Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"cell death pathway"”.
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Gingival MSCs Improve Bone Phenotype in Ovariectomy-Induced Osteoporosis via Programmed Cell Death Pathway
… health institutions. Gingival Mesenchymal Stem cells (GMSCs) are a distinctive population of dental tissue-derived stem cells that possess uniquely high proliferation abilities and are capable of self-maintenance and multipotent differentiation. Their use has been investigated in different …
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THE PROSURVIVAL ACTIVITIES OF APOPTOSIS-INDUCING FACTOR CONVERGE UPON THE REGULATION OF MITOCHONDRIAL METABOLISM, A NOVEL CELL DEATH PATHWAY, AND THE PROGRESSION OF PROSTATE CANCER
… for its apoptotic function, AIF-mediated cell death has emerged as an atypical cell death pathway; and accumulating evidence indicates AIF to play a more significant role in cell survival by maintaining mitochondrial homeostasis. A loss in AIF protein leads to a variety of …
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Characterization of three Drosophila melanogaster regulators of programmed cell death that lead to caspase activation
Programmed cell death plays an important part in metazoan development as well as in disease. The morphology of cells undergoing programmed cell death has been carefully defined and found to be conserved between a variety of species. A number of key regulators of this process were first identified …
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Identification and characterisation of a novel gene, DWNN, isolated from promoter-trapped Chinese hamster ovary cells
… destruction of foreign antigens by cytotoxic T cells and is of crucial importance to the defence of the organism against viral infections. Defects in this process can lead to various autoimmune diseases and cancer. The aim of this study was to identify more genes involved in the cell death …
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Role of RIP3 in DNA damaging agent-induced breast cancer cell death
… player in “programmed” or “regulated” necrotic cell death pathway. Here we show that programmed necrosis is activated in response to chemotherapeutic agents and contributes to chemotherapy-induced breast cancer cell death. However, we also show that RIP3 expression is silenced in basal like …
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The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondii
… immune responses. IFN-γ is mainly secreted by T cells and natural killer (NK) cells and activates macrophages, promotes antigen presentation and enhances antiviral and antibacterial immunity. In the case of bacterial pathogens, such as S.Typhimurium, priming with IFN-γ leads to an inflammatory …
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Overexpression of Amyloid Precursor Protein Induces Mitochondrial Oxidative Stress and Activates the Intrinsic Apoptosis Pathway
… unclear. Here, we elucidated the mechanism of cell death induced by overexpression of wild type APP. Chinese hamster ovary cells transfected with a DsRed-APP fusion construct displayed caspase-3 activation and nuclear fragmentation indicative of apoptosis. APP-induced apoptosis was blocked by a …
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Synergic Effect on Cell Death by Co-treatment with TRAIL and Human Anti-DR5 Antibody
DR5 and DR4, death receptors of TNF-related apoptosis-inducing ligand (TRAIL), are interesting targets of antibody-based cancer therapy since TRAIL itself selectively induces apoptotic cell death in cancer cells but not in normal cells. In previous study we isolated a human single-chain variable …
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Thioredoxin-1 Inhibition Promotes MLKL Activation: Biochemical Insights Into a Suppressor of the Necroptotic Pathway
Necroptosis is an immunogenic caspase-independent cell death program. While mainly serving to defend against viral infection, dysregulated necroptotic signaling contributes to the pathology of a growing number of human diseases associated with inflammation, neurodegeneration, and ischemic injuries. …
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A Novel Cardiac Function of Sumo2/3 and Senp5 Dependent Pathway and Its Physiological Impact On Congestive Cardiomyopathy
… cardiac function of SUMO2/3 and SENP5 dependent pathway and its physiologic impact on congestive cardiomyopathy</strong></p> <p>Publication No.___________</p> <p>Eun Young Kim, M.S.</p> <p>Supervisory professor: Robert J. Schwartz, Ph.D.</p> <p>SUMOylation regulates diverse cellular processes …
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The Role of CK1 in Necroptosis and Confirmation of Amyloid-Like Fibers in Necroptosis Using 2D SDD-AGE
Necroptosis is a regulated necrotic cell death pathway, mediated by a supermolecular complex called the necrosome, which contains receptor-interacting protein kinase 1 and 3 (RIPK1, RIPK3) and mixed-lineage kinase domain-like protein (MLKL). Phosphorylation of human RIPK3 at serine 227 (S227) has …
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Discovery of the First Endogenous Gain of Function Mutation in Drosophila RAS1 as a Dominant Suppressor of Apoptosis
<p>The development of multicellular organisms requires a tight coordination of cell proliferation, cell differentiation and cell death in order to correctly specify cell fate and number. According to the trophic theory of survival, this is achieved in part by a competition between cells in a tissue …
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Complex N-Glycosylation in Anti-Tumor Immunity
… the third leading cause of cancer-related death in the United States. The five-year survival rate of thirteen percent can be attributed to a difficulty in early detection and a lack of effective treatments. Tumor-associated glycans represent a potential anti-tumor target for two reasons: …
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Biochemical and Molecular Characterisation of the FADDosome
… However, acquisition of resistance by cancer cells is the main cause of the limited clinical use of 5-FU, which needs to be overcome to widen and lengthen its utility. Therefore, it is necessary to investigate the factors and pathways involved in 5-FU-induced apoptosis. Chemotherapeutic …
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Screen for Suppressors and Enhancers of Excitotoxic Neurodegeneration
… is facilitated by strong research tools, and cellular mechanisms are highly conserved through evolution. We produced a reliable model for excitotoxicity in the nematode <em>C. elegans </em>(the <em>Δglt-3;nuIs5 </em>strain) and we now use this model to screen for genes whose mutation can alter …
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Starvation Response in Caenorhabditis elegans
… of environmental nutrients is limited, multicellular animas can make physiological and behavioral changes so as to cope with nutrient starvation. Although starvation response is essential for the survival of animals during nutrient deprivation, uncontrolled or uncoordinated starvation …
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Uncovering the Role of 5'-Nucleotidases in Pyrimidine Metabolism in Trypanosoma brucei
… nucleic acids and nucleotide sugars through two pathways: pyrimidine salvage or de novo synthesis using glutamine. However, T. brucei lacks several key pyrimidine transporters and enzymes found in mammals, creating an area of parasite vulnerability, especially in the ability to maintain balance …
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Regulation of Histone Covalent Modifications During Yeast Apoptosis
… 10 (H2BS10ph) in a hydrogen peroxide-induced cell death pathway. Unlike Mst1, Ste20 translocates into the nucleus in a caspase-independent fashion to mediate phosphorylation of H2B. H2BS10ph is dependent on the removal of acetylation mark on adjacent lysine residue, (H2BK11ac), which exists in …
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Components of the Ubiquitin Proteasome System are Required for the Nonapoptotic Death of the C. Elegans Linker Cell
<p>Cell death is a major cell fate that promotes tissue sculpting and morphogenesis during animal development. Many developmental cell-culling events cannot be accounted for solely by caspase-dependent apoptosis, yet, alternate pathways are poorly understood. Direct evidence that …
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The Regulation of Cellular Iron Metabolism
… for life, but it presents a challenge to our cells because of its ability to drive free radical formation that damages proteins, lipids and DNA. While the consequences of iron excess or deficiency for disease are well described, it has only been recently recognised that iron-induced cell …
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