Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"cell excitability"”.
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ADENOSINE SYSTEM DYNAMICS AND SK CHANNELS MODULATE BASOLATERAL AMYGDALA PYRAMIDAL CELL EXCITABILITY: IMPLICATIONS FOR ANXIETY DISORDERS AND COMORBID ETHANOL ABUSE
Alcohol use disorders (AUDs) impart serious social and economic costs on society. For example, nearly 1 in 18 Americans abuses or is addicted to alcohol, contributing nearly $234 billion per year in socioeconomic costs. Despite this, effective pharmacological treatments remain elusive. To aid in …
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Adenosinergic modulation of hippocampal gamma oscillations: from single cell to whole animal
… vitro. Sharp electrode current clamp and whole-cell voltage clamp experiments showed that \(A_1\)-receptor activation hyperpolarised resting membrane potential, reduced firing rate and EPSP amplitude and shifted the IPSC reversal potential to more negative potentials. Blocking \(A_1\)-receptors …
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Postnatal development of brainstem cholinergic inputs to the dorsal lateral geniculate nucleus of the domesticated ferret, Mustela putorius furo
… Because of its dependence on postsynaptic (relay cell) activity, sub lamination may be influenced by extra retinal inputs which alter relay cell excitability. We have examined the postnatal development of cholinergic brainstem inputs to the dLGN to determine whether these inputs arrive in time to …
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Evaluation of the Functional Roles of TRPA1 Homologs, Painless and dTRPA1, in Chemical Nociception in Drosophila
… a lack of colocalization in the adult CNS. Cell populations were further defined by the identification of cell specific markers. Subsets of <italic>painless</italic>- and <italic>dTRPA1</italic>-expressing cells coexpress the neuropeptides, DH<sub>31</sub> and leucokinin, respectively. …
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Physiological Effects of Estradiol in the Mouse Hippocampal Formation
… of spine synapse density and hippocampal cell excitability. Future studies should aim to understand the specific role of Akt and BDNF in estradiol modulation of hippocampal function and behavior.</p>
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Protein Phosphatase Inhibitor-1 and Cdk5: Of Molecules and Memory
… functions of the hippocampus. Using a whole-cell patch clamp approach, we also attempted to identify electrical properties of dentate granule cells that might be affected by Cdk5-dependent phosphorylation of inhibitor-1. Most promising among the results was a reduction in the ability of …
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Modulation of Signal Transduction in the Nervous System by Protein Phosphorylation
… transduction, the process by which an extracellular signal is translated into an intracellular message, underlies all brain function. This thesis examines the role of protein phosphorylation in mediating three different molecular mechanisms by which neurotransmitter receptors transduce their …
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Elucidating the reversibility of ataxia
… motor deficiencies as well as reduced Purkinje cell firing frequency followed by dendritic tree degeneration and cell death. The aims of this study were to evaluate progression of Purkinje cell degeneration following loss of b-III spectrin function and determine whether the reintroduction of …