Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 908 for “"cell growth"”.
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Role of MDM2 In Cell Growth Regulation
… to induce G0-Gl/S phase arrest. To determine the cell cycle step targeted by MDM2, flow cytometry was employed to detect induction of events during the G1-S phase transition in MDM2-arrested cells. MDM2 overexpression does not prevent expression of cyclin D, cyclin D-CDK mediated phosphorylation …
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The Role of Pyruvate Dehydrogenase in Cell Growth
Otto Warburg's observation that tumor cells have increased rates of glucose uptake and lactate secretion in comparison to normal cells spawned his notion that tumors have dysfunctional mitochondria. However, in addition to metabolizing glucose to lactate, tumors in vivo exhibit mitochondrial …
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Downregulation of Pax2 Suppresses Ovarian Cancer Cell Growth
… genes regulating tissue development and cellular differentiation in embryos. <em>PAX2</em> promotes cell proliferation, oncogenic transformation, cell-lineage specification, migration, and survival. Unattenuated <em>PAX2</em> has been found in several cancer types. We therefore sought to …
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Three-Dimensional Scaffolds for Mammary Epithelial Cell Growth
Mammary epithelial cells are highly efficient secreting cells. This natural phenomenon has triggered research efforts to focus on using these cells to assist in the production of viable liquids. The application of this technology is nearly endless. If developed successfully, mammary epithelial …
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Metabolic regulation of mammalian cell growth and proliferation
Proliferation requires that cells acquire sufficient biomass to produce two daughter cells. To accomplish this, cells must utilize available nutrients to generate new components of cell mass, including proteins, lipids, and nucleic acids. In addition, cells must coordinate biosynthesis and …
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In search of: a membrane sialoglycoprotein cell growth inhibitor
Call number: LD2668 .T4 BIOL 1989 G55
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Acidosis Activated GPR68 Promotes Vascular Smooth Muscle Cell Growth
… the United States and worldwide. Localized extracellular acidosis has been theorized as a possible contributor to CVD pathogenesis, but its precise impact remains unclear. G protein coupled receptors (GPCRs) are seven transmembrane receptors that have wide-ranging functions in cardiovascular …
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Engineering cellular microenvironments for directed cell growth and migration
… enabled these systems to precisely control the cellular microenvironments and investigate cell behavior in vitro. This work aims at integration of advances in life sciences and microfabrication techniques to address fundamental biological questions underlying cellular behavior. We specifically …
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Precise single cell monitoring reveals principles of cell growth
Accumulation of mass is a fundamental cellular process that is associated with metabolism, signaling and regulation. Despite the wealth of knowledge in molecular processes the principles of growth in mammalian cells are poorly understood since growth has never been monitored with high precision. …
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Effect of silver nanoparticles on planktonic and biofilm cell growth
… applied individually depending on the microbial growth conditions. The research results demonstrated that the toxicity of Ag NPs was dependent on nanosilver particle sizes and related to of the concentration of intracellular reactive oxygen species (ROS). However, other metallic/oxide particles …
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Mechanisms of mTOR Signal Transduction Regulating Cell Growth and Differentiation
… mTOR is essential for miR-1 expression in C2C12 cells and in vivo in regenerating myofibers. It regulates the transcription of miR-1 through its upstream enhancers, and this regulation is at least partially mediated by the myogenic transcription factor MyoD. To delineate the pathway downstream of …
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Manipulating soft materials to direct cell growth in multiple dimensions
… applications—e.g. the study of non adherent cell types such as white blood cells. Recent studies, however, have shown that different cell types present important biological differences, in their differentiation, proliferation rates, migration and cell signaling, in two- versus …
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Measuring the effects of drugs on single cancer cell growth
… cancer biology. Conventional assays that study cell behavior after a drug intervention report the average response of a cell population which can mask the heterogeneity and dynamics of seemingly identical cells. Recently, many single-cell techniques have been developed, but there are currently …
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Phenomenological models in biological physics : cell growth and pluripotency maintenance
… and concentrations of molecules inside the cell, have evaded detection by the conventional experimental tools. How does one model a system whose crucial parameters are unknown? And even if we know all the parameters inside the cell, there is an increasing uneasiness among many researchers …
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Pyp3 Involvement in Mitotic Control and Cell Growth in Fission Yeast
… plays a crucial role in the regulation of the cell cycle. The kinases wee1+, mik1+ and the phosphatases cdc25+, pyp3+ play opposite roles in the regulation of p34cdc2 activity. In cells lacking wee1, tyrosine phosphorylation of p34cdc2 is carried out by Mik1; in cells lacking cdc25+, the …
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Microbial single-cell growth kinetics and heterogeneity in nutrient-limiting environments
… interactions. Cooperative interactions between cells, such as cross-feeding or division of labor, contribute to enhancing overall community fitness and increase the chance of cellular survival.<br /> An emerging trend in biotechnological research is to exploit the aspect of division of labor and …
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The Role of lAA in the Regulation of Plant Cell Growth
Batch cell suspension cultures of Acer pseudoplatanus L. provide an excellent system for studies of the hormonal regulation of cell growth. By using gas chromatography-mass spectrometry (GC-MS) for identification of the natural auxin, and spectrophotofluorimetry for a highly specific and sensitive …
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The Role of Sphingosine Kinase 2 in Cell Growth and Apoptosis
… (SIP). Whereas, SphKl stimulates cell growth and survival, it was found that when overexpressed in mouse NIH 3T3 fibroblasts SphK2 enhances caspase-dependent apoptosis in response to serum deprivation, independently of S1P receptors. Sequence analysis revealed that SphK2 contains a …
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Factors affecting bone cell growth and differentiation under differing culture conditions
Marrow stromal cell (MSC) differentiation into osteoblasts is an important part of the bone growth and remodeling process. This process can be exploited to help solve the problem of bone wound healing. Because of problems with bone grafts, implantation of biodegradable 3D scaffolds seeded with MSCs …
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