Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"cell encapsulation"”.
-
Hydrogel cell encapsulation for tissue engineering
… In many tissue engineering approaches, cells seeded within 3D porous structures are expected to remodel into tissue-like structures. Despite significant progress, difficulties in lack of control over tissue architecture as well as vascularization continue to limit the efficacy of …
-
Study of drug delivery and cell encapsulation using biocompatible hydrogel
… particles encapsulating biomolecules or living cells are becoming an attractive means to mediate drug delivery or facilitate cell-based treatment of diseases. These particles are capable of maintaining drug stability/cell viability and providing specific drug release profiles. The selection of …
-
Characterization of pattern recognition receptor responses against materials for cell encapsulation
… the need for systemic immunosuppressive therapy. Cell encapsulation is an attractive technology to enable donor cell transplantation, but clinical success has remained elusive due to immunological responses to the encapsulated materials. Alginate is the leading material for the microencapsulation …
-
A NOVEL DROPLET-BASED PLATFORM FOR TUMOR SINGLE-CELL ENCAPSULATION AND METASTATIC MULTICELLULAR CLUSTER MODELLING
… mortality, with circulating tumour cell clusters exhibiting higher metastatic potential than single cells. This thesis introduces a microfluidic-based platform for the controlled generation and culturing of single cells and multicellular CTC cluster models within physiologically …
-
Use of poly vinyl alcohol (PVA) cryogelation for tissue engineering: composites, scaffold formation and cell encapsulation
… However PVA cryogels are not suitable for cell attachment and proliferation alone. This can be overcome by the development of composite cryogels. Moreover, cryogelation provides a unique opportunity for encapsulation and storage of cells in one-step; if the correct composite structure and …
-
Numerical Study on Droplet Formation and Cell Encapsulation Process in a Micro T-junction via Lattice Boltzmann Method
… reaction media for the chemical manipulation of cells. The droplet formation and cell encapsulation process involves multiphase flows along with coupled cell membrane-fluid mechanics. In this study, the droplet formation behavior in a T-shaped micro-fluidic device is simulated using two- and …
-
Collagen and hyaluronic acid interpenetrating polymer networks for tissue engineering
… fluorescent techniques. The IPNs are used for cell encapsulation and have the potential to be used for surface cell culture. The mechanical properties can be adjusted to match those of cardiac tissue. Thus, when combined with the properties of biocompatibility, viable cell encapsulation, and …
-
A Microfluidic Device for Transfection of Mammalian Cells Using Adjustable Shear Stress
… a microfluidic device capable of transfecting cells by applying shear stress to cause temporary membrane damage. The advantage of this physical method of transfection is the possibility of incorporating large molecules that cannot be inserted with more traditional chemical transfection methods, …
-
Stop-flow lithography and its application to graphical encoding
… with direct SFL fabrication are incorporated by encapsulation; on the other hand, this capability applies to single cell encapsulation and graphical encoding. This powerful tool facilitates fabrication of complex building blocks and potentially promotes self-assembly and application of colloids. …
-
Overcoming Diffusion Limitations in Encapsulated Cell Therapy for Type 1 Diabetes
… requires immune suppression, but islet encapsulation would eliminate this requirement. A hydrogel encapsulation barrier, made from alginate, physically shields transplanted cells from rejection by the immune system. However, encapsulated islets completely rely on diffusion for nutrient …
-
Mask Projection Microstereolithography 3D Printing of Gelatin Methacrylate
… synthesis, tunable mechanical properties, and cellular response. Biotechnology applications utilizing GelMA have ranged from developing cell-laden hydrogel networks to cell encapsulation and additive manufacturing (3D printing). However, extrusion based 3D printing is the most common technique …
-
Microfluidic Techniques for Protein Detection and Manipulation
… serve as optimal vehicles for drug delivery or cell encapsulation purposes.
-
Development of an electronic aerosol atomisation system for generating three-dimensional (3D) cells in microencapsulations and microtissues characterisation
Cell encapsulation is a micro technology widely applied in cell and tissue engineering, tissue transplantation and regenerative medicine. Various techniques had been developed for microencapsulation of cells but these techniques presented threat to the cells due to the harsh or chemical treatment …
-
Pheochromocytoma-induced cardiomyopathy : a model of synergistic effects of multifactorial tumor secretions
… by catecholamine-secreting pheochromocytoma cells. Pheochromocytomas are widely believed to induce cardiomyopathy via hypersecretion of catecholamines including norepinephrine (NE). NE can have direct cardiomyocyte toxicity and can stimulate myocardial remodeling secondary to the induction of …
-
Environmental Analysis at the Nanoscale: From Sensor Development to Full Scale Data Processing
… (SERS). Shifting the SERS workflow from a cell-to-cell mapping routine to the mapping of tens to hundreds of cells demanded the development of an automated processing tool to perform basic SERS analyses such as baseline correction, peak feature selection, and SERS map generation. The …
-
Elucidating Purinergic and Pro-inflammatory Signaling Mechanisms in Breast Cancer
Integration of cancer cell-intrinsic and extrinsic signaling cues supports the emergence of tissue-specific microenvironments that stimulate neoplastic transformation and malignancy. Tumor-acquired hallmarks that maintain functional plasticity frequently result from intrinsic genomic aberrations …
-
Microfluidics for Cell Culture and Single Cell Assays
Elucidating molecular processes that govern cell function is paramount in forming a basis for understanding human health and treating disease. Research is presently limited by investigating in bulk, where information on critical subsets of cells is lost through averaging across an entire …
-
Collagen scaffolds and injectable biopolymer gels for cardiac tissue engineering
… scaffolds have begun to shown promise for cell delivery for cardiac tissue engineering. Although various polymers and material forms have been explored, there is a need for: injectable gels that meet certain design specifications; a more indepth characterization of the scaffold properties; …
-
Enhancing Chondrocyte Biosynthetic Activities: Harnessing the Power of Loading-Induced Evolved Temperature
… approach, we commence by probing into the cellular effects of temperature increase during cyclic loading, unmasking its profound significance in the realm of cartilage mechanobiology. The research findings provide robust evidence substantiating that the synergy between mechanical signals …
-
Encapsulation as a 3D model for human embryonic stem cell propagation and differentiation
… disease caused by the destruction of the beta cells of the pancreas. Current treatments for are whole pancreas or islet transplantation, which is limited by scarcity of cadaveric pancreata. Therefore, developing a cell replacement therapy with renewable sources of surrogate beta cells is …
Page 1 of 2