Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"cell cytokines"”.
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T cell mediated satellite cell function: implications for age-associated changes in skeletal muscle regeneration
… that an age-associated loss of muscle precursor cell (MPC) functionality contributes to sarcopenia. Current research also suggests that T cells of the immune system may influence skeletal muscle repair via signaling with MPCs. The objective of the present study was to examine the influence of …
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Impact of cationic host defence peptide LL-37 on human neutrophil death and inflammatory responses
… of apoptotic PMN, in contrast to necrotic cells, is proposed to promote the resolution of inflammation. In this thesis I demonstrate that the human cathelicidin LL-37 rapidly induced secondary necrosis of apoptotic human PMN and identify the essential C-terminal region of LL-37 required for …
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Tumour infiltrating T cells in non-small cell lung cancer and their interactions with cancer-associated fibroblasts
… is aimed at reinvigorating local cytotoxic T cells, however the rate of immunotherapy failure in non-small cell lung cancer (NSCLC) is as high as 80%. An improved mechanistic understanding of immunosuppressive pathways in NSCLC is important to develop novel diagnostic and therapeutic …
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TREM-2 and Dendritic Cells in the Pathogenesis of Allergic Airway Inflammation
… characterized by reversible airway obstruction, cellular infiltration, airway inflammation and airway remodeling. Dendritic cells (DCs) are professional antigen presenting cells that initiate the asthmatic inflammatory response by capturing inhaled antigens and migrating to the lymph nodes to …
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Wirkung der proinflammatorischen Zytokine TNFα und IL-1β auf die Aktivität und die Proteinmenge der Dual-Leucine-Zipper-Bearing Kinase in einer Betazelllinie
Beim Diabetes mellitus Typ 2 kommt es durch eine Dysbalance von Replikation und Apoptose der pankreatischen Betazellen sowie durch eine periphere Insulinresistenz zu einer gestörten Glukosehomöostase. Die proinflammatorischen Zytokine TNFα und IL-1β sind dabei wichtige pathogene Effektoren, wobei …
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Psoriasis activation of cells important in cardiovascular disease
… risk is widely speculated. Endothelial cells and macrophages are central players in the immunopathological development of both diseases. Interleukin-36 cytokines (IL-36) have been heavily implicated in psoriasis immunopathology. Significant upregulation of epidermal IL-36 is a recognised …