two …
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Quantitative Single-Cell Imaging Reveals Insulation of Morphogenic Signal Transduction
How cells integrate external cues in order to make behavioral decisions is a central problem of cell biology. In development and in tissue-homeostasis, cell-fate decisions are made by the integration of multiple morphogenic signals, but how cells convert such combinations of signals into distinct …
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Trimethoprim-Based Chemical Tags for High Resolution Live Cell Imaging
… the use of fluorescent proteins in live cell imaging. Chemical tags retain the specificity of protein labeling achieved with fluorescent proteins through genetic encoding, but provide smaller, more robust tags and modular use of organic fluorophores with high photon-output and tailored …
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Live cell imaging of protein trafficking: Dynamics and functional insights
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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LIVE CELL IMAGING BY INTEGRATING FLUORESCENCE AND MOTION- ENHANCED DIFFERENTIAL INTERFERENCE MICROSCOPY
… Now, we have developed methods for simultaneous imaging using short wavelength DIC/MEDIC and standard fluorescence microscopy. Our novel method of integrating MEDIC and fluorescence imaging provides the tag-free contrast-enhanced advantages of MEDIC and the high specificity of fluorescence …
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New tools for live cell imaging of endogenous loci in mammalian cells
Embargo set by: Seth Robbins for item 116313 Lift date: 2022-10-07T22:50:13Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system
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Conjugation of Biological and Carbon Nanoparticles For Applications In Electronics and Cell Imaging
… extensively studied for applications in cancer cell targeting, imaging, and drug delivery. Carbon-based quantum dots, or Selah Dots, were conjugated with fluorescent dye molecules to improve their fluorescent signal, and cell targeting ligands were conjugated to improve the cell targeting …
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Ruthenium polypyridyl complexes with long aliphatic chains; photophysics, interfacial assembly and cell imaging
… complexes with monoclonal cells and their suitability as luminescence cell imaging probes. A CHO cell line (Chinese hamster ovary cell) were stained with the Ru(dpp)2(x-ATAP)](PF6)2. This series of complexes was capable of crossing the cell membrane barrier and localizing in …
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Rational design and directed evolution of probe ligases for site-specific protein labeling and live-cell imaging
… However, in order to use these probes for live-cell protein imaging, highly specific labeling methods are required. Here, we will describe three efforts to re-engineer the E. coli enzyme, lipoic acid ligase (LplA), to catalyze the ligation of small-molecule probes onto recombinant proteins. We …
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Development of a Real-Time Cell Imaging Assay to Characterize the Delivery of a Cell-Penetrating Peptide Adaptor and its Associated Cargo
<p>Cell-penetrating peptides (CPPs) are small peptides capable of transporting molecules across the membrane. In most cases, the membrane is a blockade that prevents molecules from entering the cell, therefore CPPs have attracted much attention. Although CPPs are effective, this system is still …
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Design and synthesis of Push-pull chromophores for cell imaging and OPV devices [Progettazione e sintesi di cromofori Push-pull per l'imaging cellulare e i dispositivi OPV]
… sviluppati per due applicazioni avanzate: l’imaging cellulare e il fotovoltaico organico (OPV). Unificate dall’integrazione strategica di gruppi donatori-accettori nelle architetture molecolari oggetto di studio, le ricerche sono articolate in due capitoli, ciascuno dedicato a una specifica …
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Microfluidics and live imaging advances: applications in host/pathogen, immunity and stem cell single cell phenotyping
Live single-cell imaging has emerged as an advanced single-cell study tool for approaching a quantitative understanding of many biological questions in recent years. In previous cell studies using bulk cell measurements, the population averages can miss the information from cell to cell variability …
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Compressed fluorescence lifetime imaging microscope
Fluorescence lifetime imaging microscopy (FLIM) has been extensively applied in wide biomedical applications from single cell studies to medical diagnosis. While the state-of-the-art FLIM techniques are highly sensitive to biological dynamics such as fluorescence resonance emission transfer (FRET), …
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Synthesis of Fluorene-based derivatives, Characterization of Optical properties and their Applications in Two-photon Fluorescence Imaging and Photocatalysis
… used are three-dimensional (3D) fluorescence imaging and optical power limiting. Two-photon absorbing materials are, therefore, in great demand to meet the needs of emerging technologies. Organic molecules show great promise to meet this need as they can be customized through molecular …
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Chemical Tools for Exploring IFITM3 S-Palmitoylation and Mechanism
… of S-palmitoylated proteins in dendritic cells and macrophages by our laboratory revealed that the interferon-induced transmembrane proteins (IFITMs) are S-fatty-acylated at conserved cysteine (Cys) residues. IFITMs are unique interferon-induced proteins that restrict the infection of …
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