Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"cell cycle regulator"”.
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Inhibition of Hox function by the cell cycle regulator geminin
… vom. Zellzyklus, mit dem Chromatin Hox-regulatorscher DNA-Elemente und mit Hox-Proteinen assoziiert. Funktionsgewinn und verlust Experimente im Hühnerneuralrohr haben gezeigt, dass Geminin die anteriore Grenze der Hoxb9-Transkription moduliert, was auf eine Polycomb-ähnliche Aktivität …
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The regulation of genes involved in trichome development
… of Arabidopsis thaliana are macroscopic single cells that have been used as a model system for cell fate determination, cell expansion, cell cycle regulation, cell wall deposition, as well as other processes. Initiation of the trichome cell fate is controlled by a complex of genes including …
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Aberrante DNA-Methylierung des Transkriptionsfaktors C/EBP[alpha] bei akuter myeloischer Leukämie
… (MDS). We showed, that in hematopoietic tumor cell lines, CpG island hypermethylation of the proximal C/EBP alpha promotor region was associated with transcriptional silencing, and treatment with the demethylating agent DAC resulted in C/EBP alpha reexpression and promotor demethylation. C/EBP …
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Gene Repression and Cell Cycle Regulation by PU.1 in Acute Myeloid Leukemia
… for the development of nearly all white blood cell types of the immune system, including B cells, granulocytes, and monocytes. Mutation of the gene encoding PU.1, SPI1 in humans and Sfpi1 in mice, is associated with AML. We hypothesized that reduced expression of PU.1 in Sfpi1BN/BNmyeloid cells …
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Functional role of GSK3β in p38MAPK mediated human amnion membrane senescence
… Our study determined changes in multipotent pro-cell cycle regulator glycogen synthase kinase (GSK) 3β and its regulation by p38MAPK in effecting senescence to further delineate the molecular mechanism involved in senescence. We report that OS resulted in phosphorylation of GSK3β (inactivation) …
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The cellular and molecular mechanisms of glucocorticoid-induced growth retardation
… The work of this thesis has investigated the cellular and molecular mechanisms involved in mediating GC effects at the growth plate. Affymetrix microarray has been used to identify and characterise the expression of lipocalin 2, a novel GC-responsive chondrocyte gene which may contribute to …
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The effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on oxidative and hypoxic stress in the vascular endothelium
… inhibitors (statins) improve endothelial cell (EC) function by enhancing the synthesis of Nitric Oxide (NO) and attenuating the endothelial leucocyte interaction and platelet aggregation. However the effects of statins on endothelial cell proliferation, apoptosis and the mediators of these …
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Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium
… (CK) 19-positive phenotype in mammary cancer cells in vivo and in vitro and suggest that hypoxiainduced dedifferentiation is one of the mechanisms behind hypoxia-driven malignant progression. Hypoxia was also found to significantly impair both morphological and functional differentiation of …
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Links Between Adhesion Signalling and Cell Cycle Regulation in Bladder Cancer Cells
… to identify new avenues for therapy. The extracellular matrix (ECM) represents a key component of the tumour microenvironment whose biochemical and mechanical characteristics contribute to all the hallmarks of cancer. However, the role of the ECM in bladder cancer is yet to be fully explored. …
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Development of in vivo tumour models for non-invasive proof-of-principle investigation of novel therapeutic agents. Engineering and characterisation of bioluminescent cell reporter systems for in vivo analysis of anti-cancer therapy pharmacodynamics.
… drug-target interactions. Engineering of cancer cells to express fluorescent or bioluminescent proteins, either endogenously or under the control of specific gene promoters, and their detection by noninvasive optical imaging has the potential to improve preclinical drug development. In this …
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Inhibition of the transcription factor AP-1 in cervical cancer
… that regulates numerous genes involved in cell proliferation, differentiation and oncogenesis. The expression of AP-I is shown to play an important role in many human cancers and plays a key role in the regulation of the E6 and E7 oncoproteins of high-risk Human Papillomaviruses (HPV) that …
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Analysis of the function of the Nf2 tumor suppressor protein, Merlin
… actin cytoskeleton. However, the molecular and cellular functions of this tumor suppressor gene were largely unknown when the work described here began. Mutational analysis of Nf2 in flies has lead to the identification of a dominant-negative allele, which harbors mutations in the amino-terminal …
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A CELL CYCLE CLOCK REGULATES THE EPIGENETIC LANDSCAPE OF AML CELLS AND DETERMINES SENSITIVITY TO LSD1 INHIBITION
… target. We revealed a crucial role for the cell cycle regulator p21 in determining sensitivity to LSD1 inhibition. Our findings further demonstrate that pharmacological prolongation of the cell cycle, specifically the G1 phase, can sensitize AML cells to LSD1 inhibitors. This is achieved …
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Mechanisms of p19Arf-Mediated Regulation of Perivascular Cell Biology During Mammalian Eye Development
… critical interrogation for its role as a potent cell cycle regulator and tumor suppressor. In the last decade, there has been considerable evidence describing an essential function for p19Arf during mammalian eye development. In this context, p19Arf is required for the ultimate involution of the …
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Artemis Interacts With The Cul4A Ubiquitin E3 Ligase Complex and Regulates The Cell Cycle Progression
… ATM and ATR in response to a variety of cellular stresses. Artemis has important roles in V(D)J recombination, DNA double strand breaks repair and damage-induced cell-cycle checkpoint regulation. The detailed mechanism by which Artemis mediates its functions in these cellular pathways …
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Induction of Cellular Induction Senescence by BTG2_(TIS21/PC3) Gene in Huh7 Hepatocellular carcinoma Cells
… regulates G1-S and G2-M progressions of cell division cycle through the inhibition of G1 phase cyclin biosynthesis, and the delayed degradations of cycin B1 and cyclin A, respectively. Therefore, we earlier suggested that TIS21 might play a role as a pan-cell cycle regulator and an …
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Cancer cell behaviour following parasite exposure
… cancer development and progression, or which cellular mechanisms are altered following exposure. Using several in vitro and in vivo techniques, this study aimed to determine the effect that certain helminths have on the progression of cervical and colorectal cancer. The results revealed that …
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Phosphorylation-based control of cellular asymmetry and the cell cycle in Caulobacter crescentus
Asymmetric cell division allows for better environmental adaptation and organismal complexity. Cells often divide by binary fission to form two identical daughter cells with similar developmental fates. However, a cell can also divide asymmetrically to form two daughter cells with different …
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New mechanisms in transcription regulation and chromosome organization in Caulobacter crescentus
… DNA is tightly compacted and organized inside cells. In bacteria, nucleoid-associated proteins (NAPs) play critical roles in shaping and compacting the chromosome by bending, wrapping and bridging the DNA. The binding of these proteins can also profoundly affect gene expression regulation. In …
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