Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"cell cycle inhibitor"”.
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Notch signaling and cell cycle inhibitor regulation in pituitary organogenesis
The pituitary is plastic organ whose hormone cell number can fluctuate depending on physiologic need. Alterations in pituitary cell expansion can lead to disorders such as pituitary hyperplasia or tumors, which have a high prevalence in the human population. Precise control of cell cycle …
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I. Isolation and Characterization of Bioactive Compounds From Suriname and Madagascar flora. II. A Synthetic Approach to Lucilactaene
… studies, a synthetic approach to lucilactaene, a cell cycle inhibitor was developed.
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DNA stress checkpoint control in Arabidopsis thaliana by WEE1
The WEE1 kinase is a conserved cell cycle inhibitor that, together with CDC25, controls CDK activity and consequently the G2/M progression in yeast and animals. The same control mechanism is utilized by the DNA damage checkpoint to induce a cell cycle arrest upon DNA stress. In plants, a homolog of …
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Functional and structural uncoupling of the angiogenic and enzymatic inhibitory activity of TIMPs : loop 6 of TIMP-2 is a novel inhibitor of angiogenesis
Tissue inhibitors of metalloproteinases (TIMPs) regulate tumor growth, progression and angiogenesis in a variety of experimental cancer models and in human malignancies. However, numerous studies have revealed important differences between TIMP family members in their ability to inhibit angiogenic …
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Roles of Zinc in Skeletal Muscle Cells Growth
… examined. Zinc at concentrations that altered cell proliferation did not alter IGFBP-3 inhibition of IGF activity. The effects of extracellular zinc on IGF-1R signal transduction were examined using the non-membrane permeable chelator DTPA. Zinc was important for IGF activity via both IGF-1R …
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Dissecting the function and targets of FOXG1 in glioblastoma
… These tumours comprise a mixture of neural stem cell-like cells and more differentiated astrocytic cells. The former are thought to be responsible for tumour development and recurrence, and display self-renewal and differentiation capacity in vitro. Glioma stem cells (GSCs) are defined …
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Altering the ADIPO: LEP Ratio Secreted by Obese Adipose Tissue affects the Tumor Growth Microenvironment of MCF7 Breast Cancer Cells
… its membrane receptor AdipoR1 and activate the cell signalling pathway AMPK, stabilizing the cell cycle inhibitor protein p27, leading to cell cycle arrest. Leptin on the other hand binds to its membrane receptor Ob-Rb and activates the Akt signaling pathway, increasing the cytoplasmic …
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Targeted Epigenetic Editing to Increase Adult Pancreatic Β-Cell Proliferation
β-cell replacement therapy is potentially a curative approach in treating diabetes, as demonstrated by the success of pancreatic islet transplantation in type 1 diabetes. However, there are an insufficient number of organ donors to meet the demand of this disease, which is increasing in prevalence. …
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Mechanisms of pain processing: spinal protein translation in the rat
… and such mechanisms are widely believed to be cellular counterparts of long-term memory. Relevant to mammalian pain nociceptors is the realisation that messenger ribonucleic acid (mRNA) in dendrites, axons, axon terminals as well as cell bodies, is essential for long-term synaptic plasticity …
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Molecular changes involved in oral cancer progression and their relevance to keratinocyte immortalisation
… of normal oral mucosa, dysplasias and squamous cell carcinomas we have identified molecular changes characteristic of early oral cancer progression. Our group reported previously that acquisition of the immortal phenotype is an early event in oral cancer development (McGregor et al. 1997): data …
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The Role of SOX2 in Colon Cancer Progression
… region Y)-box 2 (SOX2) is one the embryonic stem cell transcription factors that is capable of reprogramming adult differentiated cells into an induced pluripotent cell. SOX2 is amplified in various types of epithelial cancers and its high its expression correlates with poor prognosis and …
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MEF2-regulated Gtl2-Dio3 noncoding RNAs in cardiac muscle and disease
… showed that miR-410 and miR-495 stimulate cell cycle re-entry and proliferation of terminally differentiated NRVMs. Subsequent target prediction analyses revealed a number of candidate target genes known to function in the cell cycle and/or in cardiac muscle. One of these was Cited2, a …
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MicroRNA-mediated Attenuation of Inflammation in NZB/W Lupus Mice
… expression, may contribute to aberrant immune cell function in SLE. miRNAs are small, noncoding RNAs that bind to the 3’ untranslated region of target mRNAs resulting in post-transcriptional gene modulation. IL-6, an inflammatory cytokine overproduced by mesangial cells in SLE, contains a …
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Einfluss einer ABCC6-Defizienz auf die Remodellierung der extrazellulären Matrix in in vitro und ex vivo Gewebemodellen
… in lipid homeostasis, remodeling of the extracellular matrix (ECM), ectopic calcification, and inflammation. Symptomatically, these are reflected peripherally in the dermis, retina, and vascular walls. Mutations in the ATP binding cassette subfamily C member 6 (ABCC6) gene are the cause of …
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Epigallocatechin-3-gallate and tolfenamic acid induces apoptosis and growth inhibition in head and neck cancer : Involvement of NSAID activated gene-1
… a high mortality rate, head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in men. The 5-year overall survival rate for patients with advanced HNSCC is around 30%, which is essentially unchanged from the rate recorded two decades ago in spite of various treatment …
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THE ROLE OF P2Y RECEPTORS IN HUMAN VASCULAR SMOOTH MUSCLE
… or inappropriate vascular smooth muscle (VSM) cell proliferation is a major contributor to proliferative disorders such as atherosclerosis and restenosis following angioplasty. Treatment is by bypass grafting using the internal mammary artery (IMA) or saphenous vein (SV). IMA conduits show …
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THE ROLE OF NOTCH SIGNALING IN THE DIFFERENTIAL ABILITY OF SUPPORTING CELL SUBTYPES TO SPONTANEOUSLY REGENERATE HAIR CELLS IN THE NEONATAL MOUSE COCHLEA
… loss in hearing is the loss of the sensory hair cells (HCs) within the cochlea. Also in the mammalian cochlea, six major groups of supporting cell (SC) subtypes reside in close proximity to HCs and may have the potential to regenerate HCs after damage. These subtypes include cells of the greater …
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Delineating mechanisms which underlie differential cell fates induced by p53 activation and HDAC inhibition in colorectal cancer
… for inducing p53 stabilisation within the cell. Strategies aimed at reactivating latent wild-type p53 in such tumours therefore hold enormous clinical potential. This led to the development of small molecule inhibitors of the E3 ubiquitin ligase, MDM2, which normally targets p53 for …
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Investigating the functional significance of the upregulation of Cyclin D2 and p21 following Apc loss in vivo
… is noteworthy as c-Myc is implicated in stem cell survival, proliferation, apoptosis and tumourigenesis. Previous studies have shown c-Myc dependency for both apoptosis and proliferation following activation of the Wnt pathway, however little is known about the role c-Myc plays in inducing …
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The effects of adult exposure to genistein on female reproductive outcomes
… Crosstalk between the theca and granulosa cells of the antral follicle is responsible for the production of sex steroid hormones that are necessary for fertility and overall female health. Enzymes in the theca cells metabolize cholesterol to estradiol precursor hormones such as progesterone …