Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 92 for “"cell expansion"”.
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Neural stem cell expansion rejuvenates learning strategies and memory throughout life
Der Hippocampus ist ein Hirnareal welches fundamental für die Generierung von bewussten Erinnerungen und für die Etablierung von flexiblen Beziehungen zwischen kontextuellen Repräsentationen ist. Hippocampale Fehlfunktion während des Alterns wurde als ein Schlüsselfaktor für den kognitiven …
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Membrane Bound Il21 Promotes Natural Killer Cell Expansion Through Mir 124-3P Mediated Regulation
<p>Natural Killer (NK) cells are cells of the innate immune system that act as first line of defense against viral infections and participate in tumor immune surveillance. NK cells do not cause graft versus host disease (GvHD), or require prior antigen exposure to exert anti-tumor activity, hence …
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Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Low-dose IL-2 for T-regulatory cell expansion after alemtuzumab therapy in relapsing-remitting multiple sclerosis
T-regulatory cells (Tregs) are vital for the prevention of autoimmunity, and they require interleukin-2 to function optimally. Their expression of the high-affinity IL-2 receptor, containing the CD25 subunit, renders them 10-fold more sensitive to IL-2 than effector cells (Teffs). Low-dose IL-2 …
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Insulin-Like Growth Factor-Binding Protein 2 Supports Hematopoietic Stem Cell Expansion: From In Vitro to In Vivo
Successful hematopoietic stem cell (HSC) transplantation is often limited by the numbers of HSCs, and robust methods to expand HSCs ex vivo are needed. We previously showed that angiopoietin-like proteins (Angptls), a group of growth factors isolated from a fetal liver HSC supportive cell …
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Comparison of HIV-1 specific T cell immunity in the female genital tract and blood of HIV-infected women : impact of in vitro T cell expansion on HIV-specific T cell specificity, maturational status and functional complexity
This study shows that HIV-specific cervical T cells can be isolated by cytobrushing and in vitro polyclonal expansion is a useful approach to increase the number of T cells available from mucosal sites. Dynal beads (1:1) in the presence of IL-2, IL-7 and IL-15 resulted in the best yields of …
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Regulation of Development of the Storage Root of Sugarbeet
Small cells, found in the cambial regions of the sugarbeet storage root are relatively more efficient at accumulating sucrose than the large cells of the parenchymatous zones (Milford, 1973). As part of a wider investigation into the regulation of cambial activity in sugarbeet, the role of the …
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Sensory Neurons Initiate Tuft Cell-Dependent Sinonasal Allergic Inflammation via Substance P
… precise role and potential interactions of tuft cells with trigeminal sinonasal neurons in the context of allergic disease remain largely unexplored and unclear. This study investigated the impact of intranasal administration of house dust mite or fungal allergens on these cells and sought to …
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Notch signaling and cell cycle inhibitor regulation in pituitary organogenesis
The pituitary is plastic organ whose hormone cell number can fluctuate depending on physiologic need. Alterations in pituitary cell expansion can lead to disorders such as pituitary hyperplasia or tumors, which have a high prevalence in the human population. Precise control of cell cycle …
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Notochord morphogenesis as a mechanical driver of embryo axis elongation
… shape in order to transform from a collection of cells into a functioning organism with a specialised body morphology. A key step in this process is the elongation of the head-to-tail, or anterior-posterior (AP) embryonic axis. For axis elongation to occur, multiple tissues must deform …
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The Role of the Ubiquitin-Proteasome Pathway During Xylem Differentiation in <I>Zinnia elegans</I> Mesophyll Cells and <I>Arabidopsis thaliana</I>
… was conducted in <I>Zinnia</I> mesophyll cell cultures to examine potential differences between differentiating cells of tracheary element (TE) cultures and non-differentiating cells of control cultures. The pathway is highly active throughout development of differentiating TEs, a …
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Identification of growth-related tonoplast proteins in Arabidopsis thaliana
… leaf growth can be reduced to two processes, cell division and cell expansion, accompanied by expansion of their surrounding cell walls. The vacuole, as being the largest compartment of the plant cell, plays a major role in controlling the water balance of the plant. This is achieved by …
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Development and Validation of Large-Sized Engineered Cartilage Constructs in Full –Thickness Chondral Defects in a Rabbit Model
… however, rely on the need for a large number of cells, requiring substantial harvesting of donor tissue or a separate cell expansion phase. As routine cell expansion methods tend to elicit negative effects on cell function, the following study describes an approach to generate large-sized …
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Rgs16 is a Pancreatic Reporter of Chronic Hyperglycemia in Diabetes
… results from pancreatic insulin producing beta cell loss due to autoimmune attack and consequent insulin insufficiency, whereas type 2 diabetes occurs as a result of somatic cell insulin resistance under metabolic stress. Therapies include insulin supplementation for type 1 diabetics and diet …
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Physiological, hormonal and metabolic alterations caused by selenium in rice seedlings
… of transcripts encoding auxin transport and cell expansion proteins. Moreover, SeMet led to increased respiration, which was positively correlated with organic acids consumption, but negatively with sugars consumption, thereby decreasing seedling growth. In contrast with SeMet treatment, L- …
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The Evolution and Development of Nectar Spurs
… A morphological characterisation (recording cell number and cell length across a range of developmental stages) was performed to determine whether the difference is due to cell expansion or cell division. We found that primarily cell number and therefore cell division drives an increase in …
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THE ROLE OF TYPE I INTERFERONS IN THE HOST CD8+ T CELL RESPONSE DURING GAMMAHERPESVIRUS INFECTION
… or treatment of EBV-associated cancers. CD8+ T cells are crucial to the control of both lytic and latent gammaherpesvirus infection, as demonstrated in the well-established murine model of EBV, murine herpesvirus 68 (MHV68). Type I interferons (type I IFN) also suppress lytic and latent MHV68 …
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The Function of PTPN22 and the Autoimmune Risk Variant LypW in Immune Responses to Vaccination
High-affinity antibody production, T cell activation, and Interferon upregulation all contribute to protective immunity that occurs in humans following influenza immunization. Hematopoietic cell-specific PTPN22 encodes Lymphoid Phosphatase (Lyp), which regulates lymphocyte antigen receptor and …
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The Role of the PD-1 Immunoreceptor in Pregnancy
… interaction with its ligand, B7-H1, prevents T cell activation. B7-H1 is expressed in the human placenta throughout gestation, therefore we studied the role of the PD-1 receptor in modulating maternal T cells during pregnancy. PD-1 is preferentially expressed on human decidual T cells and B7-H1 …
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Functional analysis of selected DOF transcription factors in the model plant Arabidopsis thaliana
… et al., 2007). Finally OBP1 regulates both cell proliferation and cell expansion. It was shown that OBP1 controls cell cycle activity by directly targeting the expression of core cell cycle genes (CYCD3;3 and KRP7), other TFs and components of the replication machinery. Evidence for OBP1 …
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