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Showing 1 to 13 of 13 for “"cell force"”.
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Single Cell Force Platforms to Link Force-ECM Coupling in Pathophysiology
Migratory cells in vivo move within a predominantly fibrous microenvironment through the action of forces. These dynamic interactions facilitate mechanosensing, critical to fundamental biological processes in pathophysiology. Naturally, the field of mechanobiology has evolved over the past several …
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Technology assessment and feasibility study of high-throughput single cell force spectroscopy
In the last decade, the field of single cell mechanics has emerged with the development of high resolution experimental and computational methods, providing significant amount of information about individual cells instead of the averaged characteristics provided by classical assays from large …
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Development of a novel cell traction force transducer based on cholesteryl ester liquid crystals. Characterisation, quantification and evaluation of a cholesteryl ester liquid crystal based single cell force transducer system.
In biomechano-transducing, cellular generated tension can be measured by soft substrates based on polymers but these techniques are limited either by spatial resolution or ability to detect localised cell traction forces (CTF) due to their non-linear viscous behaviour under shear rates. A newly …
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Analyzing Interactions Between Cells And Extracellular Matrix By Atomic Force Microscopy
Interactions of cells with the extracellular matrix (ECM) have important roles in various physiological and pathological processes, including tissue morphogenesis during embryonic development, wound healing and tumor invasion. Although most of the proteins involved in cell-ECM interactions have …
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Development of an in vitro model of contraction by fibroblasts
… conditions which promote tissue regeneration. A cell force monitor (CFM) was designed and constructed to measure quantitatively the contraction of a highly-porous, collagen-GAG matrix by fibroblasts. Using this device, contractile force, displacement, and kinetics were compared for different …
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Force regulation in contractile cells by chemical and mechanical signaling
… signals can promote disease states by altering force generation. It is cru- cial that we understand how these signals affect force generation and the implication of that force in health and disease. We approach this by investigating cells from two types of tissues: heart tissue cells and …
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An investigation into cellular attachment and contraction in collagen-GAG scaffolds with characterized pore sizes
… of dermal fibroblasts. An updated design of the Cell Force Monitor (CFM) was used to quantify bulk cellular contractile behavior in seeded scaffolds. The effect of scaffold geometry on fibroblast contractile behavior was also investigated with the CFM. Results show that cellular seeding methods …
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Chemomechanics at the cell-material interface : measurements and implications of forced molecular unbinding
… and mechanically characterized materials and cells that are relevant to microvascular physiology and pathology. In particular, the mechanical characterization of cell surface structure and force generation are realized via various atomic force microscopy (AFM) imaging techniques including AFM …
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Development of a Novel Single-Cell Attachment and Spreading Platform Utilizing Fused-Fiber Nanonets
Initial attachment to the extracellular matrix (ECM) and consequent spreading is a necessary process in the cell cycle of which little is known. Cell spreading has been well-recognized in 2D systems, however, the native fibrous ECM presents cells with 3D biophysical cues. Thus, using suspended …
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Cell-Fiber Interactions: A New Route to Mechano-Biological Investigations in Developmental and Disease Biology
Cells in the body interact with a predominantly fibrous microenvironment and constantly adapt to changes in their neighboring physiochemical environment, which has implications in developmental and disease biology. A myriad of in vitro platforms including 2D flat and 3D gel substrates with and …
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Hierarchical Assembly of Polymeric Nanofibers for Advanced Material Applications
… diverse fields, such as tissue engineering, fuel cells, photonics and sensors. For these applications, manufacturing aligned polymer nanofibers with precisely controlled morphology and well characterized mechanical properties in a bottom up configuration is essential. In this work, we developed an …
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Effects of Wire Material, Deflection, and Interbracket Distance on Burstone Bracket Geometry Force Systems
… six-geometries: the moment dissociation point (force system with no moment on the lesser angled bracket), which may or may not occur at the classically defined geometry IV. Materials and Methods. A six-degree of freedom load cell was used to measure the force systems in different combinations of …
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Comparative Hydrodynamic Testing of Small Scale Models
Early in the ship design process, naval architects must often evaluate and compare multiple hull forms for a specific set of requirements. Analytical tools are useful for quick comparisons, but they usually specialize in a specific hull type and are therefore not adequate for comparing dissimilar …