Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 251 for “"cell cycle arrest"”.
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Fas-induced apoptosis: dephosphorylation and cleavage of the retinoblastoma protein leads to cell cycle arrest
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The candidate tumour suppressor, XIAP associated factor 1 (XAF1), directly inhibits XIAP activity and induces G1 phase cell cycle arrest
… Furthermore, overexpression of XAF1A in HEL299 cells triggered a G1 cell cycle arrest. This G1 arrest coincides with an increase in p21, but not p53. The ability of XAF1 to block XIAP function and induce cell cycle arrest suggests a role for XAF1 in the control of both apoptosis and cell growth. …
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Strategies for the Selective Treatment of Cancer, Including the Identification and Mechanism of Action of Compounds That Induce G1 Cell Cycle Arrest
… agents and the identification of novel cellular targets are imperative for the successful treatment of cancer, as well as to gain a more complete understanding of how cells work. Such efforts will bring us closer to the goal of personalizing medicine by targeting specific weaknesses in …
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Small Molecule Modulation of the Cell Cycle: Discovery of Anticancer Compounds That Induce G1- and M-Phase Cell Cycle Arrest and Characterization of Their Modes of Action
… was pursued for its ability to induce G1 cell cycle arrest and apoptosis in melanoma cells, a cell type notoriously resistant to several common classes of chemotherapeutics. It was determined that TPMAs act via disrution of normal endoplasmic reticulum function, inducing apoptosis through …
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Sulforaphane Inhibits Mammary Cancer Cell Mitotic Progression and Tubulin Polymerization
… tumors in rodents, and more recently to induce cell cycle arrest and apoptosis in colon cancer cells. Here, we provide evidence that SUL also acts as a breast cancer antiproliferative agent. The BALB/c mouse mammary carcinoma cell line F3II was treated with SUL at concentrations up to 15 muM and …
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Investigation of the p53-dependent apoptosis versus arrest decision through analysis of Prep gene regulation
… to check the growth of abnormal or damaged cells through initiation of the cell cycle arrest and apoptosis pathways. p53 itself is mutated in roughly half of all human tumors and is likely to be inactivated through mutations in other components of the stress response pathway in the remaining …
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Anti-proliferative effect of methyl gallate isolated from mangifera pajang kosterman in selected cancer cell lines
… aromatic ester, methyl gallate which induce the cell cycle arrest and killing mechanism via apoptosis in selected cancer cell line. Chromatography methods were used in this study to isolate methyl gallate (C8H8O5) from methanol crude extract. Identification of the isolated compound was done by …
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The Immediate Early Response of Proliferating Myoblasts to One Bout of Electrical Stimulation
… across the lifespan. The activation of satellite cells, followed by their proliferation and subsequent differentiation is important in this maintenance. Cell cycle arrest must precede differentiation, and preservation of the molecular networks involved within the regenerative process are …
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The chronic response to centrosome loss-induced cell cycle exit
… as a microtubule organising centre in eukaryotic cells, to allow normal progress through the cell cycle. While centrosome amplification in the absence of p53 is a well-established feature of cancers, more recently centrosome loss was also detected in tumour tissues. The development of a small …
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Electrical stimulation effects on cell cycle and autophagy markers in MCF7 and MDA-MB-468 breast cancer cells
… pulse stimulation (EPS) on breast cancer cells. This is based on previous work on myoblasts, cancerous rhabdomyosarcoma cells, and MCF7 breast cancer cells. EPS of MCF7 and MDA-MB-468 breast cancer cells revealed alterations in cellular signaling that suggest cell cycle arrest by …
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Modulation of the Magnetic Properties of Aqueous Metal Ions and the Bioelectrodynamic Effects on Cancerous and Noncancerous Cells
… the effects on biochemical processing at the cellular level. The Cellular Energy Transfer Science (CETS) system modulates the magnetic behavior of aqueous metal ions by applying direct current (DC) with a Lorenz force to a hypotonic saline solution. This treated solution was then used to make …
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Negative regulation of gene expression by the tumor suppressor p53
… of genes whose protein products serve to promote cell survival or cell cycle progression, thereby ensuring efficient execution of p53-dependent apoptosis, cell-cycle arrest or senescence. Furthermore, p53-mediated repression has also been shown to participate in pathways that regulate diverse …
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Altered DNA Repair, Antioxidant and Cellular Proliferation Status as Determinants of Susceptibility to Methylmercury Toxicity in Vitro
… (Fpg)-expressing human embryonic kidney (HEK) cells; reciprocal in vitro cellular models with deficient and enhanced ability to repair oxidatively damaged DNA respectively. When spontaneously-immortalized wild-type and Ogg1-/- MEFs were exposed to environmentally relevant, low micromolar …
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Induction And Regulation Of Autophagy By Novel Prenylation Inhibitors In Sts-26t Malignant Peripheral Nerve Sheath Tumor (mpnst) Cells
… transferase (GGTase) enzymes in many cellular and animal models of cancer. Some of these have also been evaluated in clinical trials with limited success. Multiple mechanisms of action have been elucidated for such compounds, including cell cycle arrest, proteasome inhibition, …
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Increased Geranylgeranylated K-Ras Contributes to Antineoplastic Effects of Farnesyltransferase Inhibitors.
… maintain low level activity to achieve optimal cell growth. In cells with endogenously low levels of active Ras, increasing Ras signaling through the ERK and p38 MAPK pathways can cause growth arrest or cell death. Ras requires prenylation – the addition of a 15-carbon (farnesyl) or 20-carbon …
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Quantitative measurement and modeling of the DNA damage signaling network : DNA double-strand breaks
… of chemotherapy-induced cytotoxicity in tumors. Cells that experience DNA damage can initiate a DNA damage-mediated cell-cycle arrest, attempt to repair the damage and, if successful, resume the cell-cycle (arrest/repair/resume). Cells can also initiate an active cell-death program known as …
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Nuclear receptor co-repressor actions in bladder cancer
… NRs and co-repressors in four bladder cancer cell lines. Nuclear co-repressor 1 (NCoR1) is over-expressed in RT-112 (1.6 fold) and EJ-28 cells (2.6 fold). This correlates with reduced sensitivity to NR ligands in EJ-28 cells. Stable over-expression of NCoR1 in sensitive RT-4 cells (lowest …
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In-vivo investigation of resveratrol as a preventive for radiation-induced acute myeloid leukemia
… those involved with induction of apoptosis and cell cycle arrest in a concentration dependent fashion. This study was designed to investigate resveratrol's ability to reduce radiation-induced chromosome aberrations and PU.1 gene loss in mouse bone marrow cells. Loss of 1 PU.1 gene and missense …
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STAUROSPORINE-INDUCED APOPTOSIS/PROGRAMMED CELL DEATH
Apoptosis is the mechanism by which cells are programmed to die under a wide range of physiological and developmental stimuli. Three phases of the apoptosis process, (a) induction phase, (b) commitment phase and (c) degradation phase, have been described in interphase cells only. This study …
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