Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"cell delivery"”.
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Keratin Microparticles for Drug and Cell Delivery
… of these hydrogels are an intriguing delivery vehicle for drugs and cellular payloads for tissue engineering purposes due to the ability to exploit size, surface area, loading potential and importantly, non-invasive delivery (i.e. injection) of cells and biologics. Here we examine the …
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A microfabricated 3-D stem cell delivery scaffold for retinal regenerative therapy
… result in the degeneration of the photoreceptor cells and can ultimately lead to blindness in patients. There is currently no cure for AMD or RP, and only a few methods exist for slowing the progression of these diseases. Although there has been much recent headway in cell replacement therapy to …
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Evaluation of Prototype Cell Delivery Catheters Using Agarose Gel and Cell Culture Experiments
… brain barrier constitutes a major obstacle to delivery of therapeutic agents administered systemically for treating these disorders. Intracranial drug delivery provides a novel way of bypassing the blood brain barrier and achieving high concentration of therapeutic agents in the brain while …
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Biodegradable Hydrogel Composites for Growth Factor and Stem Cell Delivery in Osteochondral Tissue Engineering
… develop hydrogel composites as growth factor and cell delivery vehicles to study the regeneration of osteochondral tissue. First, we investigated the release of growth factors from acellular hydrogel composites containing gelatin microparticles (GMPs) to stimulate the repair of cartilage tissue in …
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Magnetic Steering to Save Sight: Trabecular Meshwork Cell Therapy as a Treatment for Primary Open Angle Glaucoma
… loss of vision by damaging retinal ganglion cells. The major risk factor for POAG is high intraocular pressure (IOP). Current clinical treatments for POAG aim to reduce IOP, but they often have low success rates. The trabecular meshwork (TM) is a key regulator of IOP and has been shown to …
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Ex-Vivo Injection of Biomaterial Biologics for Treatment of Osteonecrosis
… to bone produces osteonecrosis, characterized by cell necrosis and tissue destruction. This necrotic microenvironment induces chronic inflammation, poor bone regeneration, joint deformity, osteoarthritis, and potentially a total joint replacement. One potential treatment is to remove necrotic …
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Use of Echogenic Immunoliposomes For Delivery of Both Drug and Stem Cells For Inhibition of Atheroma Progression
<p><strong>Use of Echogenic Immunoliposomes for Delivery of both Drug and Stem Cells for Inhibition of Atheroma Progression </strong></p> <p>By Ali K. Naji B.S. Advisor: Dr. Melvin E. Klegerman PhD</p> <p><strong>Background</strong> and significance: Echogenic liposomes can be used as drug and cell …
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Characterization and Assessment of Lung and Bone Marrow Derived Endothelial Cells and their Bone Regenerative Potential
… as an effective therapy. This therapy uses stem cells to aid in tissue regeneration. Endothelial progenitor cells (EPCs) were selected due to their ability to form tube-like networks in vitro. EPCs were isolated from murine bone marrow and lung tissue. We tested EPC’s tube forming, proliferative, …
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Chondrogenesis of Stem/Progenitor Cells by Chemotaxis Using Novel Cell Homing Systems
… for cartilage tissue engineering involves cell transplantation with or without cytokine delivery, biomaterial scaffolds, bioreactors, applied mechanical stimulation and altered oxygen tension. Despite its scientific merit, cell delivery faces drawbacks including scarce cell availability, …
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The multiple migratory mechanisms of systemically infused mesenchymal stem cells to sites of inflammation
Systemically infused mesenchymal stem cells (MSC) are being explored for their immunomodulatory therapeutic potential in multiple inflammatory pathologies. This therapeutic potential has been associated with the ability of MSC to accumulate at sites of inflammation following infusion. However, …
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Extracellular matrix stiffness and geometry: The impact on static and dynamic cellular systems in vitro and the treatment of tissue ischemia
Biologically relevant cell culture assays that can be adapted for high-throughput screening are very important for biopharmaceutical industry. Cellular material for such applications can represent static cultures that do not change over time, or dynamic (i.e. transformational) cultures based on …
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Biomaterials for the extracellular control of mesenchymal stem cell pro-angiogenic potential
With the prevalence of ischemic heart disease, cell based treatments have emerged as promising therapeutic options to promote angiogenesis. The use of adult mesenchymal stem cells (MSCs), particularly, is an area of active investigation. However, clinical efficacy has proved variable, likely on …
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Advances in Bone Tissue Engineering
… these limitations. By combining bone forming cells, growth factors and scaffolding materials, this technique has the potential to generate custom made bone grafts. The main objectives for this thesis were to optimize the conditions for bone tissue engineering, to introduce new perspectives and …
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Rapid 3-D laser microprinting of bioscaffolds and patterning of proteins
… microarchitectures and chemical cues to support cell migration, proliferation and differentiation. The majority of tissue engineering strategies use porous scaffolds containing chemical cues for culturing cells. However, these methods are unable to truly recapitulate the complexity of the in-vivo …
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The Impact of Lipid Nanoparticle Chemistry on RNA Delivery and Therapeutic Outcomes
… ionizable cationic lipid component, impact RNA delivery. To systematically investigate how PEG lipid chemistry impacted LNP formulation and RNA delivery, a series of linear-dendritic poly(ethylene glycol) (PEG) lipids were synthesized with modulated hydrophobic domains. The chemical structure of …
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Engineered Tracking and Delivery of Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells (MSCs) are tissue culture plastic adherent cells that are able to differentiate into multiple cell types, modulate the immune system, and aid in wound repair. These versatile cells are thus being investigated to treat a wide variety of different diseases such as graft vs. …
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Development and mechanistic analysis of in vivo liposomal nanoparticle delivery of siRNA and mRNA
… difficulties of efficaciously delivering RNA to cells in vivo. Liposomal nanoparticles (LNPs) have shown some success, but their design is limited by both a lack of information concerning the optimal lipid composition and insufficient data regarding the LNPs' interaction with their environment. …
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Developing an Inducible Osteoclast System as a Cell Therapy for Ectopic Calcification
… mineral in vivo and we hypothesized that a cell therapy based on inducible osteoclast differentiation could be used as a cell therapy to treat EC and HO. The RANK/RANKL pathway is a critical step in osteoclast differentiation and we created an inducible RANK (iRANK) fusion protein which …
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Ricin B Chain-Insulin Fusion Protein Immunomodulation of Type 1 Diabetes
… of the insulin-producing pancreatic islet β-cells that results from a combination of genetic and environmental factors. Attempts to suppress Th1-mediated autoimmune diseases such as T1D by mucosal delivery of autoantigens for immunotolerization have yielded only partial success. Attainment of …
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Collagen scaffolds and injectable biopolymer gels for cardiac tissue engineering
… scaffolds have begun to shown promise for cell delivery for cardiac tissue engineering. Although various polymers and material forms have been explored, there is a need for: injectable gels that meet certain design specifications; a more indepth characterization of the scaffold properties; …
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