Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"cell growth and division"”.
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Studies on the Teichoic Acids of the Pneumococcus
… of the pneumococcal wall teichoic acid during cell growth and division. Teichoic acid was labeled with <sup> 3</sup>H-choline (a teichoic acid-specific constituent of pneumococci) or an analogue, and its distribution among progeny cells over several generations was followed by autoradiography. …
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An individual-based GPU simulation framework for collective bacterial dynamics in swarms and biofilms
… recent technological advancements, observations and measurements of complex bacterial communities at single-cell resolution are now possible. Guided by these rich experimental data sets, we develop minimal individual-based models to uncover the governing forces driving the dynamics in microbial …
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Metabolic regulation of mammalian cell growth and proliferation
Proliferation requires that cells acquire sufficient biomass to produce two daughter cells. To accomplish this, cells must utilize available nutrients to generate new components of cell mass, including proteins, lipids, and nucleic acids. In addition, cells must coordinate biosynthesis and …
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Computational Modeling of Bacterial Biofilms
With recent advances in experimental imaging and image analysis techniques, highly time-resolved measurements of complex bacterial communities at single-cell resolution are now possible to obtain. Guided by these rich experimental data sets, we improve a recently proposed three-dimensional …
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Mathematical Modelling of Mechanisms for Biofilm Expansion
Biofilms are multi-cellular communities of microorganisms attached to surfaces. It has been estimated that about 99% of all bacteria exist in biofilm. Thus to understand the critical role bacteria play in natural and man-made ecosystems, requires a better knowledge of these multi-cellular …
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Functional Investigation of Trypanosoma brucei Microtubule Associated Proteins and Their Role in Cellular Morphogenesis.
… requires extensive remodelling during cell growth and division. Microtubule nucleation/outgrowth and coordinated severing/re-establishment of inter-microtubule cross-links is orchestrated by microtubule associated proteins (MAPs). The T. brucei genome encodes a discrete set of …
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Posttranscriptional gene silencing of p27 in primary prostate epithelial cells by small inhibitory RNA (siRNA)
The cell cycle is an ordered set of events, culminating in cell growth and division into two daughter cells. The cell cycle is regulated by the intricate interplay of many molecules. Cdks (cyclin dependent kinases), along with cyclins, are major control switches for the cell cycle, causing the cell …
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Optimization of BRAF V600 Assay as A 2-Step Real-time PCR Protocol
… abnormally active, which disrupts regulation of cell growth and division. Mutations in this gene have been found in cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, papillary thyroid carcinoma, non-small-cell lung carcinoma, gastric cancer, and even prostate cancer. …
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Quantitative characterisation of single-cell circadian rhythms in cyanobacteria Synechococcus elongatus
… living systems to adapt to environmental cycles and anticipate the changes in their surroundings. To perform their functions, the clocks must be sensitive to the entraining cues and simultaneously resilient to perturbations in their environments. It is unclear how clocks have evolved to find this …
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Structural and Functional Studies of Escherichia coli Kinases and Phosphatases
… many diverse biological events triggered by extracellular effectors. Moreover, it is a ubiquitous element of intracellular signal transduction pathways that regulates a wide range of processes. While protein phosphorylation has been extensively characterized in eukaryotes, far less is known about …
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Silicon photonic microring resonators for the development of cancer protein biomarker assays
… referred to as simply ""cancer,"" uncontrolled cell growth and division in a human body is often the result of a variety of biochemical perturbations. Efforts to improve diagnosis and treatment of cancer patients are increasingly relying upon more detailed individual biochemical information—i.e. …
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High level indole signalling in Escherichia coli
… which converts tryptophan into indole, pyruvate and ammonia. Indole has diverse roles in E. coli, including regulation of biofilm formation, acid resistance and pathogenicity. In these cases, E. coli responds to a low, persistent level of indole (0.5-1 mM), similar to the concentration found in …
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Effects of co-expression of chaperone combinations on production of soluble plasmodial protein PfAdoMetDC in E. coli
… of polyamines, such as putrescine, spermidine and spermine. Polyamines play a major role in the survival of the malaria parasite. They are critical components of cell growth and division, particularly in rapidly proliferating cells that include cancerous cells and numerous parasites. Hence, …
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Synthesis and Biological Studies of Lanthionine Derivatives
… for PG allowing to identify novel antibiotics and worthy target for inhibition. In Escherichia coli, meso-diaminopimelic acid (A2pm) is a key molecule for reticulation of PG. During this work, we synthesized meso-lanthionine, the monosulfur analogue of meso A2pm, and some of its derivatives. As …
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An integrated approach to understanding the metabolic rewiring of cancer cells
… remains a leading worldwide health problem, and in the U.S., 1 in 3 women and 1 in 2 men are expected to develop it during their lifetimes. While the last several decades have provided tremendous understanding of the genetic mutations and signaling pathways that give rise to oncogenic …
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CELL DIVISION AND EMBRYOGENIC COMPETENCE IN ALFALFA {Medicago falcata L.)
… of the swollen leaf tissue was disrupted and after 15 days the globular clusters of small dividing cells (pro-embryos) which had formed within the leaf tissue were released into the medium. After transfer to a development medium, the pro-embryos proceeded through the classical heart and …
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Organization of the Streptococcal ExPortal and its Interaction with Cationic Antimicrobial Peptides
<p><italic>Streptococcus pyogenes<italic/> and other Gram-positive pathogens are highly dependent on secreted virulence proteins for their ability to colonize a host and evade the immune effectors that act on pathogens to prevent this. Unlike eukaryotes and Gram-negative bacteria, all Gram-positive …
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Selective Isolation of Circulating Tumor Cells in Antibody-Functionalized Microsystems
Attachment of circulating tumor cells in microfluidic devices functionalized with proper antibodies was studied. Under static experimental conditions, microchambers were utilized to study the parameters such as cell suspension concentration, incubation time or ambient temperature that may affect …
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Phytoplankton growth and diel variations in beam attenuation through individual cell analysis
… beam attenuation, with a minimum near dawn and a maximum near dusk, and have assumed them to be caused by the phytoplankton. In an attempt to understand these patterns, mean forward light scatter of different populations of phytoplankton, from flow cytometric analysis of individual cells, …
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Biochemical Studies of Peptidoglycan Hydrolases from Commensal and Pathogenic Bacteria
… microbiota consists of diverse bacterial species and their effectors that play key roles in regulating human health. Interestingly, cell wall, or peptidoglycan, fragments from commensal and pathogenic bacteria can activate host immunity. The mechanism(s) by which immunologically active …
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