Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"cell deformation"”.
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Hybrid Ray Optics and Continuum Mechanics Modeling of Cell Deformation in the Optical Stretcher
… observed trapping and stretching of biological cells and other dielectrics. Hence, mathematical and computational models have been developed to calculate the optical stress and net stretching force. The ray optics (RO) model assumes that the light field can be divided up into very narrow …
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Viscoelastic two-dimensional modeling of cell deformation due to shear stress on apical focal adhesion, with experimental design considerations
Introduction: Cells are exposed to a wide variety of forces within the human body, and the mechanisms by which cells respond to these forces are largely unknown. From altering gene transcription in the cell nucleus to conformational changes in membrane channel proteins that lead to increased or …
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Effects of cytoskeletal protein disruption on the deformation of MSCs during chondrogenesis
… Adult bone marrow derived mesenchymal stem cells are undifferentiated, multipotent cells that have the ability to differentiate into the chondrocyte-like cells found within the nucleus pulposus of the adult intervertebral disc. This study examines one determinant of the cellular …
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Hierarchical cell fluid extracellular matrix interaction in cell microenvironment
… structural interactions between components of cell microenvironment, the extracellular matrix (ECM), cytoplasm, nucleus and fluid, are important phenomena that decide cell level physiological process and tissue engineering applications. One of those tissue engineering modalities is freezing of …
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Behavior of deformed dermal fibroblasts seeded on a silicon membrane under high levels of strain
… of human dermal fibroblasts as a response to deformation produced by a normal force that can lead to the potential formation of stretch marks in pregnant women, adolescents, and people with Cushing's syndrome. The main function of dermal fibroblasts is to produce the essential fibrous …
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Influence of Extracellular Matrix Stiffness and Topography on Neuronal Cell Behavior and Neurite Outgrowth
… is on the promotion and growth of neuronal cells. In vitro research attempts to improve this by modifying the stiffness and topography of the extracellular matrix (ECM). However, the limitations of in vitro experiments make it difficult to control the individual factors influencing neuronal …
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Uniaxial Mechanical Assays on Adherent Living Single Cells : Animal Embryonic Fibroblasts and Human Pancreas Cancer Cells
… complexity, animals, living tissues and cells, the smallest unit of live, are subjected to physical principles. In living tissues, permanent or transient regulation processes, such as biochemical and mechanical interactions between a single cell and its environment are essential to …
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Mechanical characterization of lithium-ion battery micro components for development of homogenized and multilayer material models
… mechanical properties so that individual battery cells and battery packs can be characterized during crash events. The objective of this research is to better understand the battery component (electrode and separator) properties under different loading conditions. In this work, over 200 tests were …
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Investigation of Single-Cell and Blood-Brain Barrier Mechanics after Electroporation and in Primary Brain Cancers
Cell-level and tissue-level mechanical properties are key to healthy biological functions, and many diseases and disorder arise or progress due to altered cell and tissue mechanics. Pulse electric field (PEFs), which employ intense external electric fields to cause electroporation, a phenomenon …
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Electrohydrodynamic Simulations of Capsule Deformation Using a Dual Time-Stepping Lattice Boltzmann Scheme
… their use in modeling the response of red blood cells to external forces. These models can be used to study the cell’s material properties and can also assist in the development of diagnostic equipment. In this work we develop a three dimensional model for numerical simulations of red blood cells …
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Regulation of cartilage metabolism by dynamic tissue shear strain and the mechanical characterization of cartilage
… a new instrument was developed to apply axial deformations as small as lµm and sinusoidal rotations as small as 0.5% up to 4% based on 1 mm thickness of tissue under feedback control. This apparatus is small enough (30 cm high x 25 cm x 20 cm) to be placed in a standard incubator for long-term …
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Mechanical characterisation of mammalian cells during monolayer formation using atomic force microscopy
Exploring the elasticity of mammalian cells - through interpretation of the Young’s elastic modulus [E] - has become one of the most useful benchmark biomarkers for investigating the relationship between the physiological and mechanical properties of cells. Such investigations have, until now, …
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Deformation-assisted antifouling of surfaces
… new surface materials, surface vibration, large deformation or heating (for deicing only) The problem of fouling is especially severe in the case of membrane processes due to the variety of foulant types that comes in contact with the membrane surface, the limitation, and complexity of …
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Mutations in a Mechanosensitive Channel Enable Intravascular Metaststic Cell Survival
… that are enriched in metastatic breast cancer cells and predicted to significantly alter protein function. The pro-metastatic role of one of these mutations—a nonsense alteration that yields a truncated pannexin-1 (PANX1 1-89) plasma membrane megachannel subunit—was functionally characterized. …
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Mechanical algal disruption for efficient biodiesel extraction
… route to improving this is via disruption of the cells prior to lipid extraction, which can significantly increase energy recovery. Unfortunately, several obvious disruption techniques require more energy than can be gained. This dissertation examines the use of microbubbles to improve mechanical …