Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 470 for “"cell fate"”.
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Redox Regulation of Cell Fate
To further study the intracellular redox environment, two novel technologies were developed: first, a conductive substrate cell culture system to control the intracellular redox environment via electrical potentials; and second, a FRET (fluorescence resonance energy transfer)-based redox biosensor …
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Systems Engineering of Stem Cell Fate
Recent advances in the derivation of functional cells from pluripotent stem cells have raised hope for cell therapy to treat liver ailments. They have enhanced the prospects of developing reliable in vitro models for liver diseases and drug toxicity screening. A differentiation protocol mimicking …
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The physics of cell-fate choice
Multicellular organisms are composed of many different cell types. All such cells arise from a single cell--- the zygote--- and acquire the various cell fates seen in adult organisms. The different cell types are characterized by distinct, cell-fate-specific gene expression patterns. Cells of …
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Hematopoiesis: Functional Insights by Cell Fate Conversion
Blood cell formation, or hematopoiesis, is maintained by rare hematopoietic stem cells (HSCs) residing in the bone marrow (BM). HSCs may self-renew (the process whereby HSCs replicate to produce new HSCs) to preserve their own numbers, as well as initiate a highly coordinated hierarchical …
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Engineering hydrogel environments to direct cell fate
… in recent years as a means to investigate cellular level processes. An area that has shown promising application of hydrogel materials has been in the study of stem cell development. Proven that the microenvironment of the stem cell plays a critical role in its development, hydrogels can …
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Cell Fate Decisions in the Developing Lung
… multipotent progenitor population of epithelial cells resides in the distal tip of the developing lung (Nikolić and Rawlins, 2017) and is capable of differentiating into both bronchiolar and alveolar cells. Clarifying which tip cells differentiate to form the different lung compartments, and what …
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The guardians of cell fate: protective mechanisms that ensure proper cell fate and patterning during imaginal disc regeneration in drosophila
… tissue must replace lost structures with cells of the proper identity and pattern in order to restore function. This thesis will describe two major insights into how patterning and cell fate is maintained and restored during the late phases of regeneration in the wing imaginal disc of …
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Feedback Regulation of Human Hematopoietic Stem Cell Fate
Hematopoietic stem cell (HSC) fate decisions at least in part determine cellular composition of the hematopoietic system. It is known that differentiated blood cells produce ligands that act on HSCs to influence HSC fate. However, fundamentals underlying the feedback regulation of HSC fate are …
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Building a Methodological Framework for Cell Fate Engineering
Cell fate engineering has become an area of intense research in the last fifteen years. A useful framework of cell fate engineering should include three pillars: the discovery of new cell fate-reprogramming cocktails of factors, the evaluation of engineered cells, and the revelation of underlying …
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Cell Fate Decisions in the Early Mammalian Embryo
… from the totipotent zygote via two successive cell fate decisions in the appropriate sequence, position and proportion, to generate a blastocyst capable of implantation and further development. In mammals this process has long been thought to be regulative, with cell-cell interactions flexibly …
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Metabolic and genetic factors guiding hematopoietic cell fate
… development requires precise control over cellular identity, and a wide range of diseases is characterized by altered differentiation states. Understanding the environmental factors that interplay with gene expression networks to regulate cell state holds immense potential for both basic …
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Cell fate reprogramming using transcription factor feedback overexpression
Recent advances in stem cell research has demonstrated that the fate of a terminally differentiated cell can be reverted back to pluripotency. The ability to reprogram a differentiated cell back to its undifferentiated, pluripotent state would be a significant breakthrough for regenerative …
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Functional Genomics Based Interrogation of Cell-Fate Determination Pathways
… RNA interference screening in murine cultured cells, I established previously unknown associations between these signaling pathways and genes linked to developmental malformations, diseases of premature tissue degeneration, and cancer. I identified functions in both pathways for the …
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The transcriptional regulation of skeletal muscle progenitor cell fate
… was able to induce the entire myogenic program. Cells overexpressing Sox15 show elevated levels of genes that inhibit differentiation and promote proliferation, which coincides with the lack of progression past the muscle precursor stage. These results demonstrate that Sox15 and Sox7 have …
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Transcription factor Pax6 protects mouse cortical cell fate specification
… composed of two main types of neuron. Principal cells (PCs) are glutamatergic and use glutamate as the main neurotransmitter. Interneurons are mostly GABAergic and use GABA as their main neurotransmitter. PCs are the output units of the cortex and comprise ~80-85% of the mouse cortex. …
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The role of translation in keratinocyte cell fate determination.
… by a population of proliferating progenitor cells localised in the basal layer of the tissue. While progenitor cells normally remain in the basal layer throughout their lifetime, differentiating cells move up the tissue and are eventually shed off, helping to maintain tissue homeostasis. …
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Identifying regulators of neural stem cell fate and tumourigenesis
The proliferation of neural stem cells (NSCs) must be regulated precisely in order to generate a functional nervous system. Mis-regulated NSC division can lead to the inadequate production of differentiated progeny or to ectopic NSCs and tumour formation. As such, genes that promote the …
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Investigating factors governing cell fate decisions in respiratory epithelium
… embryonic development require tightly regulated cell fate decisions. This regulation takes the form of complex transcription factor and signalling cascades, much of which are unknown, particularly in human lung development. Multiciliogenesis describes the process of specification/differentiation …
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Determination of cell fate selection during phage lambda Infection
… of Escherichia coli can result in distinct cell fate outcomes: for example, some cells lyse while others survive as lysogens. A quantitative molecular model of lambda infection supports the hypothesis that spontaneous differences in the timing of individual molecular events during lambda …
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