Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 51 for “"cell cycle regulators"”.
-
HIF2a regulates ccRCC tumorigenesis through activation of cell cycle regulators
Clear cell renal cell carcinoma (ccRCC) is the most frequent type of kidney cancer, with 50% 5-year survival. Genetically, ccRCCs are characterised by inactivation of VHL which is lost in 90% of cases. Inactivating mutations of VHL lead to stabilisation of HIF2α which in turn drives the expression …
-
Investigating the role of cell cycle regulators in mesoderm specification
… this dissertation I use human pluripotent stem cells (hPSCs) as a simplified model of human development. Studies have shown that the cell cycle machinery plays a direct role in the differentiation of endoderm and ectoderm lineages but its role in guiding mesoderm subtype formation remains …
-
The molecular and biochemical characterization of cell cycle regulators in Pisum sativum
… focuses on the characterization of cdc2-type cell cycle regulators in Pisum sativum (garden pea). Immunoblot patterns indicate that $\sim$34 kDa cdc2-type proteins present in protein complexes may be phosphorylated in pea. As in other systems, these proteins copurify with a histone H1 kinase …
-
Isolation and characterization of the SIAMESE family: a novel class of cell cycle regulators in plants
… SIAMESE (SIM) gene of Arabidopsis result in multicellular trichomes harboring individual nuclei with a low ploidy level, a phenotype strikingly different from that of wild-type trichomes, which are single cells with a nuclear DNA content of approximately 16-32C. These observations suggested that …
-
The histopathology and immunohistochemical expression of cell cycle regulators and mismatch repair gene proteins in colorectal carcinoma : a comparative study
… is possible that tumour morphology, location and cell cycle markers may be indicators of the underlying molecular mechanism. In a resource limited setting these factors may help to stratify which cases need further molecular testing and genetic counselling. Aims and objectives: To characterise the …
-
Human immunodeficiency virus (HIV) and Human papillomavirus (HPV) infection and cell cycle regulators in preinvasive lesions and invasive carcinomas of the anus
… The majority of these carcinomas are squamous cell carcinomas and are associated with high risk-HPV infection. HIV infection appears to interact synergistically with high risk-HPV in the development of squamous cell carcinoma at this site. Aims and objectives: To review the pathology of anal …
-
Evaluating the role of the fission yeast cyclin B Cdc13 in cell size homeostasis
Most cellular proteins retain a stable concentration as cells grow and divide, but there are exceptions. Some cell cycle regulators change in concentration with cell size. In fission yeast, Cdc13 (cyclin B), an important activator of the core cell cycle kinase Cdc2 (CDK1), increases in …
-
Enhanced protein degradation by branched ubiquitin chains
Posttranslational modification of cell cycle regulators with ubiquitin chains is essential for eukaryotic cell division. Such chains can be connected through seven lysine residues or the amino-terminus of ubiquitin, thereby allowing the assembly of eight homogenous and multiple mixed or branched …
-
Cell cycle regulation during gametogenesis in budding yeast
… reproduction depends on meiosis, the specialized cell division that gives rise to gametes. During meiosis, two consecutive rounds of chromosome segregation follow one round of DNA replication to yield four haploid gametes from one diploid progenitor. In meiosis I, homologous chromosomes segregate …
-
Dissecting the function and targets of FOXG1 in glioblastoma
… These tumours comprise a mixture of neural stem cell-like cells and more differentiated astrocytic cells. The former are thought to be responsible for tumour development and recurrence, and display self-renewal and differentiation capacity in vitro. Glioma stem cells (GSCs) are defined …
-
The role of conexin 43 in murine sertoli cell development
Sertoli cells are the only somatic cell type present within the seminiferous tubules of the testis. The support of these somatic cells is essential for testis formation and spermatogenesis. They are called mother or nurse cells, implicating their intimate association with germ cells and also their …
-
Oesophageal squamous cell carcinogenesis : a study of cell cycle regulatory proteins by immunohistochemistry
Oesophageal squamous cell carcinoma (OSCC) is a highly malignant tumour that has a poor prognosis and shows marked regional variation in its incidence, implicating environmental factors. South Africa is one of several countries that has areas of high incidence. The exact aetiopathogenesis of OSCC …
-
P107 negatively regulates the neural precursor pool by repressing Hes1 transcription
Stem cells are defined by their multipotentiality and their long-term ability to self-renew. P107, a member of the pocket protein family of cell cycle regulators has previously been shown in our laboratory to negatively regulate neural precursor cell number and self-renewal (Vanderluit et al., …
-
Studying the Effect of Low Doses of Ionization Radiation on Senescence in Human Lung Fibroblasts.
… low doses of ionizing radiation (LDR: <100mGy), cells and organisms are benefitted with delayed ageing, improved immunity and reduced cancer growth. These intriguing findings have proposed the “Radiation Hormesis” hypothesis. Herein, I studied the senescence effects of LDR exposure to normal …
-
The roles of human cytomegalovirus US27 gene product during virus infection
… involves extensive manipulation of host cellular functions and immune responses. HCMV encodes four genes for putative G protein-coupled receptors (GPCRs): US27, US28, UL33, and UL78. The US28 gene product is a functional chemokine receptor that exhibits a variety of signaling outcomes. In …
-
The Effect of Stress Induced Premature Senescence on the Expression of Heterogeneous RibonucleoIeoprotein
… nuclear ribonucleoproteins (hnRNP) in cellular senescence is yet to be defined. Cellular senescence is a terminal growth arrest in somatic cells. It is thought to be the consequence of telomeric shortening that acts as a DNA damage signal. Conversely, cells induced into premature …
-
Molecular Mechanisms of Mitotic Checkpoint Complex Assembly onto Kinetochores
… preventing APC/C-mediated degradation of two key cell cycle regulators, cyclin B and securin. The MCC is composed of BubR1, Cdc20 and Mad2, and while their assembly is an intrinsically very slow process, in cells it is catalytically activated. Recent work points towards hierarchical recruitments …
-
Understanding Acquired Resistance to Lapatinib In Breast Cancer Cells
… malignant transformation of mammary epithelial cells. ErbB family members are often over-expressed in human breast carcinomas. Lapatinib is an ErbB1 and ErbB2 tyrosine kinase inhibitor that has been shown to have anti-proliferative effects in breast and lung cancer cells. Cells treated with …
-
The Role of The Androgen Receptor Cofactor P44/Wdr77 In Astrocyte Activation
… and differentiation of prostate epithelial cells. In the present study, we found that deletion of the p44 gene in the mouse brain caused accelerated aging with dramatic astrogliosis. The p44/WDR77 is expressed in astrocytes and loss of p44/WDR77 expression in astrocytes leads to …
-
Overcoming Resistance to CDK4/6-targeted Therapy Using JAK2/STAT3 Inhibitor in Triple-Negative Breast Cancer
… kinase 4 and 6 (CDK4/6) are major cell cycle regulators that control G1 to S phase transition and aberrant hyperactivation of the CDK4/6 pathway results in uncontrolled cell proliferation. Although three CDK4/6 inhibitors (CDK4/6is) have achieved clinical benefits in …
Page 1 of 3