Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"cell decision"”.
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Quantitative analysis of the cytokine-mediated apoptosis-survival cell decision process
How do cells sense their environment and decide whether to live or to die? This question has drawn considerable interest since 1972, when it was first discovered that cells have an intrinsic ability to self-destruct through a process called apoptosis. Since then, apoptosis has been shown to play a …
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Understanding cell decision-making using near-infrared quantum dots: One cell, one molecule at a time
Cell receives input signals such growth factors from the environment and decides an appropriate output such as migration, division, differentiation, and apoptosis. This decision making process is tightly controlled, and when misregulated leads to pathogenesis such as cancer, immune disease, and …
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Quantitative analysis of cell decision processes in response to inflammatory cues and their role in mediating genotoxicity in hepatocytes
… that inflammation may provide cues that allow cells to survive in the face of significant DNA damage as well as cues that foster cell proliferation. This study sought to elucidate changes that influence hepatocyte decision processes under conditions of chronic inflammation by using a set of …
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A novel high-throughput in-cell Western assay for the quantitative measurement of signaling dynamics in DNA damage signaling networks : cell decision processes in response to DNA double strand breaks
Following exposure to DNA damage, cells initiate a stress response involving multiple protein kinase signaling cascades. The DNA damage response results in one of several possible cell-fate decisions, or cellular responses: induction of cell-cycle arrest, initiation of DNA repair, activation of …
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Relating topology and dynamics in cell signaling networks
Cells are constantly bombarded with stimuli that they must sense, process, and interpret to make decisions. This capability is provided by interconnected signaling pathways. Many of the components and interactions within pathways have been identified, and it is becoming clear that the precise …
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Single cell decisions in endothelial population in the context of inflammatory angiogenesis
… the agent based model, in which individual cells are modeled as autonomous decision making entities, has become an important tool for simulating complex phenomena including angiogenesis. The reliability of these models depends on model validation by quantitative experimental characterization …
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Cellular decision making at the nanoscale
The well-established dependence of cell traction forces on the compliance of supporting matrices has been attributed to levels of force exerted on components in focal contacts. Here, use of novel, force-limited nanoscale tension gauges revealed that both force and substrate deformations govern cell …
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Regulation and switching in bacterial gene expression networks in response to nutrients
… It is of general interest to understand cell decision making in response to environmental cues. One well-known strategy is phenotypical heterogeneity where different individuals inside a population utilize different niches and resources within the same environment. Such strategy has the …
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The Initial Events of T-Cell Activation in Realistic Model Systems
T cells are part of the cellular component of the adaptive immune system and specifically recognise foreign antigens in the body. They use their membrane-bound T-cell receptor (TCR) to bind small peptide antigens presented within the major histocompatibility complex (pMHC) on the surface of antigen …
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Cellular decision making: from phage lambda to stem cells
Cellular decision making is the process by which cells choose among functionally-distinct cell states. Heritable cell states are typically maintained and stabilized by the activity of specific genes, but cells can also be induced to switch to alternative states given the appropriate stimulus. …
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Hilaruuduille simuloitujen toimenpide-ehdotusten johtaminen kuviolle päättelysääntöjen avulla
Suomen metsäkeskus tuottaa toimenpide-esityksiä sisältävää metsävaratietoa metsänomistajien ja toimijoiden käyt-töön. Metsävaratieto tuotetaan pääasiassa kaukokartoituksella valtakunnalliseen Aarni- järjestelmään. Kuviokohtai-set hoito- ja hakkuuehdotukset tuotetaan yleensä simuloimalla. Jokaisella …