Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"cell heterogeneity"”.
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Androgen Receptor and Prostate Cancer Cell Heterogeneity
… However, the functional significance of AR heterogeneity in regulating PCa biology and response to androgen/AR-targeted therapies remains unclear. The overarching hypothesis for my Ph.D is that <strong>AR heterogeneity contributes to PCa development, progression, and therapy …
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Beta Cell Heterogeneity in the Acute Interferon Alpha Response
… destruction of the insulin-producing β-cells in the pancreatic islet. This autoimmunity is hypothesized to result from a combination of genetic and environmental factors, with early childhood viral infection being a leading hypothesis for the latter. In response to viral infections, the …
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Investigating The Single Cell Heterogeneity and Physiological Impact of Mistranslation
… grow clonal populations; however, individual cells have a variety of phenotypes. The physiological heterogeneity observed in populations has been attributed to variations in the processes of gene expression. For example, promoter expression has been shown to be heterogeneous within a …
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Engineering pluripotent stem cell heterogeneity and its effects on differentiation
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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Hepatic stellate cell heterogeneity and function during the hepatic regenerative response
… the only curative treatment. Hepatic stellate cells (HSCs) play a central role during liver injury and regeneration, driving matrix remodelling and impacting proliferation and differentiation of other hepatic cell types2,3. Traditionally HSCs were considered a homogenous population, with global …
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Mechanisms of CD4+ Regulatory T Cell Heterogeneity in Health and Disease
Regulatory T (Treg) cells are central to the maintenance of immune homeostasis and their dysfunction underlies the pathology of numerous diseases. Treg cell populations are phenotypically heterogeneous, comprising functionally quiescent resting Treg (rTreg) cells, which upon antigen stimulation, …
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Targeting of specific developmental pathways to understand dendritic cell heterogeneity and function
Dendritic cells (DC) are cells of the immune system that are specialized in sensing and responding to pathogens. They coordinate innate and adaptive immune responses to different types of pathogens through the release of inflammatory cytokines, secretion of interferon, and presentation of antigen …
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Vascular smooth muscle cell heterogeneity and plasticity in models of cardiovascular disease
Vascular smooth muscle cell (VSMC) accumulation is a hallmark of atherosclerosis and vascular injury. However, fundamental aspects of proliferation and the phenotypic changes within individual VSMCs, which underlie vascular disease remain unresolved. In particular, it is not known if all VSMCs …
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Integrative Bioinformatics Approaches to Elucidating Prostate Cancer Cell Heterogeneity, Plasticity, and Treatment Response
… metastatic and therapy-resistant cancer cells. Cancer stem cells (CSC) are an important contributor to this tumor heterogeneity, which are present in primary tumors and become enriched in castration resistant PCa (CRPC). Our lab has demonstrated that the prostate cancer stem cells (PCSCs) …
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Studying Myeloid Cell Heterogeneity After Spinal Cord Injury via Time-Resolved Single-Cell RNA Sequencing
… resident microglia and infiltrating myeloid cells. However, the precise role of these myeloid cell subsets remains unclear as upon crossing the blood-spinal cord barrier (BSCB), infiltrating monocyte-derived macrophages may take on the morphology of microglia, and upregulate canonical …
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Investigation of CD4+ T cell heterogeneity and function in a genetic mouse model of lung adenocarcinoma
… immunosuppressive mechanisms is needed. CD4+ T cells, which are phenotypically diverse, orchestrate many diverse components of immune responses, and can contribute to tumor growth through a variety of mechanisms. Regulatory T cells (Tregs) in particular are an immunosuppressive subpopulation of …
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Cytometry of Reaction Rate Constant (Crrc): Optimization of the Technique and Development of a Novel Protocol to Assess Cell Population Heterogeneity Based on Aldh1a1 Activity in Vitro
… a novel analytical technique which aims to study cellular heterogeneity based on the activity of enzymatic reactions. In the past, CRRC was able to assess cellular heterogeneity in vitro by investigating the activity of ABC-transporter enzymes. However, CRRC showed poor robustness to highly motile …
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DEVELOPMENT OF SINGLE-CELL MASS SPECTROMETRY TOOLS TO INVESTIGATE METABOLIC REORGANIZATION DURING EARLY EMBRYOGENESIS
Measurement of metabolism in single cells holds the potential to advance our understanding of fundamental biological processes during cell differentiation and development. However, to characterize the metabolic state of single cells, further technological advances are still required. This …
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Modeling of gene regulatory networks controlling cell-fate decisions in Bacillus subtilis
To adapt to various environments, bacterial cells can activate distinct gene-expression programs and differentiate into mutually exclusive cell types. This process is called cell-fate decision. Bacillus subtilis is a well-studied model system for investigating bacterial cell-fate decisions. In …
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Multiplexed angiogenic biomarker quantification on single cells
Clinical and biomedical research seeks single-cell quantification to better understand their roles in a complex, multi-cell environment. Recently, quantification of vascular endothelial growth factor receptors (VEGFRs) provided important insights into endothelial cell (EC) characteristics and …
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Development and application of a microfluidic platform for single-cell cultivation of CHO suspension cell lines
… manufacturing facilities mostly mammalian cell lines are applied in stirred-tank bioreactor-based bioprocesses to yield diverse products ranging from monoclonal antibodies to growth factors or pharmaceutical enzymes. Predominantly, Chinese hamster ovary (CHO) cells are utilized in these …
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The design and statistical analysis of single-cell RNA-sequencing experiments
… molecular content at the level of individual cells. One goal of this research is to put forward best practices in the design of single-cell RNA-sequencing (scRNA-seq) experiments, specifically as it relates to choices regarding the trade-off between sequencing depth and sample size. In …
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Spatially organized fluorescent reporters for recording complex biological dynamics in cell population
… protein kinases, interact in complex ways within cells, and can exhibit great cell-to-cell heterogeneity as a function of cell history and state. There is increasing desire to use multiple fluorescent reporters to simultaneously measure multiple biological signals in single cells across cell …
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Activin signaling controls a wound-induced program essential for regenerative patterning
… signaling from specific subsets of muscle cells. Furthermore, several of these subsets have been shown to express specific transcription factors, for which inhibition results in specific patterning phenotypes. Muscle heterogeneity and function in regeneration can be further studied through …
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Investigating Roles for Cellular Heterogeneity in Cancer
Cell populations, even those derived from a single clone, can exhibit a high degree of phenotypic variability. However, most biological studies take measurements as averages of entire populations without consideration for the underlying distribution of cellular phenotypes. Though there is growing …
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