Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"cell composition"”.
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Route of Nutrient Administration Alters Intestinal Immune Cell Composition in Neonatal Piglets
… function. The impact of TPN on intestinal immune cell composition in neonates has been poorly characterized. Therefore, the central objective of this doctoral research was to determine the effects of TPN on intestinal immune cell composition in the developing intestine. The neonatal piglet was …
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Determination of Thymic Epithelial Cell Composition and Proliferation During The Perinatal to Adult Transition
<p>T-cells develop in the thymus based on signaling from multiple stromal cell types, particularly thymic epithelial cells (TECs). The thymus develops rapidly during the perinatal time period (birth – 10 days in mice) before reaching a period of homeostasis (10 days – 6 weeks). The mechanisms that …
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Characterizing Changes in T Cell Composition and Function Within Prostate Tumors Following Androgen Ablation and Non-invasive Imaging of Anti-Tumor Immune Responses
… The goal of cancer immunotherapy is to use the cells of the immune system to eradicate tumors. This is an especially attractive option for the treatment of androgen independent prostate cancer because as an immunogenic, non-vital organ, collateral prostate tissue damage is not life threatening. …
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Regulation of Ammonia Assimilating Enzymes in the Ruminal Bacteria Selenomonas Ruminantium and Succinivibrio Dextrinosolvens
… dilution rate and growth-limiting nutrients on cell physiology, efficiency of growth and ammonia assimilating enzymes. Culture viability was decreased at low dilution rates for both growth-limiting conditions, but the decrease in viability was more severe in glucose-limited cultures. Cell …
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Cellular Kaleidoscope: Unveiling Tissue Microenvironment in Health and Disease
Cells are the fundamental units of life. In multicellular organisms, cells are organised into tissues, where groups of similar cells work together to perform specific tasks. Understanding how tissues and organs function requires insight into the dynamics between different cell populations. Changes …
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Genomic profiling of response to $\textit{in vivo}$ immune perturbations
… related to the inflammatory response, the cell cycle, CD4+ T cells, and plasma cells to be associated with vaccine-induced antibody response. In Chapter 3, I map response expression quantitative trait loci (reQTLs) in the HIRD cohort to investigate regulation of transcriptomic response by …
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The Administration of P2Y12 Antagonist (P113) Attenuates Airway hyperresponsiveness and Airway Inflammation in an Ovalbumin (OVA) Specific Allergic Asthma Model
… OVA challenge. Airway responsiveness (AHR), cell composition and cytokine levels in bronchoalveolar lavage (BAL) fluid were evaluated.Human eosinophil EOL-1 cells were treated with LTE4 with or without pre-treatment of P113. Intracellular expression of ECP was evaluated by Western blot, …
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Functional Analysis of Daxx In Tumorigenesis of Pancreatic Neuroendocrine Tumors and Embryonic Development
… retroviruses and for maintaining proper immune cell composition. Combined, this study extends our understanding in Daxx functions.</p>
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Generative modeling of the tumor microenvironment : deconvolution, completion, and integration
… each observation mixes signals from multiple cells; completion, where important channels or sequences are missing; and integration, where complementary modalities are measured on adjacent sections without direct correspondence. Existing methods typically address these settings separately and …
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Immune system involvement in metal hip implant failure
… implant failure association. Determined the composition and frequency of immune cells and inflammatory markers in Norfolk cohort. And tested the metal particle impact on immune cells. These experimental approaches were utilised to elucidate whether the metal implant failure is a result of …
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THE PHYSIOLOGICAL RESPONSE OF PICOPHYTOPLANKTON TO LIGHT, TEMPERATURE AND NUTRIENTS, INCLUDING CLIMATE CHANGE MODEL SIMULATIONS
… the Q10 value is even higher (4.9). The cell composition in both groups deviates significantly from the Redfield ratio under nutrient saturated conditions with a lower phosphorus demand in picoprokaryotes. Under nutrient limitation nitrogen: carbon is reduced by 15 − 42%, and phosphorus: …
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Human leptomeninges; inflammatory roles in motor neuron disease, and their potential in gene therapy
… of the model was established by assessing cell composition and tissue health. Cell markers identified four specific cell populations in the intact explants expressing IBA1 and/or P2RY12, or PDGFRβ and/or lectin. Specific culture paradigms were used to explore culture-driven effects on the …
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Hydrothermal liquefaction of microalgae: Influence of varying cell compositions on biocrude yield and quality
… relationships between different biochemical compositions of a single species and HTL which contribute to the understanding of the overall system remain unexplored. This study examines the influence of varying microalgae cell composition on HTL biocrude yield and chemical composition. …
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Behavioral and genetic characteristics of intestinal cell lineages in health and disease
… over and renewed by the proliferative stem cells located at the bottom of the crypt. While this system is crucial for nutrient absorption, any derangements in the proliferative cells can quickly lead to cancer. In this thesis, we sought to better understand the behavioral and genetic …
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Precision Medicine Approach to Improving Reconstructive Surgery Outcomes for Breast Cancer Survivors
… demonstrated differences in structure and cell composition between different capsule severities. Of particular note, a new region was described which could serve as the communication interface between innate immune cells and fibroblasts. RNA-seq analysis identified 1029 significantly …
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White Adipose Tissue Remodeling by Intermittent Fasting
… dysfunction is unclear. Furthermore, the cellular target of IF and its underlying mechanisms remain to be elucidated.First, to understand the heterogeneity of WAT depots, we performed CyTOF analysis on stromal and immune cells of inguinal WAT (IWAT) and perigonadal WAT (PWAT) under normal …
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Genomic architecture of the aging hematopoietic system
… process continuously replenishing populations of cells, including those with immune functions, that circulate in peripheral blood. Aging is associated with changes in hematopoiesis, resulting in altered composition and reduced function of immune cells, increasing risk of disease in the elderly. …
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FROM A PLACODE PROGENITOR PLATFORM TO A TRIGEMINAL GANGLION ORGANOID: MODELLING SENSORY DEVELOPMENT AND FUNCTION IN VITRO
… models of the ganglion. Human pluripotent stem cells can be differentiated towards three-dimensional organoids mirroring tissue development, morphology and function, but organoids of the TG are yet to be developed. Here, we aim at generating the first TG organoid (TGO) and at characterising its …
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ACUTE ISCHEMIC STROKE: CANCER-RELATED STROKE AND MULTIMODAL ANALYSIS OF THROMBI.
… omics data. Histology assessed fibrin/red blood cell content and immune-cell composition. Proteomic and transcriptomic analyses explored convergent pathways and cross-platform signatures. Results Among 464 AIS patients with AC from ASTRAL, anticoagulation at discharge did not reduce recurrent AIS …
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