Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"cell generation"”.
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Limiting host-microbiota interactions to control intestinal inflammation
… and production of IgA. However, how Th17 cells contribute to intestinal immunity is still largely unknown. Our current studies indicate that Th17 cells play a critical role in controlling microbial contact with the epithelium. IgA is produced in large quantities and secreted into the …
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The role of TLR3- and MyD88-dependent signaling in the development of anti-West Nile virus adaptive immune responses induced by a vaccine candidate, RepliVAX WN.
… PAMPs and induces vigorous anti-WNV T and B cell responses. However, the innate mechanisms that link pattern recognition and development of vigorous antigen-specific T and B cell responses are not completely understood. Moreover, the roles of individual PRR signaling pathways in shaping T and …
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Generation and circuit development of zebrafish retinal horizontal cells
… a plethora of possible synaptic partners. Glial cells must also establish specialized associations with a number of neuronal structures including synapses and axons. In order to create a detailed understanding of how a neuron progresses through all of these stages of development, I have studied a …
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Cochlear hair cell regeneration from neonatal mouse supporting cells
… lower vertebrates, capable of spontaneous hair cell regeneration, mammals experience permanent sensorineural hearing loss following hair cell damage. Although low levels of hair cell regeneration have been demonstrated in the immature mammalian vestibular system, the cochlea has been thought to …
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Role of Nlc Cells in Murine Models of T Cell-Dependent Responses
NK cells are part of the innate immune system, yet they can also modulate the acquired immune response. Activated NK cells, for instance, can increase antigen specific IgG2a production in response to T independent responses, mostly through IFN-gamma secretion. Previous experiments examining the …
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Molecular Mechanisms Underlying The Transcriptional Regulation of T Helper 17 and Regulatory T Cells
… by orchestrating the function of other immune cell types. Naïve Th cells can differentiate into different effector subsets that are characterized by their cytokine profile and immune regulatory functions. These subsets include Th1, Th2, Th17, natural and inducible regulatory T cells (nTreg and …
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Forkhead Transcription Factors Foxp1 and Foxp4 Regulate T Cell Development and Function
Transcription factors regulate T cell fates at every stage of development and differentiation. Members of the FoxP family of Forkhead transcription factors are essential for normal T lineage development; Foxp3 is required for regulatory T cell generation and function, and Foxp1 is necessary for the …
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Erk1 and Erk2 in hematopoiesis, mast cell function, and the management of Nf1-associated leukemia and tumors
… of heterozygosity (LOH) in myeloid progenitor cells sufficiently engenders leukemogenesis, plexiform neurofibroma formation depends on LOH in Schwann cells and Nf1 heterozygosity in the hematopoietic system. Specifically, recruited Nf1+/- mast cells accelerate tumorigenesis through secreted …
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Novel Characteristics of Murine Bone Marrow-Derived Macrophages and Human Macrophage-Like Cells
… of macrophages derived from bone marrow stem cells. In study 1, treatment of activated mouse bone marrow-derived macrophages (BMM) with either catecholamine synthesis inhibitors (α-methyl-para-tyrosine and fusaric acid) or the β2 adrenergic receptor antagonist ICI 118,551 demonstrated that BMM …
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Advancing T Cell–Based Immunotherapies: Identification of Tumor-Specific T Cell Receptor Targets and Mechanisms of Resistance in Solid Tumors
<p>Cancer immunotherapies, such as adoptive cell therapy, have transformed cancer treatment by eliciting durable immune responses. While adoptive cell therapy has demonstrated remarkable success in hematologic malignancies and several solid tumors, most patients with solid tumors either fail to …
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Anti-cancer effects of aqueous extracts of Dodonaea Viscosa on Burkitt lymphoma
… is Burkitt lymphoma (BL), a highly aggressive B-cell-derived malignancy, which develops predominantly in HIV-infected individuals. Many cancer patients, especially those from rural communities, use traditional medicine (TM) as an alternative to chemotherapy. While conventional treatments have …
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Generating hair follicle inductive dermal papillae cells from adipose derived mesenchymal stem cells
… generating de novo folliculogenesis from human cells has yet to be accomplished. Existing models rely on combining 'inductive’ dermal and 'receptive’ epithelial components and placing them within a suitable model. Epithelial cells are easily obtainable from skin biopsies therefore obtaining …
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Characterisation of factors that regulate homologous recombination and antigenic variation in Trypanosoma brucei
… Surface Glycoprotein (VSG) expressed on the cell surface. Such reactions can occur at very high rates (~10-3 switches/cell/generation) and occur primarily by the recombination of VSG genes, selected from an enormous silent archive, into specialised expression sites. It has been previously …
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Studies on the Metabolism of Plant Cells in Tissue Culture
1. A tobacco cell-suspension tissue culture system derived from pith cells of Nicotiana tabacum L. var Wisconsin 38 was established. This system was used to study methods of purifying nucleic acids, phosphate ester and nucleic acid metabolism in cells subjected to nutritional shifts, and problems …