Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"cell deformability"”.
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Tumor cell deformability in the metastatic cascade
During the process of metastasis, tumor cells must undergo changes that enable them to detach from a tumor, exit surrounding tissue during intravasation, enter into circulation and eventually stop at a distant site for extravasation. Here, we measure the physical changes in the deformability of …
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The relevance of red blood cell deformability in the pathophysiology of blood disorders
Red blood cells (RBCs) play a crucial role in delivering oxygen to the body tissues. During the 120 days of their lifespan, average RBCs would circulate for approximately 500,000 times and undergo repeated deformations in small blood capillaries and splenic cords. Increased RBC clearance in the …
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A microvillus based approach to model cell rolling
Cell rolling is a physiological phenomenon, which allows leukocytes to attach to activated vascular endothelium and reach sites of inflammation. A novel approach to model cell rolling is presented in this thesis. The model incorporates all the aspects known to be important to rolling in a …
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Nanoparticle-Based Drug Delivery and the Impacts on Cancer Cell Biophysical Markers
… progression and physiological changes within the cells are accompanied by alterations in the biophysical properties. Therefore, the cell biophysical properties can serve as promising markers for cancer detection and physiological activities. To aid in the investigation of the biophysical markers …
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Label-Free Microfluidic Devices for Single-Cell Analysis and Liquid Biopsies
… sample sizes. Label-free technologies rely on cell biophysical characteristics to identify, evaluate, and study biological samples. Biomechanical probing of cells through deformability assays provides a label-free method of identifying cell health and monitoring response to physical and …
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The AFM Study of Ovarian Cell Structural Mechanics in the Progression of Cancer
… deciphering the complex structure of individual cells and understanding the symptoms of cancer disease has been a highly emphasized research area. The exact cause of Cancer and the genetic heterogeneity that determines the severity of the disease and its response to treatment has been a great …
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Erythrocyte deformability as assessed by nuclepore filters
Erythrocyte deformability characteristics were assessed by passing red cell suspensions through Nuclepore polycarbonate filters having pore diameters of 3 ym. with pore lengths of 12 ym. During flow through these filters, at a constant flow rate of 2.17 cc/min., the pressure drop across the filter …
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Multi-Constriction Microfluidic Sensors for Single-Cell Biophysical Characterization
… easy-to-use technologies capable of classifying cells. Analysis of cell behavior in microfluidic deformability assays provides a label-free method of observing cell response to physical and chemical stimuli. This body of work shows advancements made toward reaching our goal of a robust and …
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Accelerated Lattice Boltzmann Method For Colloidal Suspensions Rheology And Interface Morphology
… approached by assuming the red blood cells as surfactant covered droplets. The effects of interfacial tension on the flow velocity and the droplet exclusion from the walls in parabolic flows were in qualitative agreement with some experimental and numerical results. The Fahraeus and …