Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"cell division cycle"”.
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Intracytoplasmic Membrane Synthesis During the Cell Division Cycle of Rhodopseudomonas Sphaeroides
Made available in DSpace on 2014-12-14T07:14:48Z (GMT). No. of bitstreams: 1 7915349.pdf: 7080249 bytes, checksum: 6c279d9477695fda05efce3277d55dea (MD5) Previous issue date: 1979
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DNA damage responses in the context of the cell division cycle
… response (DDR) in the context of three different cellular scenarios: DNA damage signalling in response to double-strand breaks during mitosis, coordination of DNA replication with DNA damage responses by regulation of the GINS complex, and checkpoint activation by the prototypical checkpoint …
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Analysis of markers of cell division cycle, apoptosis and autophagy flux in glioblastoma
… This study aimed to investigate markers of cell division cycle, apoptosis and autophagy flux in an attempt to identify biomarkers with prognostic and/or predictive significance. The cell cycle markers studied included: Mcm2, expressed throughout the cell cycle; Cyclin A, an S-phase cyclin; …
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Quantitative Modeling of the Molecular Mechanism Controlling the Asymmetric Cell Division Cycle in <i>Caulobacter crescentus</i>
… model organism for studying regulation of cell growth, division and differentiation in prokaryotes. <i>C. crescentus</i> undergoes asymmetric division producing two progeny cells with identical genome but different developmental programs: the "swarmer" cell is flagellated and motile, and …
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Cell cycle parameters and sweet corn emergence and seedling vigor
… used to investigate the contribution of seedling cell division to emergence and seedling growth. Variation among genotypes was observed for all of the cell division cycle phases which include G1, S, and G2. The S phase, when cells are undergoing DNA replication, showed the closest association to …
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Development of less toxic analogues of fascaplysin as novel therapeutic agents for the treatment of cancer
… All of these aberrations can cause deregulated cell growth, resulting in tumour formation. Therefore, a small synthetic molecule or a natural product that specifically and potently inhibits the kinase activity of Cdk4 in vitro and prevents cell growth and tumour volume in vivo could be of …
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Role of CDC25 Phosphatases in Non-Melanoma Skin Cancer
… (UV). UV-induced DNA damage activates cell cycle checkpoints through a mechanism involving degradation of the cyclin dependent kinase activators, the cell division cycle 25 (CDC25) phosphatases, and also activates Erbb family members indirectly through reactive oxygen species …
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High precision mass-based assay to examine growth regulation of the cell cycle
Studying biophysical properties of cells can provide insight into the metabolic mechanisms and regulation of cell cycle processes. Though size is considered to be a fundamental property of cell state, its measurement on a single-cell basis with high-resolution has been elusive primarily due to …
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Molecular biogeochemistry of modern and ancient marine microbes
… of the Prochlorococcus proteome over the diel cell-division cycle reveals that protein abundances are distinct from transcript-level dynamics, and that small temporal shifts in enzyme levels can redirect metabolic fluxes. This thesis illustrates how molecular techniques can contribute to a …
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The Role of CDCA7 in Akt-mediated Myc-Dependent Apoptosis and Proliferation
CDCA7, or cell division cycle associated protein A7, was described in 2001 by Prescott and colleagues as a target of Myc-dependent transcriptional regulation (Prescott et al., 2001). We have identified CDCA7 as associating with the transcription factor Myc and is the target of phosphorylation by …
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Stimulus-Mitosis Coupling in the Rat Thymic Lymphocyte
Various extracellular stimuli provoke the entry of normally quiescent rat thymic lymphocytes into the cell division cycle. This study has investigated the events which follow signal presentation and which culminate in cell cycle entry. The initial experiments examined mitotic activity in cultured …
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Induction of Cellular Induction Senescence by BTG2_(TIS21/PC3) Gene in Huh7 Hepatocellular carcinoma Cells
… regulates G1-S and G2-M progressions of cell division cycle through the inhibition of G1 phase cyclin biosynthesis, and the delayed degradations of cycin B1 and cyclin A, respectively. Therefore, we earlier suggested that TIS21 might play a role as a pan-cell cycle regulator and an …
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Molecular Biogeochemistry of modern and ancient marine microbes
… of the Prochlorococcus proteome over the diel cell-division cycle reveals that protein abundances are distinct from transcript-level dynamics, and that small temporal shifts in enzyme levels can redirect metabolic fluxes. This thesis illustrates how molecular techniques can contribute to a …
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Computational Techniques for the Analysis of Large Scale Biological Systems
… problems, with applications to the yeast cell division cycle, and to the RNA-Sequencing of the yellow fever mosquito. Cell cycle system evolves stochastic effects when there are a small number of molecules react each other. Consequently, the stochastic effects of the cell cycle are …
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Characterizing the contribution of the LXCXE binding cleft to pRB-mediated genome stability and tumor suppression
… mitotic chromosomes are critical processes for cellular propagation and if compromised, can lead to genomic instability. Genomic instability is known to be an active contributor to tumorigenesis, rather than being a by-product of malignant progression. The retinoblastoma protein (pRB) is the …
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Regulation and functions of Cdc14 in mitotic exit in Saccharomyces cerevisiae
… to ensure the accurate formation of two daughter cells from one parental cell, the series of events that comprise the mitotic cell division cycle must be carefully regulated. Much of this regulation affects the transitions between the stages of the cell cycle, which are controlled by proteins …
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Validating the WD Repeat Protein CDC40 as a Potential Therapeutic Target for Lung Cancer
… suggested that the pre-mRNA splicing factor Cell Division Cycle 40 (CDC40) is essential for lung cancer cell survival. In this study, I characterized the effects of CDC40 knockdown in a panel of lung cancer cells. I show that CDC40 knockdown induced cell cycle defects resulting in strong …
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